Porokeratosis - Porokeratoza
☆ În rezultatele Stiftung Warentest din Germania din 2022, satisfacția consumatorilor față de ModelDerm a fost doar puțin mai mică decât în cazul consultațiilor plătite de telemedicină.
Marginile proeminente dure sunt caracteristice.
References
Porokeratosis este o afecțiune rară a pielii, caracterizată prin probleme de keratinizare, care au ca rezultat pete în relief, în formă de inel sau umflături aspre pe piele. Caracteristica sa definitorie la microscop este prezența lamelei cornoide, un aranjament specific de celule în stratul superior al pielii. Porokeratosis vine în diferite forme, cum ar fi disseminated superficial actinic porokeratosis, classical porokeratosis of Mibelli, porokeratosis palmaris plantaris et disseminatum, and linear porokeratosis. Este important să rețineți că porokeratosis se poate transforma în cancer de piele. Cel mai bun mod de a diagnostica porokeratosis este printr-o biopsie a marginii înălțate, deși în prezent nu există un protocol standard de tratament.
Porokeratosis is an uncommon dermatologic disorder. It is a disorder of keratinization that presents with keratotic papules or annular plaques with an elevated border. It has a distinct histologic hallmark of cornoid lamella, which is a column of tightly fitted parakeratotic cells in the upper epidermis. There are multiple clinical variants of porokeratosis, including disseminated superficial actinic porokeratosis, classical porokeratosis of Mibelli, porokeratosis palmaris plantaris et disseminatum, and linear porokeratosis. Porokeratosis is a precancerous lesion that can undergo malignant transformation. Evaluation of porokeratosis is best with a biopsy of the elevated border. There are no standard guidelines for treatment.
Porokeratosis is an uncommon dermatologic disorder. It is a disorder of keratinization that presents with keratotic papules or annular plaques with an elevated border. It has a distinct histologic hallmark of cornoid lamella, which is a column of tightly fitted parakeratotic cells in the upper epidermis. There are multiple clinical variants of porokeratosis, including disseminated superficial actinic porokeratosis, classical porokeratosis of Mibelli, porokeratosis palmaris plantaris et disseminatum, and linear porokeratosis. Porokeratosis is a precancerous lesion that can undergo malignant transformation. Evaluation of porokeratosis is best with a biopsy of the elevated border. There are no standard guidelines for treatment.
Disseminated superficial actinic porokeratosis (DSAP) este o boală a keratinizării dezordonate. Este unul dintre cele șase tipuri de porokeratoză și afectează de obicei zone mai mari în comparație cu celelalte (linear, Mibelli's, punctate, palmoplantar disseminated, and superficial porokeratosis) . Tipul eruptiv de porokeratoză se leagă adesea de cancer, imunitate slăbită sau inflamație. Factorii de risc implică genetica, suprimarea imunității și expunerea la soare. DSAP începe ca umflături roz sau maro cu margini înălțate în zonele expuse la soare, provocând uneori ușoare mâncărimi. Tratamentele variază și pot include creme topice, terapie cu lumină sau medicamente precum 5-fluorouracil sau retinoizi. Aceste leziuni sunt considerate precanceroase, cu o șansă de 7. 5 - 10 % de a se transforma în carcinom spinocelular sau bazocelular.
Disseminated superficial actinic porokeratosis (DSAP) is a disease of disordered keratinization. Disseminated superficial actinic porokeratosis is one of six variants of porokeratosis. It has more extensive involvement than most other variants. These other variants include linear porokeratosis, porokeratosis of Mibelli, punctate porokeratosis, porokeratosis palmaris et plantaris disseminata, and disseminated superficial porokeratosis. The eruptive form of porokeratosis is associated with malignancy, immunosuppression, and a proinflammatory state. Risk factors for porokeratosis include genetics, immunosuppression, and ultraviolet light. The lesions in disseminated superficial actinic porokeratosis start as pink to brown papules and macules with a raised border in sun-exposed areas that can be asymptomatic or slightly pruritic. There are many options for the treatment of disseminated superficial actinic porokeratosis, including topical diclofenac, photodynamic therapy (PDT), 5-fluorouracil (5-FU), imiquimod, vitamin D analogs, retinoids, and lasers. These lesions are considered precancerous. There is a 7.5 to 10% risk of malignant transformation to squamous cell carcinoma or basal cell carcinoma.
Disseminated superficial actinic porokeratosis (DSAP) is a disease of disordered keratinization. Disseminated superficial actinic porokeratosis is one of six variants of porokeratosis. It has more extensive involvement than most other variants. These other variants include linear porokeratosis, porokeratosis of Mibelli, punctate porokeratosis, porokeratosis palmaris et plantaris disseminata, and disseminated superficial porokeratosis. The eruptive form of porokeratosis is associated with malignancy, immunosuppression, and a proinflammatory state. Risk factors for porokeratosis include genetics, immunosuppression, and ultraviolet light. The lesions in disseminated superficial actinic porokeratosis start as pink to brown papules and macules with a raised border in sun-exposed areas that can be asymptomatic or slightly pruritic. There are many options for the treatment of disseminated superficial actinic porokeratosis, including topical diclofenac, photodynamic therapy (PDT), 5-fluorouracil (5-FU), imiquimod, vitamin D analogs, retinoids, and lasers. These lesions are considered precancerous. There is a 7.5 to 10% risk of malignant transformation to squamous cell carcinoma or basal cell carcinoma.
Un bărbat de 52 de ani, anterior sănătos, a intrat cu un plasture plat, în formă de inel, la capătul celui de-al patrulea deget de la picior, care se afla acolo de 2 ani fără să provoace niciun simptom. A început ca un cucui mic și dur și a crescut în exterior în timp. În ciuda încercării diferitelor tratamente, cum ar fi crioterapia, creme, antifungice și antibiotice, plasturele nu s-a îmbunătățit. Examinând-o îndeaproape cu o dermocopsie a arătat un centru uscat, roșu, cu o margine groasă și aspră. O bucată minusculă de piele luată de la marginea plasturelui a arătat o creștere anormală a celulelor în stratul exterior al pielii, confirmând un diagnostic de porokeratosis of Mibelli.
A 52-year-old man with no past medical history presented with an asymptomatic annular atrophic patch on the distal portion of the fourth toe of 2 years’ duration. The lesion began as a small keratotic papule that gradually enlarged centrifugally. He had received multiple treatments including cryotherapy, topical corticosteroids, antifungals, and antibiotics without improvement. Dermoscopic examination revealed a scaly atrophic erythematous central area with a sharply demarcated peripheral hyperkeratotic structure. A skin biopsy of the edge of the lesion revealed a cornoid lamella with a column of parakeratotic cells extending from an invagination of the epidermis with absence of granular layer. The clinicopathologic correlation was consistent with porokeratosis of Mibelli.
A 52-year-old man with no past medical history presented with an asymptomatic annular atrophic patch on the distal portion of the fourth toe of 2 years’ duration. The lesion began as a small keratotic papule that gradually enlarged centrifugally. He had received multiple treatments including cryotherapy, topical corticosteroids, antifungals, and antibiotics without improvement. Dermoscopic examination revealed a scaly atrophic erythematous central area with a sharply demarcated peripheral hyperkeratotic structure. A skin biopsy of the edge of the lesion revealed a cornoid lamella with a column of parakeratotic cells extending from an invagination of the epidermis with absence of granular layer. The clinicopathologic correlation was consistent with porokeratosis of Mibelli.
Adesea se efectuează o biopsie, deoarece poate arăta asemănător cu keratoza actinică sau cu carcinomul cu celule scuamoase.