وڌيڪ ڄاڻ ― سنڌي

Cutaneous angiofibromas جسم جي مختلف حصن ۾ ظاهر ٿي سگھي ٿو. منهن تي، اهي اڪثر ڪري سڃاتل آهن fibrous papules يا adenoma sebaceum؛ عضون تي، انهن کي سڏيو ويندو آهي pearly penile papules ؛ نيل جي هيٺان، انهن کي periungual angiofibromas يا Koenen tumors سڏيو ويندو آهي؛ ۽ وات ۾، انهن کي زباني فائبروماس سڏيو ويندو آهي. Facial angiofibromas tuberous sclerosis (TS) جي هڪ نمايان خصوصيت آهي، هڪ موروثي خرابي جيڪا چمڙي، گردن، دل، دماغ ۽ ڦڦڙن کي متاثر ڪري ٿي. اهي عام طور تي TS سان ماڻهن ۾ ننڍپڻ يا ابتدائي بالغ ٿيڻ دوران منهن تي ترقي ڪن ٿا. ٽي يا وڌيڪ منهن واري اينجيوفائبروماس هجڻ يا ٻه يا وڌيڪ پيرونگول اينجيوفائبروماس کي TS جي تشخيص ۾ اهم سمجهيو ويندو آهي. اضافي طور تي، ڪيترن ئي منهن جي angiofibromas حالتن ۾ موجود ٿي سگھي ٿي (multiple endocrine neoplasia type 1 (MEN-1) ۽ Birt-Hogg-Dubé syndrome) . Pearly penile papules عضون جي ڪورونل مارجن ۽ سلڪس سان مليا آهن. اهي لڳاتار، بي درد ٽڪنڊا آهن، جيڪي عام طور تي اڻ طويل مردن ۾ ڏٺا ويندا آهن.
Cutaneous angiofibromas can be located on different areas of the body including the face where they are commonly called fibrous papules or adenoma sebaceum on the penis where they are called pearly penile papules, underneath the nail where they are called periungual angiofibromas or Koenen tumors, and in the mouth where they are called oral fibromas. Facial angiofibromas are considered one of the most obvious clinical presentations of tuberous sclerosis (TS), an autosomal dominant hamartomatous disorder that affects the skin, kidneys, heart, brain, and lungs. With TS, angiofibromas typically arise on the face in childhood and early adulthood. Both facial angiofibromas (greater than or equal to 3 needed) and periungual angiofibroma (greater than or equal to 2 needed) are 2 of the major criteria for TS. Multiple facial angiofibromas are also found in multiple endocrine neoplasia type 1 (MEN-1) and Birt-Hogg-Dube syndrome. Pearly penile papules are chronic, asymptomatic, papules found on the coronal margin and sulcus of the penis. They are more common in uncircumcised men.