Livedoid vasculitis
Livedoid vasculitis ھڪ دائمي چمڙيءَ جي بيماري آهي، جيڪا اڪثر نوجوانن کان وچولي عمر جي عورتن ۾ ڏسڻ ۾ اچي ٿي. ان جي خاصيتن کي بيان ڪرڻ لاءِ مخفف "Painful purpuric ulcers with the reticular pattern of the Lower extremities" (PURPLE) استعمال ڪيو ويو آهي. اها بيماري ڪيترن ئي ٻين بيمارين سان جڙيل آهي، جن ۾ دائمي وينس هائپر ٽائونشن ۽ ويريڪوسيٽس شامل آهن.
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2022 ۾ جرمني مان Stiftung Warentest نتيجن، ModelDerm سان صارفين جي اطمينان صرف ادا ڪيل ٽيلي ميڊيسن مشوري جي ڀيٽ ۾ ٿورو گهٽ هئي.
2022 ۾ جرمني مان Stiftung Warentest نتيجن، ModelDerm سان صارفين جي اطمينان صرف ادا ڪيل ٽيلي ميڊيسن مشوري جي ڀيٽ ۾ ٿورو گهٽ هئي.
اهو درد سان گڏ ٿي سگهي ٿو.
relevance score : -100.0%
ReferencesLivedoid vasculopathy هڪ نادر چمڙي جي حالت آهي، جنهن جي خاصيت دردناڪ السر آهي، جيڪا هيٺين پيرن تي بار بار واپس اچي ٿي.
Livedoid vasculopathy (LV) is a rare thrombotic vasculopathy of the dermis characterized by painful, relapsing ulcers over the lower extremities. Diagnosis is challenging due to the overlap in clinical appearance and nomenclature with other skin disorders. Treatment selection is complicated by poor understanding of the pathogenesis of LV and lack of robust clinical trials evaluating therapy efficacy. The terminology and pathophysiology of LV are reviewed here, along with its epidemiology, clinical and histologic features, and treatment options. A diagnostic pathway is suggested to guide providers in evaluating for comorbidities, referring to appropriate specialists, and choosing from the available classes of therapy.
Livedoid vasculopathy (LV) is a rare thrombotic vasculopathy of the dermis characterized by painful, relapsing ulcers over the lower extremities. Diagnosis is challenging due to the overlap in clinical appearance and nomenclature with other skin disorders. Treatment selection is complicated by poor understanding of the pathogenesis of LV and lack of robust clinical trials evaluating therapy efficacy. The terminology and pathophysiology of LV are reviewed here, along with its epidemiology, clinical and histologic features, and treatment options. A diagnostic pathway is suggested to guide providers in evaluating for comorbidities, referring to appropriate specialists, and choosing from the available classes of therapy.
Livedoid vasculopathy چمڙي جي هڪ نادر حالت آهي جيڪا هيٺين پيرن تي بار بار السر جو سبب بڻجندي آهي؛ ان جي پوئتي پيلا داغ ڇڏيندي آهي جن کي Atrophie Blanche سڏيو ويندو آهي. جڏهن ته صحيح سبب اڃا تائين واضح نه آهي، پر يقين آهي ته رت جي ٺهڻ ۾ اضافو (hypercoagulability) بنيادي عنصر آهي، ۽ سوزش صرف ثانوي ڪردار ادا ڪري ٿي. ڪلٽنگ ۾ شامل عوامل هي آهن: پروٽين C ۽ S جي گهٽتائي، factor V Leiden جهڙيون جيني تبديليون، antithrombin III جي گهٽتائي، prothrombin جين جي تبديليون، ۽ هوموسسٽين جي بلند سطحن. بايوپسيز ۾، حالت رت جي ڪلٽن جي موجودگي، ويسلن جي ڀتين جي ٿلهي، ۽ زخم جي تشڪيل ڏيکاري ٿي. علاج ۾ گھڻائي وارو طريقو شامل آهي جيڪو رت جي ڪلٽن کي روڪڻ تي ڌيان ڏئي ٿو؛ مثال طور اينٽي پليٽليٽ دوائون، رت پتلو ڪندڙ دوائون، ۽ فائبرنولائيٽ علاج. هن چمڙي جي حالت لاءِ مختلف دوائون استعمال ڪري سگهجن ٿيون، جهڙوڪ colchicine and hydroxychloroquine, vasodilators, immunosuppressants.
Livedoid vasculopathy is a rare skin condition that causes recurring ulcers on the lower legs, leaving behind pale scars known as atrophie blanche. While the exact cause is still unclear, it's believed that increased blood clotting (hypercoagulability) is the main factor, with inflammation playing a secondary role. Factors contributing to clotting include as follows - deficiencies in proteins C and S, genetic mutations like factor V Leiden, antithrombin III deficiency, prothrombin gene mutations, high levels of homocysteine. In biopsies, the condition shows blood clots inside vessels, thickening of vessel walls, and scarring. Treatment involves a multi-pronged approach focusing on preventing blood clots with medications like anti-platelet drugs, blood thinners, and fibrinolytic therapy. Various drugs can be used for this skin condition - colchicine and hydroxychloroquine, vasodilators, immunosuppressants.
Livedoid vasculopathy is a rare skin condition that causes recurring ulcers on the lower legs, leaving behind pale scars known as atrophie blanche. While the exact cause is still unclear, it's believed that increased blood clotting (hypercoagulability) is the main factor, with inflammation playing a secondary role. Factors contributing to clotting include as follows - deficiencies in proteins C and S, genetic mutations like factor V Leiden, antithrombin III deficiency, prothrombin gene mutations, high levels of homocysteine. In biopsies, the condition shows blood clots inside vessels, thickening of vessel walls, and scarring. Treatment involves a multi-pronged approach focusing on preventing blood clots with medications like anti-platelet drugs, blood thinners, and fibrinolytic therapy. Various drugs can be used for this skin condition - colchicine and hydroxychloroquine, vasodilators, immunosuppressants.
Livedoid vasculopathy هڪ نادر حالت آهي، جتي زخم ٻنهي پيرن تي ٿيندا آهن. ننڍڙن رت جي نالن ۾ رت جي ڪلٽن جي ٺهڻ سبب سمجهيو ويندو آهي؛ ڪلٽنگ وڌڻ ۽ رت جي ڦاٽن جي گھٽتائي سان ويسلن جي استر کي نقصان پهچندو آهي. اهو عورتن ۾ وڌيڪ عام آهي، خاص طور تي 15 ۽ 50 سالن جي وچ ۾. تماڪ ڇڏڻ، زخمن جو خيال رکڻ، ۽ رت کي پتلي ڪندڙ ۽ اينٽي پليٽليٽ دوائن جو استعمال اثرائتو ثابت ٿيو آهي.
Livedoid vasculopathy is a rare vasculopathy that is typically characterized by bilateral lower limb lesions. Increased thrombotic activity and decreased fibrinolytic activity along with endothelial damage are believed to be the cause of thrombus formation in the capillary vasculature. It is 3 times more common in females than in males, especially in patients between the ages of 15 to 50 years. There is no definite first-line treatment, but general measures like smoking cessation, wound care, and pharmacological measures like anticoagulants and antiplatelets have shown good results.
Livedoid vasculopathy is a rare vasculopathy that is typically characterized by bilateral lower limb lesions. Increased thrombotic activity and decreased fibrinolytic activity along with endothelial damage are believed to be the cause of thrombus formation in the capillary vasculature. It is 3 times more common in females than in males, especially in patients between the ages of 15 to 50 years. There is no definite first-line treatment, but general measures like smoking cessation, wound care, and pharmacological measures like anticoagulants and antiplatelets have shown good results.
