Porokeratosis
☆ 2022 ۾ جرمني مان Stiftung Warentest نتيجن، ModelDerm سان صارفين جي اطمينان صرف ادا ڪيل ٽيلي ميڊيسن مشوري جي ڀيٽ ۾ ٿورو گهٽ هئي.
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References
Porokeratosis چمڙي جي هڪ ناياب حالت آهي جنهن ۾ ڪيريٽائنائيزيشن جي مسئلن جي نشاندهي ڪئي وئي آهي، جنهن جي نتيجي ۾ چمڙيءَ تي اڀريل، انگوزي جي شڪل جا پيچ يا ٿلها داغ. خوردبيني جي هيٺان ان جي وضاحت واري خصوصيت ڪورنائڊ لاملا جي موجودگي آهي، چمڙي جي مٿين پرت ۾ سيلز جو هڪ خاص ترتيب. Porokeratosis مختلف شڪلن ۾ اچي ٿو (disseminated superficial actinic porokeratosis, classical porokeratosis of Mibelli, porokeratosis palmaris plantaris et disseminatum, linear porokeratosis) . اهو نوٽ ڪرڻ ضروري آهي ته porokeratosis ممڪن طور تي چمڙي جي ڪينسر ۾ ترقي ڪري سگهي ٿي. تشخيص ڪرڻ جو بهترين طريقو porokeratosis بلند ٿيل بارڊر جي بايوپسي ذريعي آهي، جيتوڻيڪ في الحال ڪوبه معياري علاج پروٽوڪول ناهي.
Porokeratosis is an uncommon dermatologic disorder. It is a disorder of keratinization that presents with keratotic papules or annular plaques with an elevated border. It has a distinct histologic hallmark of cornoid lamella, which is a column of tightly fitted parakeratotic cells in the upper epidermis. There are multiple clinical variants of porokeratosis, including disseminated superficial actinic porokeratosis, classical porokeratosis of Mibelli, porokeratosis palmaris plantaris et disseminatum, and linear porokeratosis. Porokeratosis is a precancerous lesion that can undergo malignant transformation. Evaluation of porokeratosis is best with a biopsy of the elevated border. There are no standard guidelines for treatment.
Porokeratosis is an uncommon dermatologic disorder. It is a disorder of keratinization that presents with keratotic papules or annular plaques with an elevated border. It has a distinct histologic hallmark of cornoid lamella, which is a column of tightly fitted parakeratotic cells in the upper epidermis. There are multiple clinical variants of porokeratosis, including disseminated superficial actinic porokeratosis, classical porokeratosis of Mibelli, porokeratosis palmaris plantaris et disseminatum, and linear porokeratosis. Porokeratosis is a precancerous lesion that can undergo malignant transformation. Evaluation of porokeratosis is best with a biopsy of the elevated border. There are no standard guidelines for treatment.
Disseminated superficial actinic porokeratosis (DSAP) بيڪار keratinization جي بيماري آهي. اهو ڇهن قسمن مان هڪ آهي porokeratosis، ۽ اهو عام طور تي ٻين جي مقابلي ۾ وڏن علائقن کي متاثر ڪري ٿو (linear, Mibelli's, punctate, palmoplantar disseminated, superficial porokeratosis) . ٻرندڙ قسم جو پوروڪريٽوسس اڪثر ڪري ڪينسر، ڪمزور قوت مدافعت، يا سوزش سان ڳنڍيل آهي. خطري جا عنصر شامل آهن جينياتي، مدافعتي دٻاء، ۽ سج جي نمائش. DSAP شروع ٿئي ٿو گلابي يا ڳاڙهي رنگ جي ٿڌن سان اڀريل ڪنارن سان سج جي روشني وارن علائقن ۾، ڪڏهن ڪڏهن ٿوري خارش جو سبب بڻجندي آهي. علاج مختلف هوندا آهن ۽ انهن ۾ شامل ٿي سگھي ٿو بنيادي ڪريم، هلڪو علاج، يا دوائون جهڙوڪ 5-fluorouracil يا retinoids. انهن زخمن کي اڳڪٿي ڪندڙ سمجهيو ويندو آهي، جنهن ۾ اسڪواومس سيل يا بيسل سيل ڪارڪينوما ۾ تبديل ٿيڻ جو 7. 5 - 10 % امڪان هوندو آهي.
Disseminated superficial actinic porokeratosis (DSAP) is a disease of disordered keratinization. Disseminated superficial actinic porokeratosis is one of six variants of porokeratosis. It has more extensive involvement than most other variants. These other variants include linear porokeratosis, porokeratosis of Mibelli, punctate porokeratosis, porokeratosis palmaris et plantaris disseminata, and disseminated superficial porokeratosis. The eruptive form of porokeratosis is associated with malignancy, immunosuppression, and a proinflammatory state. Risk factors for porokeratosis include genetics, immunosuppression, and ultraviolet light. The lesions in disseminated superficial actinic porokeratosis start as pink to brown papules and macules with a raised border in sun-exposed areas that can be asymptomatic or slightly pruritic. There are many options for the treatment of disseminated superficial actinic porokeratosis, including topical diclofenac, photodynamic therapy (PDT), 5-fluorouracil (5-FU), imiquimod, vitamin D analogs, retinoids, and lasers. These lesions are considered precancerous. There is a 7.5 to 10% risk of malignant transformation to squamous cell carcinoma or basal cell carcinoma.
Disseminated superficial actinic porokeratosis (DSAP) is a disease of disordered keratinization. Disseminated superficial actinic porokeratosis is one of six variants of porokeratosis. It has more extensive involvement than most other variants. These other variants include linear porokeratosis, porokeratosis of Mibelli, punctate porokeratosis, porokeratosis palmaris et plantaris disseminata, and disseminated superficial porokeratosis. The eruptive form of porokeratosis is associated with malignancy, immunosuppression, and a proinflammatory state. Risk factors for porokeratosis include genetics, immunosuppression, and ultraviolet light. The lesions in disseminated superficial actinic porokeratosis start as pink to brown papules and macules with a raised border in sun-exposed areas that can be asymptomatic or slightly pruritic. There are many options for the treatment of disseminated superficial actinic porokeratosis, including topical diclofenac, photodynamic therapy (PDT), 5-fluorouracil (5-FU), imiquimod, vitamin D analogs, retinoids, and lasers. These lesions are considered precancerous. There is a 7.5 to 10% risk of malignant transformation to squamous cell carcinoma or basal cell carcinoma.
هڪ 52 سالن جو ماڻهو، اڳ ۾ صحتمند هو، پنهنجي چوٿين پير جي پڇاڙيءَ تي هڪ فليٽ، انگوزي جي شڪل واري پيچ سان اندر آيو، جيڪو 2 سالن کان بغير ڪنهن علامت جي موجود هو. اهو هڪ ننڍڙو، سخت ٽمپ وانگر شروع ٿيو ۽ وقت سان گڏ ٻاهر وڌيو. ڪوشش ڪرڻ جي باوجود مختلف علاج جهڙوڪ ڪريوٿراپي، ڪريم، اينٽي فنگل ۽ اينٽي بايوٽڪ، پيچ بهتر نه ٿيو. ڊرموڪوپسيءَ سان ان کي ويجهڙائي سان جانچڻ سان هڪ سڪل، ڳاڙهي مرڪز ڏيکاريو ويو، جنهن ۾ ٿلهي، ٿلهي سرحد هئي. چمڙي جو هڪ ننڍڙو ٽڪرو پيچ جي ڪنڊ کان ورتو ويو، چمڙي جي ٻاهرئين پرت ۾ غير معمولي سيل جي واڌ ڏيکاري ٿي، porokeratosis of Mibelli جي تشخيص جي تصديق ڪري ٿي.
A 52-year-old man with no past medical history presented with an asymptomatic annular atrophic patch on the distal portion of the fourth toe of 2 years’ duration. The lesion began as a small keratotic papule that gradually enlarged centrifugally. He had received multiple treatments including cryotherapy, topical corticosteroids, antifungals, and antibiotics without improvement. Dermoscopic examination revealed a scaly atrophic erythematous central area with a sharply demarcated peripheral hyperkeratotic structure. A skin biopsy of the edge of the lesion revealed a cornoid lamella with a column of parakeratotic cells extending from an invagination of the epidermis with absence of granular layer. The clinicopathologic correlation was consistent with porokeratosis of Mibelli.
A 52-year-old man with no past medical history presented with an asymptomatic annular atrophic patch on the distal portion of the fourth toe of 2 years’ duration. The lesion began as a small keratotic papule that gradually enlarged centrifugally. He had received multiple treatments including cryotherapy, topical corticosteroids, antifungals, and antibiotics without improvement. Dermoscopic examination revealed a scaly atrophic erythematous central area with a sharply demarcated peripheral hyperkeratotic structure. A skin biopsy of the edge of the lesion revealed a cornoid lamella with a column of parakeratotic cells extending from an invagination of the epidermis with absence of granular layer. The clinicopathologic correlation was consistent with porokeratosis of Mibelli.
گهڻو ڪري هڪ بايوپسي ڪئي ويندي آهي ڇاڪاڻ ته اهو ڏسڻ ۾ اچي سگهي ٿو ايڪٽينڪ keratosis يا squamous cell carcinoma.