Syphilis - سيفيلس
☆ 2022 ۾ جرمني مان Stiftung Warentest نتيجن، ModelDerm سان صارفين جي اطمينان صرف ادا ڪيل ٽيلي ميڊيسن مشوري جي ڀيٽ ۾ ٿورو گهٽ هئي.
Chancres ― پرائمري سيفيليٽڪ انفيڪشن Treponema pallidum
References
سيفيلس هڪ جنسي طور منتقل ٿيندڙ بيماري آهي جيڪا بيڪٽيريا Treponema pallidum جي ڪري ٿي. هن مطالعي ۾، اسان 18-68 سالن جي عمر جي 57 مريضن تي ثانوي سيفيلس سان گڏ.
Venereal syphilis is a multi-stage, sexually transmitted disease caused by the spirochetal bacterium Treponema pallidum (Tp). Herein we describe a cohort of 57 patients (age 18-68 years) with secondary syphilis (SS) identified through a network of public sector primary health care providers in Cali, Colombia.
Venereal syphilis is a multi-stage, sexually transmitted disease caused by the spirochetal bacterium Treponema pallidum (Tp). Herein we describe a cohort of 57 patients (age 18-68 years) with secondary syphilis (SS) identified through a network of public sector primary health care providers in Cali, Colombia.
Syphilis هڪ بيڪٽيريا انفيڪشن آهي جيڪو Treponema pallidum جي ڪري آهي. اهو مختلف بيمارين کي نقل ڪري سگهي ٿو، ان کي لقب great imitator حاصل ڪري ٿو. سيفيلس اڃا تائين عالمي سطح تي لکين ماڻهن کي متاثر ڪري ٿو پر پينسلين سان مؤثر طريقي سان علاج ڪري سگهجي ٿو.
Syphilis is a systemic bacterial infection caused by the spirochete Treponema pallidum. Due to its many protean clinical manifestations, it has been named the “great imitator and mimicker.” Syphilis remains a contemporary plague that continues to afflict millions of people worldwide. Luckily, the causative organism is still sensitive to penicillin.
Syphilis is a systemic bacterial infection caused by the spirochete Treponema pallidum. Due to its many protean clinical manifestations, it has been named the “great imitator and mimicker.” Syphilis remains a contemporary plague that continues to afflict millions of people worldwide. Luckily, the causative organism is still sensitive to penicillin.
Treponema pallidum حمل دوران جنسي رابطي ذريعي يا ماء کان ٻار تائين سيفيلس جو سبب بڻجندو آهي. جيتوڻيڪ ان جي تشخيص ڪرڻ لاءِ سادا ٽيسٽ موجود آهن ۽ هڪ ڊگهي ڪم ڪندڙ پينسلين شاٽ سان علاج سٺو ڪم ڪري ٿو، سيفيلس هڪ ڀيرو ٻيهر سڄي دنيا ۾ هڪ وڏو مسئلو بڻجي رهيو آهي. اهو خاص طور تي انهن مردن جي وچ ۾ سچو آهي جيڪي اعلي ۽ وچين آمدني وارن ملڪن ۾ مردن (MSM) سان جنسي تعلق رکن ٿا. جڏهن ته ڪجهه گهٽ آمدني وارن ملڪن WHO جا مقصد پورا ڪيا آهن ته جيئن ماءُ کان ٻار ڏانهن سيفيلس جي منتقلي کي روڪي سگهجي، اتي ايڇ آءِ وي-مثبت MSM جي وچ ۾ سيفيلس ۾ هڪ پريشان ڪندڙ اضافو آهي.
Treponema pallidum subspecies pallidum (T. pallidum) causes syphilis via sexual exposure or via vertical transmission during pregnancy. Despite the availability of simple diagnostic tests and the effectiveness of treatment with a single dose of long-acting penicillin, syphilis is re-emerging as a global public health problem, particularly among men who have sex with men (MSM) in high-income and middle-income countries. Although several low-income countries have achieved WHO targets for the elimination of congenital syphilis, an alarming increase in the prevalence of syphilis in HIV-infected MSM serves as a strong reminder of the tenacity of T. pallidum as a pathogen.
Treponema pallidum subspecies pallidum (T. pallidum) causes syphilis via sexual exposure or via vertical transmission during pregnancy. Despite the availability of simple diagnostic tests and the effectiveness of treatment with a single dose of long-acting penicillin, syphilis is re-emerging as a global public health problem, particularly among men who have sex with men (MSM) in high-income and middle-income countries. Although several low-income countries have achieved WHO targets for the elimination of congenital syphilis, an alarming increase in the prevalence of syphilis in HIV-infected MSM serves as a strong reminder of the tenacity of T. pallidum as a pathogen.
(1) وڌايل جگر: اهو اڪثر ملي ٿو ۽ ٿي سگهي ٿو هڪ وڌايل اسپين سان گڏ. جگر جي بايوپسي جي جانچ ڪندي ڊارڪ فيلڊ خوردبيني جي تحت اسپيروڪيٽ جي موجودگي کي ظاهر ڪري سگھي ٿي. ليور فنڪشن ٽيسٽ شايد غير معمولي ڏيکاري ٿي. (2) جلد جو پيلو ٿيڻ (Jaundice) : ڪنهن کي يرقان ظاهر ٿئي ٿو يا نه ان جو دارومدار ان تي آهي ته جگر ڪيترو متاثر ٿيو آهي. (3) وهندڙ نڪ: گهڻو ڪري پهرين نشانين مان هڪ، عام طور تي پيدائش کان پهرين هفتي اندر. (4) سوجن لفف نوڊس: عام طور تي لفف نوڊس جي سوجن، عام طور تي بي درد، پڻ عام آهي. (5) چمڙيءَ تي ريش: رَش عام طور تي وهندڙ نڪ کان هڪ کان ٻه هفتا پوءِ ظاهر ٿئي ٿي. توهان شايد پٺيءَ تي ننڍڙا ڳاڙها يا گلابي داغ ڏسي سگهو ٿا، ٿلها، ران، ۽ پيرن جي تلون. هي ريش ترقي ڪري سگهي ٿو ڇڪڻ ۽ ڪرسٽنگ تائين.
(1) Hepatomegaly: This is the most common finding and may occur with splenomegaly. Biopsy of the liver followed by darkfield microscopy may reveal the spirochete. Liver function tests may be abnormal. (2) Jaundice: Jaundice may or may not be present depending on the extent of liver injury. (3) Rhinitis: One of the first clinical presentations, usually in the first week of life. Copious, persistent white discharge is noted, which contains spirochetes that can be visualized under darkfield microscopy. (4) Generalized Lymphadenopathy: Generalized, non-tender lymphadenopathy is also a common finding. (5) Rash: Rash usually appears one to two weeks after rhinitis. Small red or pink colored maculopapular lesions may be commonly seen on the back, buttocks, posterior thigh and soles of the feet. The rash progresses to desquamation and crusting.
(1) Hepatomegaly: This is the most common finding and may occur with splenomegaly. Biopsy of the liver followed by darkfield microscopy may reveal the spirochete. Liver function tests may be abnormal. (2) Jaundice: Jaundice may or may not be present depending on the extent of liver injury. (3) Rhinitis: One of the first clinical presentations, usually in the first week of life. Copious, persistent white discharge is noted, which contains spirochetes that can be visualized under darkfield microscopy. (4) Generalized Lymphadenopathy: Generalized, non-tender lymphadenopathy is also a common finding. (5) Rash: Rash usually appears one to two weeks after rhinitis. Small red or pink colored maculopapular lesions may be commonly seen on the back, buttocks, posterior thigh and soles of the feet. The rash progresses to desquamation and crusting.
○ تشخيص ۽ علاج
وي ڊي آر ايل ۽ آر پي آر استعمال ڪري سگھجن ٿا تازو انفيڪشن جي تصديق ڪرڻ ۽ سيفيلس لاءِ اسڪرين. FTA-ABS ٽيسٽ هڪ وڌيڪ مخصوص ٽيسٽ آهي ۽ استعمال ڪري سگهجي ٿو پوئين انفيڪشن جي تاريخ جي جانچ ڪرڻ لاءِ. پينسلين سيفيلس جي علاج لاء استعمال ڪيو ويندو آهي.