Urticaria pigmentosa
Urticaria pigmentosa سڀ کان عام قسم جي چمڙي جي ماسٽوسائيٽوسس آهي. اها نادر بيماري آهي جيڪا چمڙي ۾ ماسٽ سيلن جي تمام گهڻي تعداد سبب ٿيندي آهي، جيڪا خارش يا سوزش پيدا ڪري ٿي. ڳاڙها يا ناسي داغ اڪثر ڪري چمڙي تي نظر اچن ٿا، عام طور تي سينه، پيشاني ۽ پوئتي جي چوڌاري. جڏهن اهي ماسٽ سيلز جلن ٿين ٿا (مثال طور چمڙي کي رڱڻ، گرميءَ جي نمائش)، اهي تمام گهڻو هسٽامائن ڇڏيندا آهن، جيڪو الرجڪ ردعمل جو سبب بڻجي ٿو ۽ جلن واري علائقي ۾ hives مقامي ٿي وڃن ٿا، جن کي ڪڏهن ڪڏهن “ڊيئر جي نشاني” به چيو ويندو آهي.
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ReferencesMastocytosis هڪ حالت آهي جتي mast cells جي اضافي ٿيندي آهي، اڪثر جسم جي مختلف حصن جهڙوڪ چمڙي، هڏن جي ميرو، ۽ هاضمي نظام ۾ ملن ٿا. ورلڊ هيلٿ آرگنائيزيشن (ڊبليو ايڇ او) جي مطابق، cutaneous mastocytosis کي ٽن مکيه قسمن ۾ ورهائي سگهجي ٿو. پهريون قسم (mastocytomas) اڪيلائي يا ڪجهه (≤3) زخمن تي مشتمل آهي. ٻيو قسم (urticaria pigmentosa) ۾ گھڻا زخم شامل آهن، عام طور تي 10 کان وڌيڪ ۽ 100 کان گھٽ تائين. آخري قسم سڄي چمڙي ۾ وسيع شموليت ڏيکاري ٿو. Urticaria pigmentosa ٻارن ۾ چمڙي جي mastocytosis جو سڀ کان عام روپ آهي، پر اهو بالغن ۾ پڻ ٿي سگهي ٿو. اها عام طور تي بي ضرر حالت آهي جيڪا اڪثر نوجوانن جي دوران بهتر ٿي ويندي آهي. بالغ mastocytosis جي برعڪس، urticaria pigmentosa گهٽ ۾ گهٽ اندروني عضون کي متاثر ڪري ٿو. Urticaria pigmentosa جي خاص خصوصيت اها آهي ته ان جي چمڙي تي ننڍڙا، خارش ڪندڙ، ڳاڙها يا پيلا ناسي رنگ جا داغ يا زخم پيدا ٿين ٿا، جن کي عام طور تي hives سڏيو ويندو آهي. اهي داغ اڪثر ننڍپڻ ۾ ظاهر ٿيندا آهن ۽ سڄي زندگي برقرار رهن ٿا.
Mastocytosis is a disorder characterized by mast cell accumulation, commonly in the skin, bone marrow, gastrointestinal (GI) tract, liver, spleen, and lymphatic tissues. The World Health Organization (WHO) divides cutaneous mastocytosis into 3 main presentations. The first has solitary or few (≤3) lesions called mastocytomas. The second, urticaria pigmentosa (UP), involves multiple lesions ranging from >10 to <100 lesions. The last presentation involves diffuse cutaneous involvement. UP is the most common cutaneous mastocytosis in children, but it can form in adults as well. It is considered a benign, self-resolving condition that often remits in adolescence. Unlike adult forms of mastocytosis, there is rarely any internal organ involvement in UP. What makes UP particularly distinctive is its tendency to manifest as small, itchy, reddish-brown, or yellowish-brown spots or lesions on the skin, commonly referred to as urticaria or hives. These spots typically appear in childhood and can persist throughout a person's life.
Mastocytosis is a disorder characterized by mast cell accumulation, commonly in the skin, bone marrow, gastrointestinal (GI) tract, liver, spleen, and lymphatic tissues. The World Health Organization (WHO) divides cutaneous mastocytosis into 3 main presentations. The first has solitary or few (≤3) lesions called mastocytomas. The second, urticaria pigmentosa (UP), involves multiple lesions ranging from >10 to <100 lesions. The last presentation involves diffuse cutaneous involvement. UP is the most common cutaneous mastocytosis in children, but it can form in adults as well. It is considered a benign, self-resolving condition that often remits in adolescence. Unlike adult forms of mastocytosis, there is rarely any internal organ involvement in UP. What makes UP particularly distinctive is its tendency to manifest as small, itchy, reddish-brown, or yellowish-brown spots or lesions on the skin, commonly referred to as urticaria or hives. These spots typically appear in childhood and can persist throughout a person's life.
هڪ 6 سالن جي ڇوڪري آئي، جنهن جي چمڙي تي ڪيترائي ڪارا رنگ جا داغ ظاهر ٿيا. اهي داغ پهريان صرف چمڙي تي هئا، پر گذريل ڇهن مهينن دوران منهن ۽ جسم تي پکڙجي ويا. جڏهن دٻاءُ لاڳو ڪيو ويو ته داغ اٿڻ، ڳاڙهي ٿيڻ ۽ خارش محسوس ڪندا. هن کي فلشنگ، الٽي، اسهرا يا گھرگھڻ جو ڪو تجربو نه هو، ۽ ذاتي يا خانداني طبي تاريخ سان لاڳاپيل ڪو اشارو مهيا نه ڪيو. جانچ دوران، ڳچي، پيشاني، منهن ۽ ڳچيءَ تي ڪيترائي اونداهي داغ ڏٺا، ۽ سيني ۽ پٺيءَ تي ٿورڙا اونداهي داغن جا نشان موجود هئا. داغن تي هلڪو رڱڻ لاڳو ڪرڻ سان 2 منٽ اندر سوجن ۽ خارش شروع ٿي، پر 15‑20 منٽ اندر علامتون ختم ٿي ويون (Darier's sign).
A 6-year-old female, presented with multiple dark-colored lesions, which started over the scalp and further progressed to involve the face and trunk since past six months. She gave a history of elevation, redness, and itching on the lesions on application of pressure. There was no associated flushing, vomiting, diarrhoea, or wheeze. The personal and family history was not contributory. On examination, there were multiple hyperpigmented macules over the scalp, forehead, face, and neck in addition to minimally elevated hyperpigmented plaques over the chest and the back. Gentle rubbing of the lesions elicited urtication and itching within 2 min and it resolved within 15–20 minutes, suggestive of the Darier's sign.
A 6-year-old female, presented with multiple dark-colored lesions, which started over the scalp and further progressed to involve the face and trunk since past six months. She gave a history of elevation, redness, and itching on the lesions on application of pressure. There was no associated flushing, vomiting, diarrhoea, or wheeze. The personal and family history was not contributory. On examination, there were multiple hyperpigmented macules over the scalp, forehead, face, and neck in addition to minimally elevated hyperpigmented plaques over the chest and the back. Gentle rubbing of the lesions elicited urtication and itching within 2 min and it resolved within 15–20 minutes, suggestive of the Darier's sign.
