Lupus erythematosus
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Vyzerá ako mierne purpurový erytém.
Motýlia vyrážka, ktorá sa zvyčajne objavuje na tvári.
References
Identifikácia a klasifikácia cutaneous lupus erythematosus (CLE) predstavuje diagnostické problémy, čím sa odlišuje od systemic lupus erythematosus s postihnutím kože. Nedávne štúdie objasňujú genetické, environmentálne a imunologické faktory, ktoré sú základom CLE. Indukcia liekov sa konkrétne ukázala ako jeden z najdôležitejších spúšťačov CLE. Liečba zahŕňa lokálne a systémové terapie, vrátane sľubných biologických liekov, ako je belimumab, rituximab, ustekinumab, anifrolumab, and BIIB059 , s preukázanou účinnosťou v klinických štúdiách.
Diagnostic challenges exist in better defining cutaneous lupus erythematosus (CLE) as an independent disease distinct from systemic lupus erythematosus with cutaneous features and further classifying CLE based on clinical, histological, and laboratory features. Recent mechanistic studies revealed more genetic variations, environmental triggers, and immunologic dysfunctions that are associated with CLE. Drug induction specifically has emerged as one of the most important triggers for CLE. Treatment options include topical agents and systemic therapies, including newer biologics such as belimumab, rituximab, ustekinumab, anifrolumab, and BIIB059 that have shown good clinical efficacy in trials.
Diagnostic challenges exist in better defining cutaneous lupus erythematosus (CLE) as an independent disease distinct from systemic lupus erythematosus with cutaneous features and further classifying CLE based on clinical, histological, and laboratory features. Recent mechanistic studies revealed more genetic variations, environmental triggers, and immunologic dysfunctions that are associated with CLE. Drug induction specifically has emerged as one of the most important triggers for CLE. Treatment options include topical agents and systemic therapies, including newer biologics such as belimumab, rituximab, ustekinumab, anifrolumab, and BIIB059 that have shown good clinical efficacy in trials.
Cutaneous lupus erythematosus (CLE) pokrýva rôzne kožné problémy, z ktorých niektoré môžu súvisieť so širšími zdravotnými problémami. Je kategorizovaný do rôznych typov, ako napríklad acute CLE (ACLE) , sub-acute CLE (SCLE) , and chronic CLE (CCLE) . CCLE obsahuje discoid lupus erythematosus (DLE) , LE profundus (LEP) , chilblain cutaneous lupus, and lupus tumidus.
Cutaneous lupus erythematosus (CLE) encompasses a wide range of dermatologic manifestations, which may or may not be associated with the development of systemic disease. Cutaneous lupus is divided into several sub-types, including acute CLE (ACLE), sub-acute CLE (SCLE) and chronic CLE (CCLE). CCLE includes discoid lupus erythematosus (DLE), LE profundus (LEP), chilblain cutaneous lupus and lupus tumidus.
Cutaneous lupus erythematosus (CLE) encompasses a wide range of dermatologic manifestations, which may or may not be associated with the development of systemic disease. Cutaneous lupus is divided into several sub-types, including acute CLE (ACLE), sub-acute CLE (SCLE) and chronic CLE (CCLE). CCLE includes discoid lupus erythematosus (DLE), LE profundus (LEP), chilblain cutaneous lupus and lupus tumidus.
Lupus erythematosus je skupina autoimunitných ochorení, ktoré môžu postihnúť rôzne časti tela. Niektoré typy, ako systemic lupus erythematosus (SLE) , postihujú viaceré orgány, zatiaľ čo iné, ako cutaneous lupus erythematosus (CLE) , postihujú najmä kožu. Rôzne typy CLE kategorizujeme na základe kombinácie klinických príznakov, vyšetrenia tkaniva a krvných testov, ale medzi jednotlivcami existuje veľa rozdielov. Kožné problémy sa často vyvíjajú v dôsledku faktorov, ako je vystavenie slnečnému žiareniu, fajčenie alebo určité lieky.
Lupus erythematosus comprises a spectrum of autoimmune diseases that may affect various organs (systemic lupus erythematosus [SLE]) or the skin only (cutaneous lupus erythematosus [CLE]). Typical combinations of clinical, histological and serological findings define clinical subtypes of CLE, yet there is high interindividual variation. Skin lesions arise in the course of triggers such as ultraviolet (UV) light exposure, smoking or drugs
Lupus erythematosus comprises a spectrum of autoimmune diseases that may affect various organs (systemic lupus erythematosus [SLE]) or the skin only (cutaneous lupus erythematosus [CLE]). Typical combinations of clinical, histological and serological findings define clinical subtypes of CLE, yet there is high interindividual variation. Skin lesions arise in the course of triggers such as ultraviolet (UV) light exposure, smoking or drugs
Príčina lupus erythematosus nie je jasná. Medzi jednovaječnými dvojčatami, ak je postihnuté jedno, je 24% šanca, že druhé bude tiež. Predpokladá sa, že toto riziko zvyšujú aj ženské pohlavné hormóny, slnečné žiarenie, fajčenie, nedostatok vitamínu D a niektoré infekcie.
Liečba môže zahŕňať NSAID, kortikosteroidy, imunosupresíva, hydroxychlorochín a metotrexát. Hoci sú kortikosteroidy účinné, dlhodobé užívanie má za následok vedľajšie účinky.