Melasma - Melazma
☆ Vo výsledkoch Stiftung Warentest z Nemecka za rok 2022 bola spokojnosť spotrebiteľov s ModelDerm len o niečo nižšia ako s platenými telemedicínskymi konzultáciami.
Ide o bežný stav pozorovaný u ázijských žien vo veku okolo 40 rokov. Zakrúžkovaná lézia na fotografii je bližšie k lentigu ako k melazme.
References
Tranexamic acid is a novel treatment option for melasma; however, there is no consensus on its use. This systematic review searched major databases for relevant publications to March 2016. Eleven studies with 667 participants were included. Pooled data from tranexamic acid-only observational studies with pre- and post-treatment Melasma Area and Severity Index (MASI) showed a decrease of 1.60 in MASI after treat?ment with tranexamic acid. The addition of tranexamic acid to routine treatment modalities resulted in a further decrease in MASI of 0.94. These results support the efficacy and safety of tranexamic acid, either alone or as an adjuvant to routine treatment modalities for melasma.
V poslednej dobe sa low-fluence Q-switched Nd:YAG (LFQSNY) laser stal populárnym na liečbu melazmy, najmä v Ázii. Zhrnutie rôznych štúdií bolo náročné, ale zdá sa, že LFQSNY je vo všeobecnosti účinný a bezpečný pre melazmu v porovnaní s tradičnými terapiami. Niektoré prípady škvrnitej hypopigmentácie však boli hlásené ako vedľajší účinok LFQSNY, pravdepodobne v dôsledku vysokej laserovej energie. Agresívne používanie LFQSNY môže tiež viesť k hyperpigmentácii zo zápalu, najmä pri tmavších odtieňoch pleti.
Recently, the low-fluence Q-switched Nd:YAG laser (LFQSNY) has been widely used for treating melasma, especially in Asia. It was hard to summarize the heterogenous studies, but LFQSNY appeared to be a generally effective and safe treatment for melasma considering the results of previous conventional therapies. However, mottled hypopigmentation has been occasionally reported to develop and persist as an adverse event of LFQSNY, which may be associated with the high accumulated laser energy. When used aggressively, even LFQSNY can induce hyperpigmentation via unwanted inflammation, especially in darker skin.
Recently, the low-fluence Q-switched Nd:YAG laser (LFQSNY) has been widely used for treating melasma, especially in Asia. It was hard to summarize the heterogenous studies, but LFQSNY appeared to be a generally effective and safe treatment for melasma considering the results of previous conventional therapies. However, mottled hypopigmentation has been occasionally reported to develop and persist as an adverse event of LFQSNY, which may be associated with the high accumulated laser energy. When used aggressively, even LFQSNY can induce hyperpigmentation via unwanted inflammation, especially in darker skin.
Problémy s pigmentáciou sa často vyskytujú v primárnej starostlivosti. Bežné typy porúch hyperpigmentácie zahŕňajú post-inflammatory hyperpigmentation, melasma, sunspots, freckles, and café au lait spots.
Pigmentation problems are often found in primary care. Common types of hyperpigmentation disorders include post-inflammatory hyperpigmentation, melasma, sunspots, freckles, café au lait spots.
Pigmentation problems are often found in primary care. Common types of hyperpigmentation disorders include post-inflammatory hyperpigmentation, melasma, sunspots, freckles, café au lait spots.
Melasma sa nedá do určitej doby vyriešiť laserovým ošetrením, keďže ide o ochorenie, pri ktorom sa kontinuálne tvorí pigment. Kyselina tranxenemová pomáha zlepšovať a znižovať pigmentáciu.
○ Liečba
V niektorých krajinách (napr. Japonsko, Kórea) je perorálna kyselina tranexamová voľne dostupná a je účinná. Melasma krém s kyselinou tranexamovou a kyselinou azelaovou môže byť čiastočne nápomocný.
Hydrochinón sa môže používať lokálne na liečbu hyperpigmentácie, ale FDA zastavila OTC produkty obsahujúce hydrochinón od roku 2020.
#Tranexamic acid [TRANSINO]
#Laser toning technique (low fluence QS1064 laser)
#Triluma