Amyloidosis - Amiloidoza
☆ V rezultatih raziskave Stiftung Warentest iz Nemčije leta 2022 je bilo zadovoljstvo potrošnikov z ModelDermom le nekoliko nižje kot s plačanimi telemedicinskimi svetovanji.
Klasične poteze obraza Amiloidoza (Amyloidosis)
References
V našo ambulanto je prišla 26-letna ženska, ki se je pritoževala nad srbečim izpuščajem na nogah, ki ga je imela že 10 let. Kljub uporabi steroidnih krem in kreme s tazarotenom se izpuščaj ni izboljšal. Ni imela ustrezne družinske anamneze. Ko smo jo pregledali, smo na sprednji strani njenih nog našli dvignjene, hrapave zaplate, ki so ustrezale bolezni, imenovani lichen amyloidosis.
A 26-year-old woman presented to our clinic with an itchy rash on her legs that had persisted for 10 years. The rash had previously been treated with topical steroids and tazarotene cream, with no improvement. The patient’s family history was noncontributory. A physical examination showed discrete and coalescing hyperkeratotic tan-brown papules on the pretibial surfaces, consistent with lichen amyloidosis.
A 26-year-old woman presented to our clinic with an itchy rash on her legs that had persisted for 10 years. The rash had previously been treated with topical steroids and tazarotene cream, with no improvement. The patient’s family history was noncontributory. A physical examination showed discrete and coalescing hyperkeratotic tan-brown papules on the pretibial surfaces, consistent with lichen amyloidosis.
Lichen Amyloidosis je redka kožna bolezen, povezana s trdovratnim srbenjem neznanega vzroka. Običajno se kaže kot skupki dvignjenih, razbarvanih lis na zunanjih površinah kože. Lichen Amyloidosis se običajno pojavi pri ljudeh, starih od 50 do 60 let, in na žalost zanj ni zdravila. Zdravljenja, ki so zdaj na voljo, običajno ne delujejo dobro.
Lichen Amyloidosis (LA) is an uncommon, primary cutaneous amyloidosis associated with chronic, idiopathic pruritus. Clinical presentation of LA includes skin colored to hyperpigmented, papules coalescing into plaques with a rippled appearance on the extensors.1 LA most commonly presents in the fifth to sixth decade of life and has no curative treatments. Overall response to current therapies is poor.
Lichen Amyloidosis (LA) is an uncommon, primary cutaneous amyloidosis associated with chronic, idiopathic pruritus. Clinical presentation of LA includes skin colored to hyperpigmented, papules coalescing into plaques with a rippled appearance on the extensors.1 LA most commonly presents in the fifth to sixth decade of life and has no curative treatments. Overall response to current therapies is poor.
Lichen amyloidosis je dolgotrajno srbeče stanje kože. Znan je po skupinah zadebeljenih izboklin, ki jih najdemo predvsem na hrbtu, golenih, stegnih in rokah. Ko ga pregledamo pod mikroskopom, Lichen amyloidosis pokaže kopičenje amiloida v zgornji plasti kože skupaj z odebelitvijo in povečanjem zunanje plasti kože. Čeprav natančen vzrok Lichen amyloidosis še ni povsem pojasnjen, so ga prejšnje študije med drugim povezale z dejavniki, kot so drgnjenje ali trenje kože, odmiranje celic, virusne okužbe. Zdi se, da je Lichen amyloidosis povezan z več drugimi kožnimi boleznimi, kot je atopic dermatitis, lichen planus, and mycosis fungoides.
Lichen amyloidosis (LA) is a chronic pruritic skin disorder characterized by multiple grouped hyperkeratotic papules, predominantly located on the back, shins, thighs, and arms. Histological analysis of LA shows amyloid deposition in the papillary dermis and hyperkeratosis and acanthosis of the epidermis. The exact pathogenesis of LA has not yet been elucidated; however, prior reports have implicated frictional epidermal damage, apoptosis, viral infection, and many other triggers. LA is reportedly associated with several skin disorders, including atopic dermatitis (AD), lichen planus, and mycosis fungoides.
Lichen amyloidosis (LA) is a chronic pruritic skin disorder characterized by multiple grouped hyperkeratotic papules, predominantly located on the back, shins, thighs, and arms. Histological analysis of LA shows amyloid deposition in the papillary dermis and hyperkeratosis and acanthosis of the epidermis. The exact pathogenesis of LA has not yet been elucidated; however, prior reports have implicated frictional epidermal damage, apoptosis, viral infection, and many other triggers. LA is reportedly associated with several skin disorders, including atopic dermatitis (AD), lichen planus, and mycosis fungoides.
○ Diagnoza in zdravljenje
#Electrophoresis of blood or urine
#Skin biopsy