Angiofibroma - Angiofibrom
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References
Cutaneous angiofibromas se lahko pojavi na različnih delih telesa. Na obrazu so pogosto znani kot fibrozne papule ali adenom sebaceum; na penisu se imenujejo pearly penile papules ; pod nohtom se imenujejo periungualni angiofibromi ali Koenenovi tumorji; in v ustih se imenujejo oralni fibromi. Obrazni angiofibromi so pomembna značilnost tuberous sclerosis (TS) , dedne bolezni, ki prizadene kožo, ledvice, srce, možgane in pljuča. Običajno se razvijejo na obrazu v otroštvu ali zgodnji odrasli dobi pri posameznikih s TS. Imeti tri ali več obraznih angiofibromov ali dva ali več periungualnih angiofibromov se šteje za pomembno pri diagnosticiranju TS. Poleg tega je lahko v stanjih (multiple endocrine neoplasia type 1 (MEN-1) in Birt-Hogg-Dubé syndrome) prisotnih več obraznih angiofibromov. Pearly penile papules najdemo vzdolž koronalnega roba in sulkusa penisa. So trdovratne, neboleče izbokline, ki jih pogosteje opazimo pri neobrezanih moških.
Cutaneous angiofibromas can be located on different areas of the body including the face where they are commonly called fibrous papules or adenoma sebaceum on the penis where they are called pearly penile papules, underneath the nail where they are called periungual angiofibromas or Koenen tumors, and in the mouth where they are called oral fibromas. Facial angiofibromas are considered one of the most obvious clinical presentations of tuberous sclerosis (TS), an autosomal dominant hamartomatous disorder that affects the skin, kidneys, heart, brain, and lungs. With TS, angiofibromas typically arise on the face in childhood and early adulthood. Both facial angiofibromas (greater than or equal to 3 needed) and periungual angiofibroma (greater than or equal to 2 needed) are 2 of the major criteria for TS. Multiple facial angiofibromas are also found in multiple endocrine neoplasia type 1 (MEN-1) and Birt-Hogg-Dube syndrome. Pearly penile papules are chronic, asymptomatic, papules found on the coronal margin and sulcus of the penis. They are more common in uncircumcised men.
Cutaneous angiofibromas can be located on different areas of the body including the face where they are commonly called fibrous papules or adenoma sebaceum on the penis where they are called pearly penile papules, underneath the nail where they are called periungual angiofibromas or Koenen tumors, and in the mouth where they are called oral fibromas. Facial angiofibromas are considered one of the most obvious clinical presentations of tuberous sclerosis (TS), an autosomal dominant hamartomatous disorder that affects the skin, kidneys, heart, brain, and lungs. With TS, angiofibromas typically arise on the face in childhood and early adulthood. Both facial angiofibromas (greater than or equal to 3 needed) and periungual angiofibroma (greater than or equal to 2 needed) are 2 of the major criteria for TS. Multiple facial angiofibromas are also found in multiple endocrine neoplasia type 1 (MEN-1) and Birt-Hogg-Dube syndrome. Pearly penile papules are chronic, asymptomatic, papules found on the coronal margin and sulcus of the penis. They are more common in uncircumcised men.
1) obraz
Fibrous papule
2) penis
Pearly penile papule
3) pod nohtom na roki ali nogi
Periungual angiofibroma