Drug eruption - Izbruh Drog
☆ V rezultatih raziskave Stiftung Warentest iz Nemčije leta 2022 je bilo zadovoljstvo potrošnikov z ModelDermom le nekoliko nižje kot s plačanimi telemedicinskimi svetovanji.
Za Izbruh Drog (Drug eruption) je značilno, da vpliva na celotno telo.
References
Kožne reakcije, ki jih povzročajo zdravila, znane kot izbruhi zdravila, so lahko včasih hude. Te hude reakcije, imenovane severe cutaneous adverse drug reactions (SCARs) , veljajo za življenjsko nevarne. Vključujejo pogoje, kot je Stevens-Johnson syndrome (SJS) , toxic epidermal necrolysis (TEN) , acute generalized exanthematous pustulosis (AGEP) , and drug reaction with eosinophilia and systemic symptoms (DRESS) . Čeprav so SCARs redki, jih doživi približno 2 % hospitaliziranih bolnikov.
Adverse drug reactions involving the skin are commonly known as drug eruptions. Severe drug eruption may cause severe cutaneous adverse drug reactions (SCARs), which are considered to be fatal and life-threatening, including Stevens-Johnson syndrome (SJS), toxic epidermal necrolysis (TEN), acute generalized exanthematous pustulosis (AGEP), and drug reaction with eosinophilia and systemic symptoms (DRESS). Although cases are relatively rare, approximately 2% of hospitalized patients are affected by SCARs.
Adverse drug reactions involving the skin are commonly known as drug eruptions. Severe drug eruption may cause severe cutaneous adverse drug reactions (SCARs), which are considered to be fatal and life-threatening, including Stevens-Johnson syndrome (SJS), toxic epidermal necrolysis (TEN), acute generalized exanthematous pustulosis (AGEP), and drug reaction with eosinophilia and systemic symptoms (DRESS). Although cases are relatively rare, approximately 2% of hospitalized patients are affected by SCARs.
31-letna ženska je obiskala dermatološki oddelek z nebolečo rdečo liso na zgornjem delu desnega stopala. Dan prej je vzela en odmerek doksiciklina (100 mg) po pikosekundnem laserskem zdravljenju brazgotin po aknah. Lansko leto je doživela podobno težavo na istem mestu, potem ko je vzela enak odmerek doksiciklina po laserskem zdravljenju. Nima pomembne zdravstvene anamneze in nobenih drugih simptomov, kot je vročina, lokalno ali po telesu.
A 31-year-old woman presented to the dermatology department with an asymptomatic erythematous patch on the dorsum of her right foot. She had taken 1 dose of doxycycline (100 mg) the previous day as empirical treatment after picosecond laser treatment for acne scars. She had had a similar episode the previous year on the same site, after taking the same dose of doxycycline after laser treatment. She had no notable medical history, and no other local or systemic symptoms, including fever.
A 31-year-old woman presented to the dermatology department with an asymptomatic erythematous patch on the dorsum of her right foot. She had taken 1 dose of doxycycline (100 mg) the previous day as empirical treatment after picosecond laser treatment for acne scars. She had had a similar episode the previous year on the same site, after taking the same dose of doxycycline after laser treatment. She had no notable medical history, and no other local or systemic symptoms, including fever.
Stevens-Johnson syndrome (SJS) in toxic epidermal necrolysis (TEN) sta dve obliki resne kožne reakcije, ki se razlikujeta od drugih kožnih stanj, kot sta multiformni eritem in stafilokokni sindrom opečene kože, ter od reakcij na zdravila. SJS/TEN je redka in huda reakcija, ki povzroča obsežno poškodbo kože in sluznice, pogosto s sistemskimi simptomi. V več kot 80% primerov so vzrok zdravila.
Stevens-Johnson syndrome (SJS), and toxic epidermal necrolysis (TEN) are variants of the same condition and are distinct from erythema multiforme major staphylococcal scalded skin syndrome, and other drug eruptions. Stevens-Johnson syndrome/toxic epidermal necrolysis is a rare, acute, serious, and potentially fatal skin reaction in which there are sheet-like skin and mucosal loss accompanied by systemic symptoms. Medications are causative in over 80% of cases.
Stevens-Johnson syndrome (SJS), and toxic epidermal necrolysis (TEN) are variants of the same condition and are distinct from erythema multiforme major staphylococcal scalded skin syndrome, and other drug eruptions. Stevens-Johnson syndrome/toxic epidermal necrolysis is a rare, acute, serious, and potentially fatal skin reaction in which there are sheet-like skin and mucosal loss accompanied by systemic symptoms. Medications are causative in over 80% of cases.
Izbruhi zdravila se diagnosticirajo predvsem na podlagi anamneze in kliničnega pregleda. Koristni so lahko tudi biopsija kože, krvni testi ali imunološki testi.
Primeri pogostih zdravil, ki povzročajo izbruh, so antibiotiki in druga protimikrobna zdravila, sulfanilamidna zdravila, nesteroidna protivnetna zdravila (NSAID), kemoterapevtska sredstva za maligne bolezni, antikonvulzivi in psihotropna zdravila.
○ Diagnoza in zdravljenje
Če imate vročino (povišano telesno temperaturo), morate čim prej poiskati zdravniško pomoč. Sumljivo zdravilo je treba prekiniti (npr. antibiotiki, nesteroidna protivnetna zdravila). Pred obiskom bolnišnice lahko peroralni antihistaminiki, kot sta cetirizin ali loratadin, pomagajo pri srbenju in izpuščaju.
#Cetirizine [Zytec]
#LevoCetirizine [Xyzal]
#Loratadine [Claritin]
Krvni test (CBC, LFT, število eozinofilcev)
Peroralni steroidi in antihistaminiki na zdravniški recept