Syphilis - Sifilis
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Chancres ― primarna sifilitična okužba z Treponema pallidum
References
Sifilis je spolno prenosljiva bolezen, ki jo povzroča bakterija Treponema pallidum. V tej študiji se osredotočamo na 57 bolnikov, starih od 18 do 68 let, s sekundarnim sifilisom.
Venereal syphilis is a multi-stage, sexually transmitted disease caused by the spirochetal bacterium Treponema pallidum (Tp). Herein we describe a cohort of 57 patients (age 18-68 years) with secondary syphilis (SS) identified through a network of public sector primary health care providers in Cali, Colombia.
Venereal syphilis is a multi-stage, sexually transmitted disease caused by the spirochetal bacterium Treponema pallidum (Tp). Herein we describe a cohort of 57 patients (age 18-68 years) with secondary syphilis (SS) identified through a network of public sector primary health care providers in Cali, Colombia.
Sifilis je bakterijska okužba, ki jo povzroča Treponema pallidum. Lahko posnema različne bolezni, zaradi česar si je prislužil vzdevek great imitator. Sifilis še vedno prizadene milijone po vsem svetu, vendar ga je mogoče učinkovito zdraviti s penicilinom.
Syphilis is a systemic bacterial infection caused by the spirochete Treponema pallidum. Due to its many protean clinical manifestations, it has been named the “great imitator and mimicker.” Syphilis remains a contemporary plague that continues to afflict millions of people worldwide. Luckily, the causative organism is still sensitive to penicillin.
Syphilis is a systemic bacterial infection caused by the spirochete Treponema pallidum. Due to its many protean clinical manifestations, it has been named the “great imitator and mimicker.” Syphilis remains a contemporary plague that continues to afflict millions of people worldwide. Luckily, the causative organism is still sensitive to penicillin.
Treponema pallidum povzroča sifilis s spolnim stikom ali z matere na otroka med nosečnostjo. Čeprav obstajajo preprosti testi za diagnosticiranje in zdravljenje z enim dolgo delujočim penicilinom dobro deluje, sifilis spet postaja velik problem po vsem svetu. To še posebej velja za moške, ki imajo spolne odnose z moškimi (MSM) v državah z visokimi in srednjimi dohodki. Medtem ko so nekatere države z nizkimi dohodki izpolnile cilje Svetovne zdravstvene organizacije za zaustavitev prenosa sifilisa z matere na otroka, je zaskrbljujoč porast sifilisa med HIV-pozitivnimi MSM.
Treponema pallidum subspecies pallidum (T. pallidum) causes syphilis via sexual exposure or via vertical transmission during pregnancy. Despite the availability of simple diagnostic tests and the effectiveness of treatment with a single dose of long-acting penicillin, syphilis is re-emerging as a global public health problem, particularly among men who have sex with men (MSM) in high-income and middle-income countries. Although several low-income countries have achieved WHO targets for the elimination of congenital syphilis, an alarming increase in the prevalence of syphilis in HIV-infected MSM serves as a strong reminder of the tenacity of T. pallidum as a pathogen.
Treponema pallidum subspecies pallidum (T. pallidum) causes syphilis via sexual exposure or via vertical transmission during pregnancy. Despite the availability of simple diagnostic tests and the effectiveness of treatment with a single dose of long-acting penicillin, syphilis is re-emerging as a global public health problem, particularly among men who have sex with men (MSM) in high-income and middle-income countries. Although several low-income countries have achieved WHO targets for the elimination of congenital syphilis, an alarming increase in the prevalence of syphilis in HIV-infected MSM serves as a strong reminder of the tenacity of T. pallidum as a pathogen.
(1) Povečana jetra: To se pogosto pojavi in se lahko pojavi skupaj s povečano vranico. Preiskava biopsije jeter pod temnopoljskim mikroskopom lahko razkrije prisotnost spirohete. Testi delovanja jeter lahko pokažejo nenormalnosti. (2) Porumenelost kože (zlatenica) : Ali ima nekdo zlatenico, je odvisno od tega, koliko so prizadeta jetra. (3) Izcedek iz nosu: pogosto eden od prvih znakov, običajno v prvem tednu po rojstvu. (4) Otekle bezgavke: pogosto je tudi generalizirano otekanje bezgavk, običajno neboleče. (5) Kožni izpuščaj: izpuščaj se običajno pojavi en do dva tedna po izcedku iz nosu. Morda boste opazili majhne rdeče ali rožnate lise na hrbtu, zadnjici, stegnih in podplatih. Ta izpuščaj lahko napreduje do luščenja in skorje.
(1) Hepatomegaly: This is the most common finding and may occur with splenomegaly. Biopsy of the liver followed by darkfield microscopy may reveal the spirochete. Liver function tests may be abnormal. (2) Jaundice: Jaundice may or may not be present depending on the extent of liver injury. (3) Rhinitis: One of the first clinical presentations, usually in the first week of life. Copious, persistent white discharge is noted, which contains spirochetes that can be visualized under darkfield microscopy. (4) Generalized Lymphadenopathy: Generalized, non-tender lymphadenopathy is also a common finding. (5) Rash: Rash usually appears one to two weeks after rhinitis. Small red or pink colored maculopapular lesions may be commonly seen on the back, buttocks, posterior thigh and soles of the feet. The rash progresses to desquamation and crusting.
(1) Hepatomegaly: This is the most common finding and may occur with splenomegaly. Biopsy of the liver followed by darkfield microscopy may reveal the spirochete. Liver function tests may be abnormal. (2) Jaundice: Jaundice may or may not be present depending on the extent of liver injury. (3) Rhinitis: One of the first clinical presentations, usually in the first week of life. Copious, persistent white discharge is noted, which contains spirochetes that can be visualized under darkfield microscopy. (4) Generalized Lymphadenopathy: Generalized, non-tender lymphadenopathy is also a common finding. (5) Rash: Rash usually appears one to two weeks after rhinitis. Small red or pink colored maculopapular lesions may be commonly seen on the back, buttocks, posterior thigh and soles of the feet. The rash progresses to desquamation and crusting.
○ Diagnoza in zdravljenje
VDRL in RPR se lahko uporabita za potrditev nedavne okužbe in presejanje sifilisa. Test FTA-ABS je bolj specifičen test in se lahko uporablja za preverjanje predhodne okužbe. Penicilin se uporablja za zdravljenje sifilisa.