Angiofibroma
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ReferencesCutaneous angiofibromas e mafai ona aliali i vaega eseese o le tino. I luga o foliga, e masani ona taʻua o papules fibrous poʻo le adenoma sebaceum; i luga o le penis, e igoa ia pearly penile papules; i lalo ifo o le fao, ua taʻua o periungual angiofibromas po o Koenen tumors; ma i totonu o le gutu, e taʻua o oral fibromas. Facial angiofibromas ose vaega iloga o tuberous sclerosis (TS), ose faaletonu tuufaasolo e aafia ai le pa'u, fatuga'o, fatu, fai'ai, ma mama. E masani ona tupu i luga o foliga i le taimi o le tamaitiiti poʻo le amataga o le matua i tagata taʻitoʻatasi ma TS. O le i ai o le tolu pe sili atu angiofibromas mata poʻo le lua pe sili atu angiofibromas periungual e manatu e taua i le suʻesuʻeina o le TS. E le gata i lea, e tele facial angiofibromas e ono iai i tulaga (multiple endocrine neoplasia type 1 (MEN-1) ma Birt-Hogg-Dube syndrome). Pearly penile papules e maua i le pito o le korona ma le sulcus o le penis. O chronic, asymptomatic papules, e leai se tiga e masani ona vaaia i tane e le'i peritomeina.
Cutaneous angiofibromas can be located on different areas of the body including the face where they are commonly called fibrous papules or adenoma sebaceum on the penis where they are called pearly penile papules, underneath the nail where they are called periungual angiofibromas or Koenen tumors, and in the mouth where they are called oral fibromas. Facial angiofibromas are considered one of the most obvious clinical presentations of tuberous sclerosis (TS), an autosomal dominant hamartomatous disorder that affects the skin, kidneys, heart, brain, and lungs. With TS, angiofibromas typically arise on the face in childhood and early adulthood. Both facial angiofibromas (greater than or equal to 3 needed) and periungual angiofibroma (greater than or equal to 2 needed) are 2 of the major criteria for TS. Multiple facial angiofibromas are also found in multiple endocrine neoplasia type 1 (MEN-1) and Birt-Hogg-Dube syndrome. Pearly penile papules are chronic, asymptomatic, papules found on the coronal margin and sulcus of the penis. They are more common in uncircumcised men.
Cutaneous angiofibromas can be located on different areas of the body including the face where they are commonly called fibrous papules or adenoma sebaceum on the penis where they are called pearly penile papules, underneath the nail where they are called periungual angiofibromas or Koenen tumors, and in the mouth where they are called oral fibromas. Facial angiofibromas are considered one of the most obvious clinical presentations of tuberous sclerosis (TS), an autosomal dominant hamartomatous disorder that affects the skin, kidneys, heart, brain, and lungs. With TS, angiofibromas typically arise on the face in childhood and early adulthood. Both facial angiofibromas (greater than or equal to 3 needed) and periungual angiofibroma (greater than or equal to 2 needed) are 2 of the major criteria for TS. Multiple facial angiofibromas are also found in multiple endocrine neoplasia type 1 (MEN-1) and Birt-Hogg-Dube syndrome. Pearly penile papules are chronic, asymptomatic, papules found on the coronal margin and sulcus of the penis. They are more common in uncircumcised men.
1) Faʻatatau i le foliga – papule fibrosa (Fibrous papule)
2) Penis – papule pene perili (Pearly penile papule)
3) I lalo o le atigilima po'o le atigilima – angiofibroma periungual (Periungual angiofibroma)