Fa'amatalaga atili ― Samoan

Erythema nodosum is the most common form of panniculitis and is characterized by tender erythematous nodules mainly in the lower limbs on the pretibial area. The exact cause of erythema nodosum is unknown, although it appears to be a hypersensitivity response to a variety of antigenic stimuli. Although the etiology is mostly idiopathic, ruling out an underlying disease is imperative before diagnosing primary erythema nodosum. Erythema nodosum can be the first sign of a systemic disease that is triggered by a large group of processes, such as infections, inflammatory diseases, neoplasia, and/or drugs. The most common identifiable causes are streptococcal infections, primary tuberculosis, sarcoidosis, Behçet disease, inflammatory bowel disease, drugs, and pregnancy.

Panniculitis fa'atupuina se vaega 'ese'ese o fa'ama'i fa'ama'i e a'afia ai le aano o le adipose subcutaneous. O nei faaletonu e seasea maua i tamaiti. O le panniculitis e mafai ona avea ma faiga muamua i se faʻafitauli faʻapitoa poʻo se gaioiga lona lua e mafua mai i faʻamaʻi, manua poʻo le faʻaalia i vailaʻau. O le tele o ituaiga o panniculitis e tutusa lava le fa'aaliga ile falema'i (tusa lava po'o le a le a'afiaga) , ma le vaivai, erythematous subcutaneous nodules.
Panniculitides form a heterogenous group of inflammatory diseases that involve the subcutaneous adipose tissue. These disorders are rare in children and have many aetiologies. As in adults, the panniculitis can be the primary process in a systemic disorder or a secondary process that results from infection, trauma or exposure to medication. Some types of panniculitis are seen more commonly or exclusively in children, and several new entities have been described in recent years. Most types of panniculitis have the same clinical presentation (regardless of the aetiology), with tender, erythematous subcutaneous nodules.

Panniculitis , fulafula o le ga'o i lalo o le pa'u, e masani ona maua i nodules inflammatory. Erythema nodosum (EN) o le fa'afoma'i o le fa'ama'i masani o panniculitis. A'o o'o atu i le 55% o le EN o lo'o ta'ua idiopathic, o mafua'aga sili ona taatele e aofia ai fa'ama'i, vaila'au, ma'i fa'apitoa e pei ole sarcoidosis ma fa'ama'i inflammatory bowel, ma'itaga, ma le ma'i. O le EN e masani lava ona maua i le tupulaga talavou ma le 20s, ma e masani ona vaaia i tamaitai. E masani ona muamua atu i se vaega e le fa'apitoa o le tasi i le tolu vaiaso, lea e ono aofia ai le fiva, malaise, ma fa'ailoga o se fa'ama'i pito i luga o le manava. Ona soso'o mai ai lea o manu'a pa'u, e masani lava ona fa'ailo i le itu fa'alatalata o vae. O manu'a e tiga lapotopoto po'o oval, fai sina si'i, nodules mumu e le'i tu'i. Le faʻamaʻi saʻo o le EN e leʻo malamalama, e ui lava e manatu e mafua mai i le tuʻuina atu o faʻalavelave faʻalavelave i totonu o venules o le septae i le gaʻo subcutaneous, e mafua ai le neutrophilic panniculitis. E tusa lava pe leai se togafitiga faʻapitoa mo se faʻamaʻi faʻamaʻi, EN e foia e aunoa ma se togafitiga i le tele o tulaga.
Panniculitis, inflammation of the subcutaneous fat, usually presents with inflammatory nodules. Erythema nodosum (EN) is clinically the most frequent form of panniculitis. Whilst up to 55% of EN is considered idiopathic, the most common causes include infections, drugs, systemic illnesses such as sarcoidosis and inflammatory bowel disease, pregnancy, and malignancy. EN typically presents in the teens and 20s, and is seen more commonly in females. It is often preceded by a non-specific prodrome of one to three weeks, which may include fever, malaise, and symptoms of an upper respiratory tract infection. Cutaneous lesions then follow, typically localized on the extensor aspect of the limbs. The lesions are painful rounded or oval, slightly raised, non-ulcerative red nodules. The exact pathogenesis of EN is not understood, although is thought to result from deposition of immune complexes in the venules of the septae in subcutaneous fat, causing a neutrophilic panniculitis. Even without specific therapy for a causative condition, EN resolves without treatment in most cases.