Porokeratosis
☆ AI Dermatology — Free Service
I le 2022 Stiftung Warentest i'uga mai Siamani, o le fa'amalieina o tagata fa'atau i ModelDerm sa na'o sina maualalo ifo nai lo fa'atalanoaga telemedicine totogi.
I le 2022 Stiftung Warentest i'uga mai Siamani, o le fa'amalieina o tagata fa'atau i ModelDerm sa na'o sina maualalo ifo nai lo fa'atalanoaga telemedicine totogi.
O le pito maʻaʻa e faʻaoso.
relevance score : -100.0%
ReferencesPorokeratosis o se ma'i e se'esea le fa'atuatuaga o le keratinization, ma e mafua ai le si'i, e pei o mama po'o ni patu talatala i le pa'u. O lona uiga, i lalo o le microscope, e mafai ona va'aia le i ai o le cornoid lamella, o se fa'atulagaga patino o sela i le pito i luga o le pa'u. Porokeratosis e sau i ituaiga eseese (disseminated superficial actinic porokeratosis, classical porokeratosis of Mibelli, porokeratosis palmaris plantaris et disseminatum, linear porokeratosis). E taua le maitauina o le porokeratosis ona e mafai ona tupu i le kanesa o le pa'u. O le auala sili e iloa ai le porokeratosis o le biopsy o le tuaoi si'i, e ui e le'i iai i le taimi nei se fa'ata'ita'iga masani o togafitiga.
Porokeratosis is an uncommon dermatologic disorder. It is a disorder of keratinization that presents with keratotic papules or annular plaques with an elevated border. It has a distinct histologic hallmark of cornoid lamella, which is a column of tightly fitted parakeratotic cells in the upper epidermis. There are multiple clinical variants of porokeratosis, including disseminated superficial actinic porokeratosis, classical porokeratosis of Mibelli, porokeratosis palmaris plantaris et disseminatum, and linear porokeratosis. Porokeratosis is a precancerous lesion that can undergo malignant transformation. Evaluation of porokeratosis is best with a biopsy of the elevated border. There are no standard guidelines for treatment.
Porokeratosis is an uncommon dermatologic disorder. It is a disorder of keratinization that presents with keratotic papules or annular plaques with an elevated border. It has a distinct histologic hallmark of cornoid lamella, which is a column of tightly fitted parakeratotic cells in the upper epidermis. There are multiple clinical variants of porokeratosis, including disseminated superficial actinic porokeratosis, classical porokeratosis of Mibelli, porokeratosis palmaris plantaris et disseminatum, and linear porokeratosis. Porokeratosis is a precancerous lesion that can undergo malignant transformation. Evaluation of porokeratosis is best with a biopsy of the elevated border. There are no standard guidelines for treatment.
Disseminated superficial actinic porokeratosis (DSAP) o se fa'ama'i o le keratinization fa'aletonu. O se ituaiga o porokeratosis, ma e masani ona aafia ai vaega tetele pe a faatusatusa i isi (linear, Mibelli's, punctate, palmoplantar disseminated, superficial porokeratosis). O le ituaiga pa o porokeratosis e masani ona feso'ota'i i le kanesa, fa'avaivaia le puipuiga, po'o le mumu. O a'afiaga e a'afia ai le kenera, fa'ata'ita'i puipuiga, ma le fa'aalia o le la. O le DSAP e amata i patupatu lanu pīniki pe enaena ma fa'ae'e pito i vaega e la'ia i le la, o nisi taimi e mafua ai sina mageso. O togafitiga e eseese ma e mafai ona aofia ai kulimi autu, togafitiga mama, poʻo vailaʻau e pei o le 5-fluorouracil poʻo retinoids. O nei mea ua manatu e le'i fa'amasani, ma e 7.5‑10 % le avanoa e liu ai i le squamous cell carcinoma po'o le basal cell carcinoma.
Disseminated superficial actinic porokeratosis (DSAP) is a disease of disordered keratinization. Disseminated superficial actinic porokeratosis is one of six variants of porokeratosis. It has more extensive involvement than most other variants. These other variants include linear porokeratosis, porokeratosis of Mibelli, punctate porokeratosis, porokeratosis palmaris et plantaris disseminata, and disseminated superficial porokeratosis. The eruptive form of porokeratosis is associated with malignancy, immunosuppression, and a proinflammatory state. Risk factors for porokeratosis include genetics, immunosuppression, and ultraviolet light. The lesions in disseminated superficial actinic porokeratosis start as pink to brown papules and macules with a raised border in sun-exposed areas that can be asymptomatic or slightly pruritic. There are many options for the treatment of disseminated superficial actinic porokeratosis, including topical diclofenac, photodynamic therapy (PDT), 5-fluorouracil (5-FU), imiquimod, vitamin D analogs, retinoids, and lasers. These lesions are considered precancerous. There is a 7.5 to 10% risk of malignant transformation to squamous cell carcinoma or basal cell carcinoma.
Disseminated superficial actinic porokeratosis (DSAP) is a disease of disordered keratinization. Disseminated superficial actinic porokeratosis is one of six variants of porokeratosis. It has more extensive involvement than most other variants. These other variants include linear porokeratosis, porokeratosis of Mibelli, punctate porokeratosis, porokeratosis palmaris et plantaris disseminata, and disseminated superficial porokeratosis. The eruptive form of porokeratosis is associated with malignancy, immunosuppression, and a proinflammatory state. Risk factors for porokeratosis include genetics, immunosuppression, and ultraviolet light. The lesions in disseminated superficial actinic porokeratosis start as pink to brown papules and macules with a raised border in sun-exposed areas that can be asymptomatic or slightly pruritic. There are many options for the treatment of disseminated superficial actinic porokeratosis, including topical diclofenac, photodynamic therapy (PDT), 5-fluorouracil (5-FU), imiquimod, vitamin D analogs, retinoids, and lasers. These lesions are considered precancerous. There is a 7.5 to 10% risk of malignant transformation to squamous cell carcinoma or basal cell carcinoma.
O se alii e 52 tausaga le matua, ua i ai le soifua maloloina muamua, na sau i totonu o se papa mafolafola, foliga mama i le pito o lona vae, lea na i ai i le 2 tausaga e aunoa ma se afaina. Na amata i se tama'i pa'u malō ma tupu a'e i fafo i le aluga o le taimi. E ui i le taumafai i togafitiga eseese e pei o le cryotherapy, kulimi, antifungals, ma vailaau faʻamaʻi, e leʻi toe fa'aleleina le pa'u. O le su'esu'eina fa'atasi ma le dermoscopy na fa'aalia ai se ogatotonu matutu, mumu ma se tuaoi mafiafia, talatala. O se fasi pa'u la'ititi na aumai mai le pito o le pa'u na fa'aalia ai le tupu a'e o le sela i fafo o le pa'u, ma fa'amaonia ai le su'esu'ega o le porokeratosis of Mibelli.
A 52-year-old man with no past medical history presented with an asymptomatic annular atrophic patch on the distal portion of the fourth toe of 2 years’ duration. The lesion began as a small keratotic papule that gradually enlarged centrifugally. He had received multiple treatments including cryotherapy, topical corticosteroids, antifungals, and antibiotics without improvement. Dermoscopic examination revealed a scaly atrophic erythematous central area with a sharply demarcated peripheral hyperkeratotic structure. A skin biopsy of the edge of the lesion revealed a cornoid lamella with a column of parakeratotic cells extending from an invagination of the epidermis with absence of granular layer. The clinicopathologic correlation was consistent with porokeratosis of Mibelli.
A 52-year-old man with no past medical history presented with an asymptomatic annular atrophic patch on the distal portion of the fourth toe of 2 years’ duration. The lesion began as a small keratotic papule that gradually enlarged centrifugally. He had received multiple treatments including cryotherapy, topical corticosteroids, antifungals, and antibiotics without improvement. Dermoscopic examination revealed a scaly atrophic erythematous central area with a sharply demarcated peripheral hyperkeratotic structure. A skin biopsy of the edge of the lesion revealed a cornoid lamella with a column of parakeratotic cells extending from an invagination of the epidermis with absence of granular layer. The clinicopathologic correlation was consistent with porokeratosis of Mibelli.
E masani ona faia se biopsy ona e mafai ona foliga tutusa ma le actinic keratosis po'o le squamous cell carcinoma.