Toxic epidermal necrosis
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O le ā le uiga o le Toxic epidermal necrosis?
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ReferencesStevens-Johnson Syndrome (SJS) ma Toxic Epidermal Necrolysis (TEN) o ni tulaga e seasea ona maua le pa'u o le necrosis tele ma le maligi. I le tulaga o togafitiga, o le cyclosporine e sili ona aoga mo le SJS, ae o le tuʻufaʻatasiga o le immunoglobulin intravenous (IVIg) ma corticosteroids e sili ona aoga mo mataupu o le SJS ma le TEN.
Stevens-Johnson Syndrome (SJS) and Toxic Epidermal Necrolysis (TEN) are rare diseases that are characterized by widespread epidermal necrosis and sloughing of skin. Regarding treatment, cyclosporine is the most effective therapy for the treatment of SJS, and a combination of intravenous immunoglobulin (IVIg) and corticosteroids is most effective for SJS/TEN overlap and TEN.
Stevens-Johnson Syndrome (SJS) and Toxic Epidermal Necrolysis (TEN) are rare diseases that are characterized by widespread epidermal necrosis and sloughing of skin. Regarding treatment, cyclosporine is the most effective therapy for the treatment of SJS, and a combination of intravenous immunoglobulin (IVIg) and corticosteroids is most effective for SJS/TEN overlap and TEN.
Toxic epidermal necrolysis (TEN) o se fa'alavelave tuga o le pa'u e mafua mai i vaila'au fa'apitoa ma fa'agaoioiga o le puipuiga o le tino, e i'u ai i le fa'ateteleina o le pa'u pito i fafo (epidermis), e a'afia ai le sili atu i le 30% o le tino. O le TEN e sili atu i le 20% le aofa'i o tagata maliliu, e masani lava ona o ma'i pipisi ma faigata ona manava. O le taofi o vaila'au e mafua ai le fa'alavelave, tuʻuina atu o le tausiga lagolago, ma le faʻaaogaina o togafitiga faa'opoopo e mafai ona fa'aleleia le taunuuga. Su'esu'ega talu ai nei ua fa'aalia ai o vaila'au e pei o le cyclosporine, tumor necrosis factor alpha inhibitors, ma le tu'ufa'atasia o le intravenous immune globulin ma corticosteroids e mafai ona fesoasoani, fa'avae i luga o fa'ata'ita'iga fa'atonutonu ma su'esu'ega o le tele o su'esu'ega.
Toxic epidermal necrolysis (TEN) is a serious skin reaction caused by certain medications and immune system activity, resulting in large-scale detachment of the outer skin layer (epidermis), affecting more than 30% of the body's surface. TEN has a mortality rate of over 20%, often due to infections and breathing difficulties. Stopping the medication causing the reaction, providing supportive care, and using additional treatments can improve the outcome. Recent studies have shown that drugs like cyclosporine, tumor necrosis factor alpha inhibitors, and a combination of intravenous immune globulin and corticosteroids can be helpful, based on randomized controlled trials and analyses of multiple studies.
Toxic epidermal necrolysis (TEN) is a serious skin reaction caused by certain medications and immune system activity, resulting in large-scale detachment of the outer skin layer (epidermis), affecting more than 30% of the body's surface. TEN has a mortality rate of over 20%, often due to infections and breathing difficulties. Stopping the medication causing the reaction, providing supportive care, and using additional treatments can improve the outcome. Recent studies have shown that drugs like cyclosporine, tumor necrosis factor alpha inhibitors, and a combination of intravenous immune globulin and corticosteroids can be helpful, based on randomized controlled trials and analyses of multiple studies.
Recent Advances: There is improved understanding of pain and morbidity with regard to the type and frequency of dressing changes. More modern dressings, such as nanocrystalline, are currently favored as they may be kept in situ for longer periods. The most recent evidence on systemic agents, such as corticosteroids and cyclosporine, and novel treatments, are also discussed.
Ole mafua'aga sili ona masani o vaila'au fa'apitoa e pei o le lamotrigine, carbamazepine, allopurinol, sulfonamide antibiotic, ma nevirapine. O a'afiaga e aofia ai le HIV ma le systemic lupus erythematosus. Togafitiga e masani lava ona faia i le falema'i e pei o le vaega mu po'o le potu mo gasegase tigaina.
○ Togafiti
O se fa'ama'i tuga lea, afai e a'afia lou laugutu po'o lou gutu po'o le pa'u, va'ai i lau foma'i i se taimi vave.
O vaila'au masalo e tatau ona fa'agata (e.g., antibiotics, non‑steroidal anti‑inflammatory drugs).