Herpes zoster
https://en.wikipedia.org/wiki/Shingles
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References
Herpes Zoster and Postherpetic Neuralgia: Prevention and Management 29431387Shingles, inokonzerwa nekudzokorodza kwevaricella‑zoster virus (inokonzera chickenpox), inobata vanhu vanosvika mamiriyoni imwe pagore muUnited States, uye inopa ngozi yehupenyu inosvika 30%. Vanhu vane immune system isina simba ndivo vanonyanya kukurumidza kuwana shingles. Zviratidzo zvinowanzotanga nekunzwa kusagadzikana (malaise), kutemwa nemusoro, uye fivha yakapfava, izvo zvinoteverwa nekusajairika kwekunzwa kweganda kwemazuva mashoma vasati vaona mavanga. Kuputika uku, kunowanzoonekwa munzvimbo chaiyo yemuviri, kunotanga neblister dzakajeka dzichizova maronda akaoma mukati memavhiki gumi. Kurapwa nekukurumidza nemishonga inorwisa mavhairasi (acyclovir, valacyclovir, kana famciclovir) mukati memaawa 72 ekutanga kwepundu kwakakosha. Postherpetic neuralgia, dambudziko rinowanzozivikanwa nekurwadziwa kwenguva refu munzvimbo yakakanganiswa, rinobata anenge mumwe wevarwere vashanu. Rinodawo kurapwa kunoramba kuchienderera mberi nemishonga yakadai se gabapentin, pregabalin, kana mamwe maantidepressants, pamwe nemishonga inonzi lidocaine kana capsaicin. Kudzivirira varicella‑zoster virus kunokurudzirwa kuvanhu vakuru vane makore makumi mashanu zvichikwira, kuitira kuderedza njodzi ye shingles.
Shingles, caused by the reactivation of the varicella zoster virus responsible for chickenpox, affects around 1 million people annually in the United States, with a lifetime risk of 30%. Those with weakened immune systems are significantly more prone to developing shingles, with symptoms typically starting with malaise, headache, and a mild fever, followed by unusual skin sensations a few days before the appearance of a rash. This rash, usually appearing in a specific area of the body, progresses from clear blisters to crusted sores over a week to ten days. Prompt treatment with antiviral medications (acyclovir, valacyclovir, or famciclovir) within 72 hours of rash onset is crucial. Postherpetic neuralgia, a common complication characterized by prolonged pain in the affected area, affects about one in five patients and requires ongoing management with medications such as gabapentin, pregabalin, or certain antidepressants, along with topical agents like lidocaine or capsaicin. Vaccination against the varicella zoster virus is recommended for adults aged 50 and above to reduce the risk of shingles.
Epidemiology, treatment and prevention of herpes zoster: A comprehensive review 29516900Herpes zoster inowanzoitika muvanhu vane makore makumi mashanu zvichikwira, avo vane immune system isina simba, uye avo vanotora mishonga yeimmunosuppressant. Inokonzerwa nekuvandudzwa kwehutachiona hwevaricella‑zoster, hutachiona hunokonzera chickenpox. Zviratidzo zvakaita sefivha, kurwadziwa, uye kukwenya zvinowanzotanga pakuratidza chimiro chepundu. Dambudziko rinowanzoitika ndere post‑herpetic neuralgia, iro rinoramba richirwadza tsinga mushure mekuputika kwapera. Zvinokonzeresa uye zvinonetsa zvine chekuita neherpes zoster zvinosiyana zvichienderana nezera, hutano hweimmune system, uye nguva yekutanga kurapwa. Kudzivirira kune vanhu vane makore makumi matanhatu zvichikwira kwakaratidza kuderedza zvakanyanya kuwanikwa kweherpes zoster uye post‑herpetic neuralgia. Kutanga mishonga inorwisa mavhairasi uye inoderedza marwadzo mukati meawa 72 kunogona kuderedza kuomarara uye matambudziko eherpes zoster pamwe nepost‑herpetic neuralgia.
Herpes zoster tends to occur more frequently in people aged 50 and older, those with weakened immune systems, and those taking immunosuppressant medications. It's triggered by the reactivation of the varicella-zoster virus, the same virus that causes chickenpox. Symptoms like fever, pain, and itching commonly precede the appearance of the characteristic rash. The most common complication is post-herpetic neuralgia, which is persistent nerve pain after the rash clears up. The risk factors and complications associated with herpes zoster vary depending on age, immune health, and timing of treatment initiation. Vaccination for individuals aged 60 and above has been shown to significantly reduce the occurrence of herpes zoster and post-herpetic neuralgia. Starting antiviral medications and pain relievers within 72 hours of rash onset can lessen the severity and complications of herpes zoster and post-herpetic neuralgia.
Prevention of Herpes Zoster: A Focus on the Effectiveness and Safety of Herpes Zoster Vaccines 36560671 NIH
Miedzo yekiriniki isati yanyatsotenderwa inoratidza kuti jekiseni mhenyu yekudzivirira zoster inoshanda pakati pe50% ne70%, nepo recombinant vaccine ichishanda zvakanyanya, kubva pa90% kusvika 97%. Muzvidzidzo zvepasirese, data inotsigira izvi, ichiratidza kuti jekiseni mhenyu rinoshanda 46%, nepo recombinant ichishanda 85%.
The pre-licensure clinical trials show the efficacy of the live zoster vaccine to be between 50 and 70% and for the recombinant vaccine to be higher at 90 to 97%. Real-world effectiveness studies, with a follow-up of approximately 10 years, were reviewed in this article. These data corroborated the efficacy studies, with vaccine effectiveness being 46% and 85% for the live and recombinant vaccines, respectively.
Chickenpox, inonziwo varicella, inokonzerwa nehutachiona hwevaricella, hunowanzoitika panguva yehuduku kana kuyaruka. Kana chickenpox yapora, hutachiona hunogona kurara (hwakarara) mumasero etsinga dzevanhu kwemakore kana makumi emakore, uye mushure mezvo hunogona kumutsiridzwa. Herpes zoster inowanikwa kana virus yevaricella yakarara ikadzokorodza. Ipapo utachiona hunopinda mutsinga dzeganda, huchibudisa matuzu. Munguva yekuputika kwe herpes zoster, kuratidzwa kune varicella virus kunowanikwa mu herpes zoster blisters kunogona kukonzera chickenpox kumunhu asati aita chickenpox.
Zvikonzero zvekukonzeresa herpes zoster zvinosanganisira kuchembera, kusashanda zvakanaka kweimmune system, uye kubata chickenpox isati yasvika mwedzi gumi nemasere. Varicella zoster virus haina kufanana neherpes simplex virus, kunyangwe vese vari vemhuri imwechete yeherpesviruses.
Majekiseni eHerpes zoster anoderedza njodzi yekutapukirwa neherpes zoster ne50% kusvika 90%. Anoderedzawo mukana we postherpetic neuralgia, uye kana herpes zoster ikaitika, anoderedza kuoma kwayo. Kana herpes zoster yatanga, mishonga inorwisa mavhairasi yakadai seaciclovir inogona kuderedza kuoma uye nguva yechirwere kana yatanga mukati maawa makumi manomwe nemaviri ekutanga kwepundu.
○ Kurapa
Kana maronda ari kupararira nekukasira, ona chiremba wako nekukasira kuti uwane mushonga weantiviral.
Zvose zviri zviviri antiviral mishonga uye neuralgia mishonga zvinodiwa. Unofanira kuzorora uye kurega kunwa doro.
#Acyclovir
#Fancyclovir
#Valacyclovir
#Gabapentin
#Pregabalin