Neurofibromatosis type I (NF-1) is a complex multi-system human disorder caused by the mutation of a gene on chromosome 17 that is responsible for production of a protein, called neurofibromin, which is needed for normal function in many human cell types.
Neurofibromatosis is a condition inokonzera mapundi mutsanga dzetsinga neganda. Type 1 inogarwa nhaka zvakanyanya uye inoratidza zviratidzo se neurofibromas, café-au-lait spots, freckling, and optic gliomas. Kuongororwa kunobva pane zviratidzo zvekliniki. Type 2, kune rumwe rutivi, inomikwa ne bilateral vestibular schwannomas (VS) and meningiomas , zvakare yakagarwa nhaka zvakanyanya. Kutungamira kunosanganisira kugara uchitarisa uye kurapwa sezvinodiwa kune ese marudzi e neurofibromatosis. Neurofibromatosis is a neurocutaneous disorder characterized by tumors in the nervous system and skin. Neurofibromatosis types 1 and 2 are the most common and are distinct entities. Neurofibromatosis type 1, or von Recklinghausen disease, is an autosomal dominant disease. Neurofibromatosis type 1 presents with neurofibromas, cafe-au-lait macules, freckling, and optic gliomas. It is a clinical diagnosis. Neurofibromatosis type 2 (NF2) is a disease characterized by bilateral vestibular schwannomas (VS) and meningiomas. It has an autosomal dominant inheritance pattern. Treatment for neurofibromatosis types 1 and 2 is clinical monitoring and medical intervention when appropriate.
Zviratidzo zvinowanzoonekwa zve neurofibromatosis zvinosanganisira mavara matsvuku‑tsvuku muchikamu cheziso chinonzi Lisch nodules uye neurofibromas. Scoliosis (kukombama kwemusana), kurema kwekudzidza (learning difficulties), kusaona zvakanaka (visual problems), kurema kwepfungwa (intellectual disability), nzvimbo dzakawanda dze café au lait (café au lait spots) zvinogona kuperekedzwawo.
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