Neurofibromatosis type I (NF-1) is a complex multi-system human disorder caused by the mutation of a gene on chromosome 17 that is responsible for production of a protein, called neurofibromin, which is needed for normal function in many human cell types.
Neurofibromatosis is a condition inokonzera mapundu mutsinga dzetsinga neganda. Type 1 inogarwa nhaka zvakanyanya uye inoratidza zviratidzo se neurofibromas, café-au-lait spots, freckling, and optic gliomas. Kuongororwa kunobva pane zviratidzo zvekliniki. Type 2, kune rumwe rutivi, inomikwa ne bilateral vestibular schwannomas (VS) and meningiomas , zvakare yakagarwa nhaka zvakanyanya. Kutungamira kunosanganisira kugara uchitarisa uye kurapwa sezvinodiwa kune ese marudzi e neurofibromatosis. Neurofibromatosis is a neurocutaneous disorder characterized by tumors in the nervous system and skin. Neurofibromatosis types 1 and 2 are the most common and are distinct entities. Neurofibromatosis type 1, or von Recklinghausen disease, is an autosomal dominant disease. Neurofibromatosis type 1 presents with neurofibromas, cafe-au-lait macules, freckling, and optic gliomas. It is a clinical diagnosis. Neurofibromatosis type 2 (NF2) is a disease characterized by bilateral vestibular schwannomas (VS) and meningiomas. It has an autosomal dominant inheritance pattern. Treatment for neurofibromatosis types 1 and 2 is clinical monitoring and medical intervention when appropriate.
Zviratidzo zvinowanzoonekwa zve neurofibromatosis zvinosanganisira mavara matsvuku-tsvuku muchikamu cheziso chinonzi Lisch nodules uye neurofibromas. Scoliosis (kukombama kwemusana), kuremara kwekudzidza, kusaona zvakanaka, kuremara kwepfungwa, nzvimbo dzakawanda dzekofi kana pfari zvinogona kuperekedzwawo.
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