Porokeratosis
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Mune 2022 Stiftung Warentest mhedzisiro kubva kuGermany, kugutsikana kwevatengi neModelDerm kwakangodzikira zvishoma pane nekubhadharwa kwe telemedicine kubvunzana.
Mune 2022 Stiftung Warentest mhedzisiro kubva kuGermany, kugutsikana kwevatengi neModelDerm kwakangodzikira zvishoma pane nekubhadharwa kwe telemedicine kubvunzana.
Iwo mapendekete akaoma akabudikira ane hunhu.
relevance score : -100.0%
ReferencesPorokeratosis chiitiko cheganda chisingawanikwi chinoratidzwa nezvinetso zvekeratinization, zvichikonzera kukwidziridzwa, uye zvigamba zvakaita semhete kana mabumbu akakasharara paganda. Chinhu chacho chinotsanangurwa pasi pemicroscope nekuti kune cornoid lamella, kurongeka kwemasero ari pamusoro peganda. Porokeratosis inouya nenzira dzakasiyana siyana (disseminated superficial actinic porokeratosis, classical porokeratosis of Mibelli, porokeratosis palmaris plantaris et disseminatum, linear porokeratosis). Zvakakosha kuziva kuti porokeratosis inogona kuita gomarara reganda. Nzira yakanakisa yekuongorora porokeratosis ndeye biopsy yemuganho wakasimudzwa, kunyangwe parizvino hapana chiyero chekurapa.
Porokeratosis is an uncommon dermatologic disorder. It is a disorder of keratinization that presents with keratotic papules or annular plaques with an elevated border. It has a distinct histologic hallmark of cornoid lamella, which is a column of tightly fitted parakeratotic cells in the upper epidermis. There are multiple clinical variants of porokeratosis, including disseminated superficial actinic porokeratosis, classical porokeratosis of Mibelli, porokeratosis palmaris plantaris et disseminatum, and linear porokeratosis. Porokeratosis is a precancerous lesion that can undergo malignant transformation. Evaluation of porokeratosis is best with a biopsy of the elevated border. There are no standard guidelines for treatment.
Porokeratosis is an uncommon dermatologic disorder. It is a disorder of keratinization that presents with keratotic papules or annular plaques with an elevated border. It has a distinct histologic hallmark of cornoid lamella, which is a column of tightly fitted parakeratotic cells in the upper epidermis. There are multiple clinical variants of porokeratosis, including disseminated superficial actinic porokeratosis, classical porokeratosis of Mibelli, porokeratosis palmaris plantaris et disseminatum, and linear porokeratosis. Porokeratosis is a precancerous lesion that can undergo malignant transformation. Evaluation of porokeratosis is best with a biopsy of the elevated border. There are no standard guidelines for treatment.
Disseminated superficial actinic porokeratosis (DSAP) chirwere chekuvhiringidzika kwekeratinization. Ndiyo imwe yemhando nhanhatu dzeporokeratosis, uye inowanzobata nzvimbo dzakakura zvichienzaniswa nedzimwe (linear, Mibelli's, punctate, palmoplantar disseminated, superficial porokeratosis). Mhando inoputika yeporokeratosis inowanzobatana nekenza, kushaya simba kwekuzvidzivirira, kana kuzvimba. Zvinhu zvinokonzera njodzi zvinosanganisira genetics, kudzvanywa kwe immune system, uye kuratidzwa nezuva. DSAP inotanga semapundu epingi kana shava ane mipendero yakasimudzwa munzvimbo dzinowanikwa nezuva, dzimwe nguva zvichikonzera kuvaviwa kudiki. Mishonga inosiyana uye inogona kusanganisira topical creams, light therapy, kana mishonga yakaita se5-fluorouracil kana retinoids. Maronda aya anonzi precancerous, aine 7.5‑10% mukana wekushanduka kuita squamous cell carcinoma kana basal cell carcinoma.
Disseminated superficial actinic porokeratosis (DSAP) is a disease of disordered keratinization. Disseminated superficial actinic porokeratosis is one of six variants of porokeratosis. It has more extensive involvement than most other variants. These other variants include linear porokeratosis, porokeratosis of Mibelli, punctate porokeratosis, porokeratosis palmaris et plantaris disseminata, and disseminated superficial porokeratosis. The eruptive form of porokeratosis is associated with malignancy, immunosuppression, and a proinflammatory state. Risk factors for porokeratosis include genetics, immunosuppression, and ultraviolet light. The lesions in disseminated superficial actinic porokeratosis start as pink to brown papules and macules with a raised border in sun-exposed areas that can be asymptomatic or slightly pruritic. There are many options for the treatment of disseminated superficial actinic porokeratosis, including topical diclofenac, photodynamic therapy (PDT), 5-fluorouracil (5-FU), imiquimod, vitamin D analogs, retinoids, and lasers. These lesions are considered precancerous. There is a 7.5 to 10% risk of malignant transformation to squamous cell carcinoma or basal cell carcinoma.
Disseminated superficial actinic porokeratosis (DSAP) is a disease of disordered keratinization. Disseminated superficial actinic porokeratosis is one of six variants of porokeratosis. It has more extensive involvement than most other variants. These other variants include linear porokeratosis, porokeratosis of Mibelli, punctate porokeratosis, porokeratosis palmaris et plantaris disseminata, and disseminated superficial porokeratosis. The eruptive form of porokeratosis is associated with malignancy, immunosuppression, and a proinflammatory state. Risk factors for porokeratosis include genetics, immunosuppression, and ultraviolet light. The lesions in disseminated superficial actinic porokeratosis start as pink to brown papules and macules with a raised border in sun-exposed areas that can be asymptomatic or slightly pruritic. There are many options for the treatment of disseminated superficial actinic porokeratosis, including topical diclofenac, photodynamic therapy (PDT), 5-fluorouracil (5-FU), imiquimod, vitamin D analogs, retinoids, and lasers. These lesions are considered precancerous. There is a 7.5 to 10% risk of malignant transformation to squamous cell carcinoma or basal cell carcinoma.
Mumwe murume ane makore 52 ekuberekwa, aiva neutano hwakanaka, akauya aine chigamba chakaita sandara, chakaita serin’i pamucheto wechigunwe chechina, icho chakanga chavepo kwemakore maviri pasina kukonzera zviratidzo. Yakatanga diki, yakaoma, uye yakakura kunze nekufamba kwenguva. Kunyangwe kuedza kurapwa kwakasiyana senge cryotherapy, makirimu, antifungals, uye mishonga inorwisa mabhakitiriya, chigamba chacho hachina kuita nani. Kunyatsoiongorora nedermoscopy yakaratidza pakati pakaoma, dzvuku, nemuganhu wakakora, wakasimba. Chidimbu chidiki cheganda chakatorwa kubva kumucheto kwechigamba chakaratidza kukura kwesero rekunze mukati meganda, zvichisimbisa kuongororwa kwe porokeratosis of Mibelli.
A 52-year-old man with no past medical history presented with an asymptomatic annular atrophic patch on the distal portion of the fourth toe of 2 years’ duration. The lesion began as a small keratotic papule that gradually enlarged centrifugally. He had received multiple treatments including cryotherapy, topical corticosteroids, antifungals, and antibiotics without improvement. Dermoscopic examination revealed a scaly atrophic erythematous central area with a sharply demarcated peripheral hyperkeratotic structure. A skin biopsy of the edge of the lesion revealed a cornoid lamella with a column of parakeratotic cells extending from an invagination of the epidermis with absence of granular layer. The clinicopathologic correlation was consistent with porokeratosis of Mibelli.
A 52-year-old man with no past medical history presented with an asymptomatic annular atrophic patch on the distal portion of the fourth toe of 2 years’ duration. The lesion began as a small keratotic papule that gradually enlarged centrifugally. He had received multiple treatments including cryotherapy, topical corticosteroids, antifungals, and antibiotics without improvement. Dermoscopic examination revealed a scaly atrophic erythematous central area with a sharply demarcated peripheral hyperkeratotic structure. A skin biopsy of the edge of the lesion revealed a cornoid lamella with a column of parakeratotic cells extending from an invagination of the epidermis with absence of granular layer. The clinicopathologic correlation was consistent with porokeratosis of Mibelli.
Kazhinji biopsy inoitwa nekuti inogona kutaridzika yakafanana ne actinic keratosis kana squamous cell carcinoma.