Acute generalized exanthematous pustulosis
Acute generalized exanthematous pustulosis (AGEP) waa fal‑celin maqaarka ah oo naadir ah, taas oo 90% kiisaska ay la xiriirto isticmaalka daawooyinka. Acute generalized exanthematous pustulosis waxaa lagu gartaa dillaacyo maqaarka ah oo degdeg ah, kuwaas oo caadi ahaan soo baxa qiyaastii shan maalmood ka dib marka daawadu bilaabato. Dillaacyadaas waa malax, tusaale ahaan dillaac yar oo cad ama casaan ah oo maqaarka ah, oo ay ku jiraan walxo daruuro ama malax leh (malax). Nabarrada maqaarka waxay caadi ahaan bogsadaan 1–3 maalmood gudahood marka la joojiyo daawada keentay.
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Nabarro baahsan oo leh erythema iyo malax ayaa si lama filaan ah u soo baxay.
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ReferencesAcute generalized exanthematous pustulosis (AGEP) waa falcelin maqaarka ah oo lagu garto nabarro yaryar oo malax ka buuxo oo ku yaal salka maqaarka cas. Badanaa waxay dhacdaa marka qof qaato daawooyin qaarkood, sida antibiyootiga, kuwaas oo si dhakhso ah ugu fida jirka oo dhan. Ka dib marka la joojiyo daawada kicinta, calaamaduhu badanaa waxay ka baaba’aan laba toddobaad gudahood, inta badanna waxay ka tagaan maqaarka wax yar. In kasta oo badanaa aanay halis ahayn oo kaliya maqaarka ku kooban, xaaladaha daran waxaa la xiriiri karaa falcelin maqaarka oo halis ah sida Stevens-Johnson syndrome ama toxic epidermal necrolysis. Daaweynta ugu horreysa waa daryeel taageero ah, waxaana saadaasha guud ee cudurka badanaa aad u wanaagsan.
Acute generalized exanthematous pustulosis (AGEP) is an adverse cutaneous reaction characterized by sterile pinpoint nonfollicular pustules atop an erythematous background. Symptoms most often occur in the setting of medication exposure, such as systemic antibiotics, rapidly become generalized, followed by desquamation and resolution within about two weeks of discontinuing the offending trigger. Although mostly self-limited without systemic involvement, severe cases are classified alongside other cutaneous adverse reactions such as Stevens-Johnson syndrome, toxic epidermal necrolysis, and drug reaction with eosinophilia and systemic symptoms. Treatment is primarily supportive, and the prognosis for complete resolution is excellent.
Acute generalized exanthematous pustulosis (AGEP) is an adverse cutaneous reaction characterized by sterile pinpoint nonfollicular pustules atop an erythematous background. Symptoms most often occur in the setting of medication exposure, such as systemic antibiotics, rapidly become generalized, followed by desquamation and resolution within about two weeks of discontinuing the offending trigger. Although mostly self-limited without systemic involvement, severe cases are classified alongside other cutaneous adverse reactions such as Stevens-Johnson syndrome, toxic epidermal necrolysis, and drug reaction with eosinophilia and systemic symptoms. Treatment is primarily supportive, and the prognosis for complete resolution is excellent.
Recent experimental data reviewed herein are supportive of an early role of drug-induced innate immune activation and innate cytokines such as interleukin (IL)-1, IL-36, and IL-17 in the pathogenesis of AGEP. This explains the rapid onset and neutrophilic character of the cutaneous inflammation.
Nin 76 jir ah ayaa yimid qolka gargaarka degdegga ah sababtoo ah maqaarkiisu wuu isbedelay labadii maalmood ee la soo dhaafay. Dhakhaatiirtu waxay ka heleen meelo gaduudan jirkiisa iyo gacmaha iyo lugaha. Waqtigu markuu socday, balastarradan ayaa isku biiray, wuxuuna ku soo baxay kuuskuus u eg finan meelaha cas. Tijaabooyinku waxay muujiyeen tirada unugyada dhiiga cad oo sarreeya oo leh noocyo badan oo loo yaqaanno neutrophils, iyo korodhka heerarka C-reactive protein.
A 76-year-old male patient presented as an emergency due to a 2-day history of skin changes. Physical examination revealed disseminated erythematous macules and plaques on the trunk and extremities. In the further course, confluence of the macules and non-follicular pustulosis developed in the area of erythema. Laboratory tests revealed leukocytosis with neutrophils and elevated C-reactive protein.
A 76-year-old male patient presented as an emergency due to a 2-day history of skin changes. Physical examination revealed disseminated erythematous macules and plaques on the trunk and extremities. In the further course, confluence of the macules and non-follicular pustulosis developed in the area of erythema. Laboratory tests revealed leukocytosis with neutrophils and elevated C-reactive protein.
