Acute generalized exanthematous pustulosis
Acute generalized exanthematous pustulosis (AGEP) waa fal-celin maqaarka ah oo naadir ah taas oo 90% kiisaska ay la xiriirto maamulka dawada. Acute generalized exanthematous pustulosis waxa lagu gartaa dillaacyo maqaar oo degdeg ah oo soo baxa celcelis ahaan shan maalmood ka dib marka daawadu bilaabato. Dildilaacani waa malax, tusaale ahaan dillaac yar oo cad ama cas oo maqaarka ah oo ay ku jiraan walxo daruuro ama malax leh (malax). Nabarrada maqaarku waxay caadi ahaan ku xalliyaan 1-3 maalmood gudahooda marka la joojiyo dawada xadgudubka leh.
☆ Natiijooyinka Stiftung Warentest ee 2022 ee ka yimid Jarmalka, ku qanacsanaanta macaamilka ee ModelDerm ayaa waxyar uun ka hooseysay la-talinta telemedicine-ka ee lacagta lagu bixiyo.
Nabaro baahsan oo leh erythema iyo malax ayaa si lama filaan ah u soo baxay.
References
Acute generalized exanthematous pustulosis (AGEP) waa falcelin maqaarka ah oo lagu asteeyay nabarro yaryar oo malax ka buuxo oo ku yaal salka maqaarka cas. Badanaa waxay dhacdaa marka qof qaato daawooyinka qaarkood, sida antibiyootiga, oo si dhakhso ah ugu faafo jirka oo dhan. Ka dib marka la joojiyo daawada kicinta, calaamaduhu waxay caadi ahaan ku tagaan laba toddobaad gudahood, inta badan waxay ka tagaan maqaarka qaarkiis. In kasta oo inta badan aanay ahayn mid halis ah oo aan ku koobnayn maqaarka, xaaladaha daran waxaa lagu soo dari karaa dareen-celinta maqaarka kale ee halista ah sida Stevens-Johnson syndrome ama toxic epidermal necrolysis. Daawaynta ugu horrayn waa daryeel taageero ah, iyo saadaasha xallinta dhammaystiran ee cudurka badanaa waa mid aad u wanaagsan.
Acute generalized exanthematous pustulosis (AGEP) is an adverse cutaneous reaction characterized by sterile pinpoint nonfollicular pustules atop an erythematous background. Symptoms most often occur in the setting of medication exposure, such as systemic antibiotics, rapidly become generalized, followed by desquamation and resolution within about two weeks of discontinuing the offending trigger. Although mostly self-limited without systemic involvement, severe cases are classified alongside other cutaneous adverse reactions such as Stevens-Johnson syndrome, toxic epidermal necrolysis, and drug reaction with eosinophilia and systemic symptoms. Treatment is primarily supportive, and the prognosis for complete resolution is excellent.
Acute generalized exanthematous pustulosis (AGEP) is an adverse cutaneous reaction characterized by sterile pinpoint nonfollicular pustules atop an erythematous background. Symptoms most often occur in the setting of medication exposure, such as systemic antibiotics, rapidly become generalized, followed by desquamation and resolution within about two weeks of discontinuing the offending trigger. Although mostly self-limited without systemic involvement, severe cases are classified alongside other cutaneous adverse reactions such as Stevens-Johnson syndrome, toxic epidermal necrolysis, and drug reaction with eosinophilia and systemic symptoms. Treatment is primarily supportive, and the prognosis for complete resolution is excellent.
Recent experimental data reviewed herein are supportive of an early role of drug-induced innate immune activation and innate cytokines such as interleukin (IL)-1, IL-36, and IL-17 in the pathogenesis of AGEP. This explains the rapid onset and neutrophilic character of the cutaneous inflammation.
Nin 76 jir ah ayaa yimid qolka gargaarka degdegga ah sababtoo ah maqaarkiisu wuu isbedelay labadii maalmood ee la soo dhaafay. Dhakhaatiirtu waxay ka heleen meelo gaduudan jirkiisa iyo gacmaha iyo lugaha. Waqtigu markuu socday, balastarradan ayaa isku biiray, wuxuuna ku soo baxay kuuskuus u eg finan meelaha cas. Tijaabooyinku waxay muujiyeen tirada unugyada dhiiga cad oo sarreeya oo leh noocyo badan oo loo yaqaanno neutrophils, iyo korodhka heerarka C-reactive protein.
A 76-year-old male patient presented as an emergency due to a 2-day history of skin changes. Physical examination revealed disseminated erythematous macules and plaques on the trunk and extremities. In the further course, confluence of the macules and non-follicular pustulosis developed in the area of erythema. Laboratory tests revealed leukocytosis with neutrophils and elevated C-reactive protein.
A 76-year-old male patient presented as an emergency due to a 2-day history of skin changes. Physical examination revealed disseminated erythematous macules and plaques on the trunk and extremities. In the further course, confluence of the macules and non-follicular pustulosis developed in the area of erythema. Laboratory tests revealed leukocytosis with neutrophils and elevated C-reactive protein.
