Porokeratosis
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ReferencesPorokeratosis waa xaalad maqaarka ah oo naadir ah, oo lagu garto dhibaatooyinka keratinization, taasoo keenta kor u kaca, balastar-qaabeeya ama nabarro qallafsan oo maqaarka ah. Sifada lagu garto mikroskoobka waa joogitaanka cornoid lamella, oo ah habayn gaar ah oo unugyo ah oo ku jira lakabka sare ee maqaarka. Porokeratosis waxay ku timaadaa qaabab kala duwan (disseminated superficial actinic porokeratosis, classical porokeratosis of Mibelli, porokeratosis palmaris plantaris et disseminatum, linear porokeratosis). Waa muhiim in la ogaado in porokeratosis uu kordhin karo khatarta kansarka maqaarka. Habka ugu fiican ee lagu ogaado porokeratosis waa biopsy laga qaado lakabka sare ee maqaarka, in kasta oo hadda aan jirin daaweyn caadi ah.
Porokeratosis is an uncommon dermatologic disorder. It is a disorder of keratinization that presents with keratotic papules or annular plaques with an elevated border. It has a distinct histologic hallmark of cornoid lamella, which is a column of tightly fitted parakeratotic cells in the upper epidermis. There are multiple clinical variants of porokeratosis, including disseminated superficial actinic porokeratosis, classical porokeratosis of Mibelli, porokeratosis palmaris plantaris et disseminatum, and linear porokeratosis. Porokeratosis is a precancerous lesion that can undergo malignant transformation. Evaluation of porokeratosis is best with a biopsy of the elevated border. There are no standard guidelines for treatment.
Porokeratosis is an uncommon dermatologic disorder. It is a disorder of keratinization that presents with keratotic papules or annular plaques with an elevated border. It has a distinct histologic hallmark of cornoid lamella, which is a column of tightly fitted parakeratotic cells in the upper epidermis. There are multiple clinical variants of porokeratosis, including disseminated superficial actinic porokeratosis, classical porokeratosis of Mibelli, porokeratosis palmaris plantaris et disseminatum, and linear porokeratosis. Porokeratosis is a precancerous lesion that can undergo malignant transformation. Evaluation of porokeratosis is best with a biopsy of the elevated border. There are no standard guidelines for treatment.
Disseminated superficial actinic porokeratosis (DSAP) waa cudur keratinization ah oo khalkhal ah. Waa mid ka mid ah lix nooc oo porokeratosis ah, waxayna caadi ahaan saameeyaa meelaha waaweyn marka loo eego kuwa kale (linear, Mibelli's, punctate, palmoplantar disseminated, superficial porokeratosis). Nooca dilaaca ee porokeratosis badanaa wuxuu la xiriiraa kansar, difaac daciif ah, ama barar. Qodobbada khatarta ah waxaa ka mid ah hidde-sideyaasha, xakamaynta difaaca, iyo soo-gaadhista qorraxda. DSAP waxay ku bilaabataa sidii barar casaan ama bunni ah oo leh cidhifyo kor u kaca oo ku yaal meelaha qorraxdu soo bandhigto, mararka qaarna waxay keentaa cuncun yar. Daaweyntu way kala duwan tahay, waxaana ku jiri kara kiriimyada la mariyo, daawaynta iftiinka, ama daawooyinka sida 5-fluorouracil ama retinoids. Nabarradan waxaa loo tixgaliyaa inay yihiin kuwo hore‑kansar ah, iyadoo 7.5–10 % fursad ay u leeyihiin inay isu beddelaan unugyada squamous‑ka ama kansarka unugyada basal‑ka.
Disseminated superficial actinic porokeratosis (DSAP) is a disease of disordered keratinization. Disseminated superficial actinic porokeratosis is one of six variants of porokeratosis. It has more extensive involvement than most other variants. These other variants include linear porokeratosis, porokeratosis of Mibelli, punctate porokeratosis, porokeratosis palmaris et plantaris disseminata, and disseminated superficial porokeratosis. The eruptive form of porokeratosis is associated with malignancy, immunosuppression, and a proinflammatory state. Risk factors for porokeratosis include genetics, immunosuppression, and ultraviolet light. The lesions in disseminated superficial actinic porokeratosis start as pink to brown papules and macules with a raised border in sun-exposed areas that can be asymptomatic or slightly pruritic. There are many options for the treatment of disseminated superficial actinic porokeratosis, including topical diclofenac, photodynamic therapy (PDT), 5-fluorouracil (5-FU), imiquimod, vitamin D analogs, retinoids, and lasers. These lesions are considered precancerous. There is a 7.5 to 10% risk of malignant transformation to squamous cell carcinoma or basal cell carcinoma.
Disseminated superficial actinic porokeratosis (DSAP) is a disease of disordered keratinization. Disseminated superficial actinic porokeratosis is one of six variants of porokeratosis. It has more extensive involvement than most other variants. These other variants include linear porokeratosis, porokeratosis of Mibelli, punctate porokeratosis, porokeratosis palmaris et plantaris disseminata, and disseminated superficial porokeratosis. The eruptive form of porokeratosis is associated with malignancy, immunosuppression, and a proinflammatory state. Risk factors for porokeratosis include genetics, immunosuppression, and ultraviolet light. The lesions in disseminated superficial actinic porokeratosis start as pink to brown papules and macules with a raised border in sun-exposed areas that can be asymptomatic or slightly pruritic. There are many options for the treatment of disseminated superficial actinic porokeratosis, including topical diclofenac, photodynamic therapy (PDT), 5-fluorouracil (5-FU), imiquimod, vitamin D analogs, retinoids, and lasers. These lesions are considered precancerous. There is a 7.5 to 10% risk of malignant transformation to squamous cell carcinoma or basal cell carcinoma.
Nin 52 jir ah, oo markii hore caafimaad qabay, ayaa la soo ogaaday meel fidsan oo qaab giraanti ah oo ku taal cidhifka suulkiisa afraad, kaas oo muddo 2 sano ah halkaas ku jiray, isaga oo aan wax calaamado ah yeelan. Waxay ku bilaabatay sidii yar yar, barar adag, waxayna kortay dibadda waqti ka dib. In kasta oo la isku dayay daawooyin kala duwan sida cryotherapy, creams, antifungals, iyo antibiotics, balastarku ma roonayn. Marka si dhow loo baadho, dermoscopy waxay muujisay xarun qallalan, cas oo leh xudduud dhumuc leh oo qallafsan. Maqaar yar oo laga soo qaaday cidhifka balastarka wuxuu muujiyay korriinka unugyada aan caadiga ahayn ee lakabka sare ee maqaarka, taasoo xaqiijinaysa ogaanshaha porokeratosis of Mibelli.
A 52-year-old man with no past medical history presented with an asymptomatic annular atrophic patch on the distal portion of the fourth toe of 2 years’ duration. The lesion began as a small keratotic papule that gradually enlarged centrifugally. He had received multiple treatments including cryotherapy, topical corticosteroids, antifungals, and antibiotics without improvement. Dermoscopic examination revealed a scaly atrophic erythematous central area with a sharply demarcated peripheral hyperkeratotic structure. A skin biopsy of the edge of the lesion revealed a cornoid lamella with a column of parakeratotic cells extending from an invagination of the epidermis with absence of granular layer. The clinicopathologic correlation was consistent with porokeratosis of Mibelli.
A 52-year-old man with no past medical history presented with an asymptomatic annular atrophic patch on the distal portion of the fourth toe of 2 years’ duration. The lesion began as a small keratotic papule that gradually enlarged centrifugally. He had received multiple treatments including cryotherapy, topical corticosteroids, antifungals, and antibiotics without improvement. Dermoscopic examination revealed a scaly atrophic erythematous central area with a sharply demarcated peripheral hyperkeratotic structure. A skin biopsy of the edge of the lesion revealed a cornoid lamella with a column of parakeratotic cells extending from an invagination of the epidermis with absence of granular layer. The clinicopathologic correlation was consistent with porokeratosis of Mibelli.
Inta badan, ka-qaadis ayaa la sameeyaa sababtoo ah waxay u ekaan kartaa keratosis actinic ama kansarka unugyada squamous.