Livedoid vasculitis - Vaskuliti Livedoid
Vaskuliti Livedoid (Livedoid vasculitis) është një sëmundje kronike e lëkurës që shihet kryesisht tek gratë e reja deri në moshën e mesme. Një akronim i përdorur për të përshkruar tiparet e tij është "Ulçera purpurike të dhimbshme me model retikular të ekstremiteteve të poshtme" (PURPLE). Ajo shoqërohet me një sërë sëmundjesh, duke përfshirë hipertensionin venoz kronik dhe varikozitetet.
☆ Në rezultatet e Stiftung Warentest 2022 nga Gjermania, kënaqësia e konsumatorit me ModelDerm ishte vetëm pak më e ulët se sa me konsultimet e paguara të telemjekësisë.
Mund të shoqërohet me dhimbje.
References
Livedoid vasculopathy është një gjendje e rrallë e lëkurës e karakterizuar nga ulçera të dhimbshme që vazhdojnë të kthehen në pjesën e poshtme të këmbëve.
Livedoid vasculopathy (LV) is a rare thrombotic vasculopathy of the dermis characterized by painful, relapsing ulcers over the lower extremities. Diagnosis is challenging due to the overlap in clinical appearance and nomenclature with other skin disorders. Treatment selection is complicated by poor understanding of the pathogenesis of LV and lack of robust clinical trials evaluating therapy efficacy. The terminology and pathophysiology of LV are reviewed here, along with its epidemiology, clinical and histologic features, and treatment options. A diagnostic pathway is suggested to guide providers in evaluating for comorbidities, referring to appropriate specialists, and choosing from the available classes of therapy.
Livedoid vasculopathy (LV) is a rare thrombotic vasculopathy of the dermis characterized by painful, relapsing ulcers over the lower extremities. Diagnosis is challenging due to the overlap in clinical appearance and nomenclature with other skin disorders. Treatment selection is complicated by poor understanding of the pathogenesis of LV and lack of robust clinical trials evaluating therapy efficacy. The terminology and pathophysiology of LV are reviewed here, along with its epidemiology, clinical and histologic features, and treatment options. A diagnostic pathway is suggested to guide providers in evaluating for comorbidities, referring to appropriate specialists, and choosing from the available classes of therapy.
Livedoid vasculopathy është një gjendje e rrallë e lëkurës që shkakton ulçera të përsëritura në pjesën e poshtme të këmbëve, duke lënë pas plagët e zbehta të njohura si atrofi blanche. Ndërsa shkaku i saktë është ende i paqartë, besohet se rritja e koagulimit të gjakut (hypercoagulability) është faktori kryesor, me inflamacionin që luan një rol dytësor. Faktorët që kontribuojnë në mpiksjen përfshijnë si më poshtë - deficiencies in proteins C and S, genetic mutations like factor V Leiden, antithrombin III deficiency, prothrombin gene mutations, high levels of homocysteine. Në biopsi, gjendja tregon mpiksje gjaku brenda enëve, trashje të mureve të enëve dhe dhëmbëza. Trajtimi përfshin një qasje të shumëanshme që fokusohet në parandalimin e mpiksjes së gjakut me medikamente si ilaçet kundër trombociteve, holluesit e gjakut dhe terapia fibrinolitike. Për këtë gjendje të lëkurës mund të përdoren barna të ndryshme - colchicine and hydroxychloroquine, vasodilators, immunosuppressants.
Livedoid vasculopathy is a rare skin condition that causes recurring ulcers on the lower legs, leaving behind pale scars known as atrophie blanche. While the exact cause is still unclear, it's believed that increased blood clotting (hypercoagulability) is the main factor, with inflammation playing a secondary role. Factors contributing to clotting include as follows - deficiencies in proteins C and S, genetic mutations like factor V Leiden, antithrombin III deficiency, prothrombin gene mutations, high levels of homocysteine. In biopsies, the condition shows blood clots inside vessels, thickening of vessel walls, and scarring. Treatment involves a multi-pronged approach focusing on preventing blood clots with medications like anti-platelet drugs, blood thinners, and fibrinolytic therapy. Various drugs can be used for this skin condition - colchicine and hydroxychloroquine, vasodilators, immunosuppressants.
Livedoid vasculopathy is a rare skin condition that causes recurring ulcers on the lower legs, leaving behind pale scars known as atrophie blanche. While the exact cause is still unclear, it's believed that increased blood clotting (hypercoagulability) is the main factor, with inflammation playing a secondary role. Factors contributing to clotting include as follows - deficiencies in proteins C and S, genetic mutations like factor V Leiden, antithrombin III deficiency, prothrombin gene mutations, high levels of homocysteine. In biopsies, the condition shows blood clots inside vessels, thickening of vessel walls, and scarring. Treatment involves a multi-pronged approach focusing on preventing blood clots with medications like anti-platelet drugs, blood thinners, and fibrinolytic therapy. Various drugs can be used for this skin condition - colchicine and hydroxychloroquine, vasodilators, immunosuppressants.
Livedoid vasculopathy është një gjendje e rrallë ku lezione shfaqen në të dy këmbët. Formimi i mpiksjes së gjakut në enët e vogla të gjakut mendohet të shkaktohet nga rritja e mpiksjes dhe zvogëlimi i zbërthimit të mpiksjes, së bashku me dëmtimin e rreshtimit të enëve të gjakut. Është më e zakonshme tek femrat, veçanërisht midis moshës 15 dhe 50 vjeç. Lënia e duhanit, kujdesi për plagët dhe përdorimi i medikamenteve si holluesit e gjakut dhe ilaçet kundër trombociteve kanë qenë efektive.
Livedoid vasculopathy is a rare vasculopathy that is typically characterized by bilateral lower limb lesions. Increased thrombotic activity and decreased fibrinolytic activity along with endothelial damage are believed to be the cause of thrombus formation in the capillary vasculature. It is 3 times more common in females than in males, especially in patients between the ages of 15 to 50 years. There is no definite first-line treatment, but general measures like smoking cessation, wound care, and pharmacological measures like anticoagulants and antiplatelets have shown good results.
Livedoid vasculopathy is a rare vasculopathy that is typically characterized by bilateral lower limb lesions. Increased thrombotic activity and decreased fibrinolytic activity along with endothelial damage are believed to be the cause of thrombus formation in the capillary vasculature. It is 3 times more common in females than in males, especially in patients between the ages of 15 to 50 years. There is no definite first-line treatment, but general measures like smoking cessation, wound care, and pharmacological measures like anticoagulants and antiplatelets have shown good results.
