Squamous cell carcinoma - Karcinoma E Qelizave Skuamoze
☆ Në rezultatet e Stiftung Warentest 2022 nga Gjermania, kënaqësia e konsumatorit me ModelDerm ishte vetëm pak më e ulët se sa me konsultimet e paguara të telemjekësisë.
Squamous cell carcinoma well differentiated ― Vërehet një keratozë aktinike fqinje.
References
Squamous cell carcinoma (SCC) është kanceri i dytë më i zakonshëm i lëkurës në Shtetet e Bashkuara, pas basal cell carcinoma. Zakonisht fillon nga lezione prekanceroze të quajtura actinic keratosis dhe mund të përhapet në pjesë të tjera të trupit. Shkaku kryesor është ekspozimi ndaj rrezatimit ultravjollcë (UV) nga dielli, i cili grumbullohet me kalimin e kohës. Trajtimi zakonisht përfshin heqjen kirurgjikale, veçanërisht për SCC në kokë dhe qafë. Terapia me rrezatim është një opsion për pacientët e moshuar ose ata që nuk mund të bëjnë operacion. Imunosupresioni rrit rrezikun e SCC. Edhe pse rrallë, SCC mund të përhapet, veçanërisht në pacientët me sistem imunitar të dobësuar. Kontrollet e rregullta dhe mbrojtja nga dielli janë të rëndësishme për ata me SCC.
Squamous cell carcinoma of the skin or cutaneous squamous cell carcinoma is the second most common form of skin cancer in the United States, behind basal cell carcinoma. Squamous cell carcinoma has precursor lesions called actinic keratosis, exhibits tumor progression and has the potential to metastasize in the body. Ultraviolet (UV) solar radiation is the primary risk factor in the development of cutaneous squamous cell carcinoma and the cumulative exposure received over a lifetime plays a major part in the development of this cancer. Surgical excision is the primary treatment modality for cutaneous squamous cell carcinoma, with Mohs micrographic surgery being the preferred excisional technique for squamous cell carcinoma of the head and neck, and in other areas of high risk or squamous cell carcinoma with high-risk characteristics. Radiation therapy is reserved for squamous cell carcinoma in older patients or those who will not tolerate surgery, or when it has not been possible to obtain clear margins surgically. Adjuvant radiotherapy is commonly after surgical treatment in very high tumors. Immunosuppression significantly increases the risk of squamous cell carcinoma over the course of an individual’s life. Metastasis is uncommon for squamous cell carcinomas arising in areas of chronic sun exposure, but it can take place, and the risk is increased in immunosuppressed patients. Patients with cutaneous squamous cell carcinoma should be examined regularly and remember to use measures to protect from UV damage.
Squamous cell carcinoma of the skin or cutaneous squamous cell carcinoma is the second most common form of skin cancer in the United States, behind basal cell carcinoma. Squamous cell carcinoma has precursor lesions called actinic keratosis, exhibits tumor progression and has the potential to metastasize in the body. Ultraviolet (UV) solar radiation is the primary risk factor in the development of cutaneous squamous cell carcinoma and the cumulative exposure received over a lifetime plays a major part in the development of this cancer. Surgical excision is the primary treatment modality for cutaneous squamous cell carcinoma, with Mohs micrographic surgery being the preferred excisional technique for squamous cell carcinoma of the head and neck, and in other areas of high risk or squamous cell carcinoma with high-risk characteristics. Radiation therapy is reserved for squamous cell carcinoma in older patients or those who will not tolerate surgery, or when it has not been possible to obtain clear margins surgically. Adjuvant radiotherapy is commonly after surgical treatment in very high tumors. Immunosuppression significantly increases the risk of squamous cell carcinoma over the course of an individual’s life. Metastasis is uncommon for squamous cell carcinomas arising in areas of chronic sun exposure, but it can take place, and the risk is increased in immunosuppressed patients. Patients with cutaneous squamous cell carcinoma should be examined regularly and remember to use measures to protect from UV damage.
Cutaneous squamous cell carcinoma (CSCC) është kanceri i dytë më i zakonshëm tek njerëzit dhe numri i tij po rritet. Megjithëse CSCC zakonisht shfaq një sjellje klinike beninje, ajo mund të përhapet si në nivel lokal ashtu edhe në pjesë të tjera të trupit. Shkencëtarët kanë identifikuar rrugë specifike të përfshira në zhvillimin e CSCC, duke çuar në trajtime të reja. Numri i lartë i mutacioneve dhe rritja e rrezikut te pacientët me imunosupresion kanë nxitur zhvillimin e imunoterapisë. Ky përmbledhje shikon rrënjët gjenetike të CSCC dhe trajtimet më të fundit që synojnë molekula specifike dhe sistemin imunitar.
Cutaneous squamous cell carcinoma (CSCC) is the second most frequent cancer in humans and its incidence continues to rise. Although CSCC usually display a benign clinical behavior, it can be both locally invasive and metastatic. The signaling pathways involved in CSCC development have given rise to targetable molecules in recent decades. In addition, the high mutational burden and increased risk of CSCC in patients under immunosuppression were part of the rationale for developing the immunotherapy for CSCC that has changed the therapeutic landscape. This review focuses on the molecular basis of CSCC and the current biology-based approaches of targeted therapies and immune checkpoint inhibitors
Cutaneous squamous cell carcinoma (CSCC) is the second most frequent cancer in humans and its incidence continues to rise. Although CSCC usually display a benign clinical behavior, it can be both locally invasive and metastatic. The signaling pathways involved in CSCC development have given rise to targetable molecules in recent decades. In addition, the high mutational burden and increased risk of CSCC in patients under immunosuppression were part of the rationale for developing the immunotherapy for CSCC that has changed the therapeutic landscape. This review focuses on the molecular basis of CSCC and the current biology-based approaches of targeted therapies and immune checkpoint inhibitors
○ Diagnoza dhe trajtimi
#Dermoscopy
#Skin biopsy