Panniculitis - Панницулитис
☆ У резултатима Стифтунг Варентест-а за 2022. из Немачке, задовољство потрошача МоделДерм-ом је само нешто ниже него са плаћеним телемедицинским консултацијама.
Туберкулоза је један од значајних узрока.
References
Erythema nodosum is the most common form of panniculitis and is characterized by tender erythematous nodules mainly in the lower limbs on the pretibial area. The exact cause of erythema nodosum is unknown, although it appears to be a hypersensitivity response to a variety of antigenic stimuli. Although the etiology is mostly idiopathic, ruling out an underlying disease is imperative before diagnosing primary erythema nodosum. Erythema nodosum can be the first sign of a systemic disease that is triggered by a large group of processes, such as infections, inflammatory diseases, neoplasia, and/or drugs. The most common identifiable causes are streptococcal infections, primary tuberculosis, sarcoidosis, Behçet disease, inflammatory bowel disease, drugs, and pregnancy.
Panniculitis чине хетерогену групу инфламаторних болести које укључују поткожно масно ткиво. Ови поремећаји су ретки код деце. Паникулитис може бити примарни процес у системском поремећају или секундарни процес који је резултат инфекције, трауме или излагања лековима. Већина типова паникулитиса има исту клиничку слику (без обзира на етиологију) , са осетљивим, еритематозним поткожним чворовима.
Panniculitides form a heterogenous group of inflammatory diseases that involve the subcutaneous adipose tissue. These disorders are rare in children and have many aetiologies. As in adults, the panniculitis can be the primary process in a systemic disorder or a secondary process that results from infection, trauma or exposure to medication. Some types of panniculitis are seen more commonly or exclusively in children, and several new entities have been described in recent years. Most types of panniculitis have the same clinical presentation (regardless of the aetiology), with tender, erythematous subcutaneous nodules.
Panniculitides form a heterogenous group of inflammatory diseases that involve the subcutaneous adipose tissue. These disorders are rare in children and have many aetiologies. As in adults, the panniculitis can be the primary process in a systemic disorder or a secondary process that results from infection, trauma or exposure to medication. Some types of panniculitis are seen more commonly or exclusively in children, and several new entities have been described in recent years. Most types of panniculitis have the same clinical presentation (regardless of the aetiology), with tender, erythematous subcutaneous nodules.
Panniculitis , запаљење поткожног масног ткива, обично се манифестује инфламаторним чворовима. Erythema nodosum (EN) је клинички најчешћи облик паникулитиса. Док се до 55% ЕН сматра идиопатским, најчешћи узроци укључују инфекције, лекове, системске болести као што су саркоидоза и инфламаторна болест црева, трудноћа и малигнитет. ЕН се обично јавља у тинејџерима и 20-им годинама, а чешће се виђа код жена. Често му претходи неспецифични продром од једне до три недеље, који може укључивати грозницу, слабост и симптоме инфекције горњих дисајних путева. Затим следе кожне лезије, обично локализоване на екстензорном делу удова. Лезије су болни заобљени или овални, благо подигнути, неулцеративни црвени чворићи. Тачна патогенеза ЕН није схваћена, иако се сматра да је резултат таложења имуних комплекса у венулама септа у поткожној масти, што изазива неутрофилни паникулитис. Чак и без специфичне терапије за узрочно стање, ЕН се у већини случајева повлачи без лечења.
Panniculitis, inflammation of the subcutaneous fat, usually presents with inflammatory nodules. Erythema nodosum (EN) is clinically the most frequent form of panniculitis. Whilst up to 55% of EN is considered idiopathic, the most common causes include infections, drugs, systemic illnesses such as sarcoidosis and inflammatory bowel disease, pregnancy, and malignancy. EN typically presents in the teens and 20s, and is seen more commonly in females. It is often preceded by a non-specific prodrome of one to three weeks, which may include fever, malaise, and symptoms of an upper respiratory tract infection. Cutaneous lesions then follow, typically localized on the extensor aspect of the limbs. The lesions are painful rounded or oval, slightly raised, non-ulcerative red nodules. The exact pathogenesis of EN is not understood, although is thought to result from deposition of immune complexes in the venules of the septae in subcutaneous fat, causing a neutrophilic panniculitis. Even without specific therapy for a causative condition, EN resolves without treatment in most cases.
Panniculitis, inflammation of the subcutaneous fat, usually presents with inflammatory nodules. Erythema nodosum (EN) is clinically the most frequent form of panniculitis. Whilst up to 55% of EN is considered idiopathic, the most common causes include infections, drugs, systemic illnesses such as sarcoidosis and inflammatory bowel disease, pregnancy, and malignancy. EN typically presents in the teens and 20s, and is seen more commonly in females. It is often preceded by a non-specific prodrome of one to three weeks, which may include fever, malaise, and symptoms of an upper respiratory tract infection. Cutaneous lesions then follow, typically localized on the extensor aspect of the limbs. The lesions are painful rounded or oval, slightly raised, non-ulcerative red nodules. The exact pathogenesis of EN is not understood, although is thought to result from deposition of immune complexes in the venules of the septae in subcutaneous fat, causing a neutrophilic panniculitis. Even without specific therapy for a causative condition, EN resolves without treatment in most cases.
„Еритема нодозум“ је облик панницулитис (panniculitis) који карактеришу нежни црвени чворићи, 1–10 цм, повезани са системским симптомима укључујући грозницу, слабост и бол у зглобовима. Чворови се могу повући у периоду од 2-6 недеља без улцерација или ожиљака. Нодосум еритема је повезан са инфекцијама, укључујући хепатитис Ц, ЕБВ и туберкулозу, трудноћу, не-Ходгкинов лимфом и рак панкреаса.