Acute generalized exanthematous pustulosis - Pustulosis Exanthematous Umum Akut
Pustulosis Exanthematous Umum Akut (Acute generalized exanthematous pustulosis) (AGEP) mangrupikeun réaksi kulit anu jarang, anu dina 90 % kasus patali jeung administrasi obat. Pustulosis exanthematous umum akut (acute generalized exanthematous pustulosis) dicirikeun ku letusan kulit dadakan anu biasana muncul saatos kira‑kira lima poé ti mimiti nginum obat. Letusan ieu mangrupa pustula, nyaéta bintik leutik beureum bodas atawa beureum dina kulit anu ngandung eusi cairan mendung atawa purulen (nanah). Lesi kulit biasana réngsé dina 1‑3 dinten sanggeus ngeureunkeun obat nu nyababkeun.
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Lesi nyebar kalayan erythema sareng pustula muncul sacara tiba‑tiba.
relevance score : -100.0%
ReferencesAcute generalized exanthematous pustulosis (AGEP) nyaéta réaksi kulit anu ditandaan ku benjolan leutik nu pinuh ku nanah dina kulit beureum. Biasana kajadian sanggeus jalma nginum obat‑obatan tangtu, sapertos antibiotik, sarta gancang nyebar ka sakuliah awak. Sanggeus ngeureunkeun obat nu nyababkeun, gejala biasana leungit dina dua minggu, sering nyésakeun kulit. Sanajan biasana teu parah, kasus anu parah bisa diklasifikasikeun salaku réaksi kulit serius sapertos Stevens‑Johnson syndrome atawa toxic epidermal necrolysis. Pangobatan utama nyaéta perawatan suportif, jeung prognosis pikeun résolusi lengkep panyakit biasana saé.
Acute generalized exanthematous pustulosis (AGEP) is an adverse cutaneous reaction characterized by sterile pinpoint nonfollicular pustules atop an erythematous background. Symptoms most often occur in the setting of medication exposure, such as systemic antibiotics, rapidly become generalized, followed by desquamation and resolution within about two weeks of discontinuing the offending trigger. Although mostly self-limited without systemic involvement, severe cases are classified alongside other cutaneous adverse reactions such as Stevens-Johnson syndrome, toxic epidermal necrolysis, and drug reaction with eosinophilia and systemic symptoms. Treatment is primarily supportive, and the prognosis for complete resolution is excellent.
Acute generalized exanthematous pustulosis (AGEP) is an adverse cutaneous reaction characterized by sterile pinpoint nonfollicular pustules atop an erythematous background. Symptoms most often occur in the setting of medication exposure, such as systemic antibiotics, rapidly become generalized, followed by desquamation and resolution within about two weeks of discontinuing the offending trigger. Although mostly self-limited without systemic involvement, severe cases are classified alongside other cutaneous adverse reactions such as Stevens-Johnson syndrome, toxic epidermal necrolysis, and drug reaction with eosinophilia and systemic symptoms. Treatment is primarily supportive, and the prognosis for complete resolution is excellent.
Recent experimental data reviewed herein are supportive of an early role of drug-induced innate immune activation and innate cytokines such as interleukin (IL)-1, IL-36, and IL-17 in the pathogenesis of AGEP. This explains the rapid onset and neutrophilic character of the cutaneous inflammation.
Lalaki 76 taun sumping ka kamar darurat kusabab kulitna parantos robih dina dua dinten kapengker. Dokter mendakan bintik-bintik beureum sareng ngangkat daérah dina kalapa sareng panangan sareng sukuna. Salaku waktu nuluykeun, patches ieu ngagabung babarengan, sarta anjeunna ngembangkeun jarawat-kawas nabrak di wewengkon beureum. Tés nunjukkeun jumlah sél getih bodas anu luhur sareng seueur jinis anu disebut neutrofil, sareng tingkat paningkatan C-reactive protein.
A 76-year-old male patient presented as an emergency due to a 2-day history of skin changes. Physical examination revealed disseminated erythematous macules and plaques on the trunk and extremities. In the further course, confluence of the macules and non-follicular pustulosis developed in the area of erythema. Laboratory tests revealed leukocytosis with neutrophils and elevated C-reactive protein.
A 76-year-old male patient presented as an emergency due to a 2-day history of skin changes. Physical examination revealed disseminated erythematous macules and plaques on the trunk and extremities. In the further course, confluence of the macules and non-follicular pustulosis developed in the area of erythema. Laboratory tests revealed leukocytosis with neutrophils and elevated C-reactive protein.
