Dysplastic nevus - Nevus Dysplastic
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Dysplastic nevi ― Biopsi disarankeun pikeun urang Kulon.
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ReferencesNevus displastik (Dysplastic nevus), ogé katelah atipikal (atypical) atanapi nevus Clark (Clarks nevus), geus nyulut debat di dermatologi jeung dermatopatologi. Dokter mindeng ngalakukeun biopsi nevus ieu sabab bisa katingali abnormal jeung ngangkat masalah ngeunaan melanoma.
A dysplastic nevus is also referred to as an atypical or Clarks nevus and has been the topic of much debate in the fields of dermatology and dermatopathology. It is an acquired mole demonstrating a unique clinical and histopathologic appearance that sets it apart from the common nevus. These moles appear atypical clinically, often with a fried-egg appearance, and are commonly biopsied by providers due to the concern for melanoma.
A dysplastic nevus is also referred to as an atypical or Clarks nevus and has been the topic of much debate in the fields of dermatology and dermatopathology. It is an acquired mole demonstrating a unique clinical and histopathologic appearance that sets it apart from the common nevus. These moles appear atypical clinically, often with a fried-egg appearance, and are commonly biopsied by providers due to the concern for melanoma.
Dysplastic nevi, ogé katelah atypical atanapi Clark nevi, sakapeung bisa ngakibatkeun melanoma. Ngeunaan 36 % tina melanomas kapanggih deukeut dysplastic nevi. Tanda yén dysplastic nevi tiasa janten melanoma kalebet bentukna henteu rata, langkung seueur parobahan pigmén, atanapi warna abu-abu. Kanker ieu biasana lumangsung dina umur ngora (kira-kira pertengahan tilu puluhan), tiasa sababaraha kali, sareng sering aya dina batang. Sacara genetik, dysplastic nevi aya di antara benign nevi sareng melanoma. Tapi, ngan 20 % nepi ka 30 % melanoma asalna tina nevi nu geus aya. Kusabab sabagéan ageung nevi henteu janten melanoma, biasana henteu disarankeun pikeun ngaleungitkeunana sacara preventif.
Dysplastic nevus, also called atypical or Clark nevus, can be precursor to melanoma, as the observation that 36% of melanomas have dysplastic nevi near the invasive tumor supports. Signs that a dysplastic nevus may have transitioned into a melanoma include asymmetry in contour, a noticeable increase in pigment variations, or a grayish tint indicating regression. These malignancies typically arise at a younger age (mid-thirties), are sometimes multiple, and are often found on the trunk. Molecularly, dysplastic nevi have a profile intermediate between benign nevi and malignant melanoma. While there is a recognized connection between dysplastic nevi and melanoma, it’s crucial to note that only about 20% to 30% of melanomas evolve from preexisting nevi. Given that the majority of dysplastic and typical nevi do not develop into melanoma, preventive removal of melanocytic nevi is not typically advised.
Dysplastic nevus, also called atypical or Clark nevus, can be precursor to melanoma, as the observation that 36% of melanomas have dysplastic nevi near the invasive tumor supports. Signs that a dysplastic nevus may have transitioned into a melanoma include asymmetry in contour, a noticeable increase in pigment variations, or a grayish tint indicating regression. These malignancies typically arise at a younger age (mid-thirties), are sometimes multiple, and are often found on the trunk. Molecularly, dysplastic nevi have a profile intermediate between benign nevi and malignant melanoma. While there is a recognized connection between dysplastic nevi and melanoma, it’s crucial to note that only about 20% to 30% of melanomas evolve from preexisting nevi. Given that the majority of dysplastic and typical nevi do not develop into melanoma, preventive removal of melanocytic nevi is not typically advised.
Melanoma mangrupikeun jinis tumor anu kabentuk nalika melanosit, sél anu tanggung jawab warna kulit, janten kanker. Melanosit (melanocyte) asalna tina neural crest. Ieu ngandung harti yén melanoma bisa ngamekarkeun teu ukur dina kulit tapi ogé di wewengkon séjén dimana sél neural crest migrasi, kawas saluran cerna jeung uteuk. Laju kasalametan pikeun penderita melanoma tahap awal (tahap 0) luhur dina 97 %, sedengkeun turun sacara signifikan sakitar 10 % pikeun jalma anu didiagnosis kaserang panyakit tahap lanjut (tahap IV).
A melanoma is a tumor produced by the malignant transformation of melanocytes. Melanocytes are derived from the neural crest; consequently, melanomas, although they usually occur on the skin, can arise in other locations where neural crest cells migrate, such as the gastrointestinal tract and brain. The five-year relative survival rate for patients with stage 0 melanoma is 97%, compared with about 10% for those with stage IV disease.
A melanoma is a tumor produced by the malignant transformation of melanocytes. Melanocytes are derived from the neural crest; consequently, melanomas, although they usually occur on the skin, can arise in other locations where neural crest cells migrate, such as the gastrointestinal tract and brain. The five-year relative survival rate for patients with stage 0 melanoma is 97%, compared with about 10% for those with stage IV disease.
○ Risiko Kanker
Sapertos anu katingali dina individu Kaukasia di Amérika Serikat, anu ngagaduhan dysplastic nevi gaduh résiko hirupna pikeun ngembangkeun melanoma langkung ageung ti 10 %. Di sisi anu sanés, jalma anu henteu ngagaduhan dysplastic nevus gaduh résiko ngembangkeun melanoma kirang ti 1 %.
○ Pencegahan pikeun individu kalawan dysplastic nevi
Ujian diri kulit biasana disarankeun pikeun nyegah melanoma (ku cara ngaidentipikasi nevi atipikal anu tiasa dipiceun) atanapi pikeun deteksi awal tumor anu aya. Jalma anu boga sajarah pribadi atawa kulawarga kanker kulit atawa sababaraha nevi atipikal kedah ningali dermatolog sahenteuna sataun sakali pikeun mastikeun aranjeunna teu ngamekarkeun melanoma.
Singketan [ABCDE] parantos kapaké pikeun ngabantosan panyadia kasehatan sareng jalma awam émut ciri‑ciri konci melanoma. Hanjakalna pikeun jalma rata‑rata, seueur keratoses seborrheic, sababaraha lentigo senilis, bahkan kutil tiasa gaduh ciri [ABCDE], sareng teu tiasa dibédakeun tina melanoma.
○ [ABCDE]
Asymmetrical: Lesi kulit asimétrik.
Border: Wates lesi henteu teratur.
Color: melanoma biasana mibanda sababaraha warna anu henteu teratur.
Diameter: nevi leuwih gede ti 6 mm leuwih gampang jadi melanoma ti nevi leutik.
Evolution: Évolusi (nyaéta parobahan) nevus atanapi lesi tiasa nunjukkeun yén lesi janten ganas.