Porokeratosis
☆ Dina hasil Stiftung Warentest 2022 ti Jerman, kapuasan konsumen sareng ModelDerm ngan ukur langkung handap tibatan konsultasi telemedicine anu mayar.
The hard protruding edges mangrupakeun ciri.
References
Porokeratosis mangrupakeun kaayaan kulit langka dicirikeun ku masalah keratinization, hasilna timbul, patch ngawangun cingcin atawa nabrak kasar dina kulit. Ciri anu ditetepkeun dina mikroskop nyaéta ayana lamella kornoid, susunan husus sél dina lapisan luhur kulit. Porokeratosis asalna dina rupa-rupa bentuk (disseminated superficial actinic porokeratosis, classical porokeratosis of Mibelli, porokeratosis palmaris plantaris et disseminatum, linear porokeratosis) . Penting pikeun dicatet yén porokeratosis tiasa berpotensi janten kanker kulit. Cara anu pangsaéna pikeun ngadiagnosis porokeratosis nyaéta ngaliwatan biopsi wates anu digedékeun, sanaos ayeuna teu aya protokol perawatan standar.
Porokeratosis is an uncommon dermatologic disorder. It is a disorder of keratinization that presents with keratotic papules or annular plaques with an elevated border. It has a distinct histologic hallmark of cornoid lamella, which is a column of tightly fitted parakeratotic cells in the upper epidermis. There are multiple clinical variants of porokeratosis, including disseminated superficial actinic porokeratosis, classical porokeratosis of Mibelli, porokeratosis palmaris plantaris et disseminatum, and linear porokeratosis. Porokeratosis is a precancerous lesion that can undergo malignant transformation. Evaluation of porokeratosis is best with a biopsy of the elevated border. There are no standard guidelines for treatment.
Porokeratosis is an uncommon dermatologic disorder. It is a disorder of keratinization that presents with keratotic papules or annular plaques with an elevated border. It has a distinct histologic hallmark of cornoid lamella, which is a column of tightly fitted parakeratotic cells in the upper epidermis. There are multiple clinical variants of porokeratosis, including disseminated superficial actinic porokeratosis, classical porokeratosis of Mibelli, porokeratosis palmaris plantaris et disseminatum, and linear porokeratosis. Porokeratosis is a precancerous lesion that can undergo malignant transformation. Evaluation of porokeratosis is best with a biopsy of the elevated border. There are no standard guidelines for treatment.
Disseminated superficial actinic porokeratosis (DSAP) mangrupikeun panyakit keratinisasi anu teu kaganggu. Ieu salah sahiji genep jenis porokeratosis, sarta ilaharna mangaruhan wewengkon nu leuwih gede dibandingkeun jeung lianna (linear, Mibelli's, punctate, palmoplantar disseminated, superficial porokeratosis) . Jinis eruptive tina porokeratosis mindeng numbu ka kanker, kekebalan lemah, atawa peradangan. Faktor résiko ngalibatkeun genetik, suprési imun, sareng paparan panonpoé. DSAP dimimitian salaku nabrak pink atawa coklat jeung ujung diangkat di wewengkon kakeunaan panonpoé, sakapeung ngabalukarkeun slight itching. Pangobatan rupa-rupa sareng tiasa kalebet krim topikal, terapi cahaya, atanapi pangobatan sapertos 5-fluorouracil atanapi retinoid. Lesi ieu dianggap precancerous, kalawan 7. 5 - 10 % kasempetan robah jadi sél squamous atawa carcinoma sél basal.
Disseminated superficial actinic porokeratosis (DSAP) is a disease of disordered keratinization. Disseminated superficial actinic porokeratosis is one of six variants of porokeratosis. It has more extensive involvement than most other variants. These other variants include linear porokeratosis, porokeratosis of Mibelli, punctate porokeratosis, porokeratosis palmaris et plantaris disseminata, and disseminated superficial porokeratosis. The eruptive form of porokeratosis is associated with malignancy, immunosuppression, and a proinflammatory state. Risk factors for porokeratosis include genetics, immunosuppression, and ultraviolet light. The lesions in disseminated superficial actinic porokeratosis start as pink to brown papules and macules with a raised border in sun-exposed areas that can be asymptomatic or slightly pruritic. There are many options for the treatment of disseminated superficial actinic porokeratosis, including topical diclofenac, photodynamic therapy (PDT), 5-fluorouracil (5-FU), imiquimod, vitamin D analogs, retinoids, and lasers. These lesions are considered precancerous. There is a 7.5 to 10% risk of malignant transformation to squamous cell carcinoma or basal cell carcinoma.
Disseminated superficial actinic porokeratosis (DSAP) is a disease of disordered keratinization. Disseminated superficial actinic porokeratosis is one of six variants of porokeratosis. It has more extensive involvement than most other variants. These other variants include linear porokeratosis, porokeratosis of Mibelli, punctate porokeratosis, porokeratosis palmaris et plantaris disseminata, and disseminated superficial porokeratosis. The eruptive form of porokeratosis is associated with malignancy, immunosuppression, and a proinflammatory state. Risk factors for porokeratosis include genetics, immunosuppression, and ultraviolet light. The lesions in disseminated superficial actinic porokeratosis start as pink to brown papules and macules with a raised border in sun-exposed areas that can be asymptomatic or slightly pruritic. There are many options for the treatment of disseminated superficial actinic porokeratosis, including topical diclofenac, photodynamic therapy (PDT), 5-fluorouracil (5-FU), imiquimod, vitamin D analogs, retinoids, and lasers. These lesions are considered precancerous. There is a 7.5 to 10% risk of malignant transformation to squamous cell carcinoma or basal cell carcinoma.
Lalaki anu umurna 52 taun, samemehna séhat, sumping kalayan datar, bentuk cincin dina tungtung jempol kaopatna, anu parantos aya salami 2 taun tanpa nyababkeun gejala. Ieu dimimitian salaku leutik, nabrak teuas tur tumuwuh kaluar kana waktu. Sanajan nyobian sagala rupa perlakuan kawas cryotherapy, creams, antifungals, sarta antibiotik, patch teu meunang hadé. Examining eta raket jeung dermocopsy a némbongkeun garing, puseur beureum kalawan kandel, wates kasar. Sapotong leutik kulit dicokot tina ujung patch némbongkeun tumuwuhna sél abnormal dina lapisan luar kulit, confirming diagnosis porokeratosis of Mibelli.
A 52-year-old man with no past medical history presented with an asymptomatic annular atrophic patch on the distal portion of the fourth toe of 2 years’ duration. The lesion began as a small keratotic papule that gradually enlarged centrifugally. He had received multiple treatments including cryotherapy, topical corticosteroids, antifungals, and antibiotics without improvement. Dermoscopic examination revealed a scaly atrophic erythematous central area with a sharply demarcated peripheral hyperkeratotic structure. A skin biopsy of the edge of the lesion revealed a cornoid lamella with a column of parakeratotic cells extending from an invagination of the epidermis with absence of granular layer. The clinicopathologic correlation was consistent with porokeratosis of Mibelli.
A 52-year-old man with no past medical history presented with an asymptomatic annular atrophic patch on the distal portion of the fourth toe of 2 years’ duration. The lesion began as a small keratotic papule that gradually enlarged centrifugally. He had received multiple treatments including cryotherapy, topical corticosteroids, antifungals, and antibiotics without improvement. Dermoscopic examination revealed a scaly atrophic erythematous central area with a sharply demarcated peripheral hyperkeratotic structure. A skin biopsy of the edge of the lesion revealed a cornoid lamella with a column of parakeratotic cells extending from an invagination of the epidermis with absence of granular layer. The clinicopathologic correlation was consistent with porokeratosis of Mibelli.
Mindeng biopsy dipigawé sabab bisa kasampak sarupa actinic keratosis atawa carcinoma sél squamous.