Porokeratosis
☆ AI Dermatology — Free Service
Dina hasil Stiftung Warentest 2022 ti Jerman, kapuasan konsumen sareng ModelDerm ngan ukur langkung handap tibatan konsultasi telemedicine anu mayar.
Dina hasil Stiftung Warentest 2022 ti Jerman, kapuasan konsumen sareng ModelDerm ngan ukur langkung handap tibatan konsultasi telemedicine anu mayar.
Tepi keras nu menonjol mangrupakeun ciri.
relevance score : -100.0%
ReferencesPorokeratosis mangrupakeun kaayaan kulit langka anu dicirikeun ku gangguan keratinisasi, nu ngahasilkeun patch nu ngawangun cingcin atawa nabrak kasar dina kulit. Ciri mikroskopikna nyaéta ayana lamella kornoid, susunan husus sél dina lapisan luhur kulit. Porokeratosis mibanda sababaraha bentuk, di antarana disseminated superficial actinic porokeratosis, classical porokeratosis of Mibelli, porokeratosis palmaris plantaris et disseminatum, jeung linear porokeratosis. Penting pikeun dicatet yén porokeratosis tiasa berpotensi janten kanker kulit. Cara pangalusna pikeun ngadiagnosis porokeratosis nyaéta ngaliwatan biopsi wates anu diperkaya, sanajan ayeuna teu aya protokol perawatan standar.
Porokeratosis is an uncommon dermatologic disorder. It is a disorder of keratinization that presents with keratotic papules or annular plaques with an elevated border. It has a distinct histologic hallmark of cornoid lamella, which is a column of tightly fitted parakeratotic cells in the upper epidermis. There are multiple clinical variants of porokeratosis, including disseminated superficial actinic porokeratosis, classical porokeratosis of Mibelli, porokeratosis palmaris plantaris et disseminatum, and linear porokeratosis. Porokeratosis is a precancerous lesion that can undergo malignant transformation. Evaluation of porokeratosis is best with a biopsy of the elevated border. There are no standard guidelines for treatment.
Porokeratosis is an uncommon dermatologic disorder. It is a disorder of keratinization that presents with keratotic papules or annular plaques with an elevated border. It has a distinct histologic hallmark of cornoid lamella, which is a column of tightly fitted parakeratotic cells in the upper epidermis. There are multiple clinical variants of porokeratosis, including disseminated superficial actinic porokeratosis, classical porokeratosis of Mibelli, porokeratosis palmaris plantaris et disseminatum, and linear porokeratosis. Porokeratosis is a precancerous lesion that can undergo malignant transformation. Evaluation of porokeratosis is best with a biopsy of the elevated border. There are no standard guidelines for treatment.
Disseminated superficial actinic porokeratosis (DSAP) mangrupikeun panyakit keratinisasi anu teu kaganggu. Ieu salah sahiji tina genep jenis porokeratosis, sarta ilaharna mangaruhan wewengkon nu leuwih lega dibandingkeun jeung nu séjén (linear, Mibelli's, punctate, palmoplantar disseminated, superficial porokeratosis). Jinis eruptif tina porokeratosis mindeng patali jeung kanker, sistem imun nu lemah, atawa peradangan. Faktor résiko ngalibatkeun genetik, suprési imun, sareng paparan panonpoé. DSAP dimimitian ku lesi pink atawa coklat kalayan pinggiran anu terangkat di wewengkon anu kakeunaan panonpoé, sakapeung nyababkeun gatel leutik. Pangobatan rupa‑rupa sareng tiasa ngawengku krim topikal, terapi cahaya, atawa ubar sapertos 5-fluorouracil atawa retinoid. Lesi ieu dianggap precancerous, kalayan 7,5–10 % kasempetan robah jadi sél skuamosa atawa karsinoma sél basal.
Disseminated superficial actinic porokeratosis (DSAP) is a disease of disordered keratinization. Disseminated superficial actinic porokeratosis is one of six variants of porokeratosis. It has more extensive involvement than most other variants. These other variants include linear porokeratosis, porokeratosis of Mibelli, punctate porokeratosis, porokeratosis palmaris et plantaris disseminata, and disseminated superficial porokeratosis. The eruptive form of porokeratosis is associated with malignancy, immunosuppression, and a proinflammatory state. Risk factors for porokeratosis include genetics, immunosuppression, and ultraviolet light. The lesions in disseminated superficial actinic porokeratosis start as pink to brown papules and macules with a raised border in sun-exposed areas that can be asymptomatic or slightly pruritic. There are many options for the treatment of disseminated superficial actinic porokeratosis, including topical diclofenac, photodynamic therapy (PDT), 5-fluorouracil (5-FU), imiquimod, vitamin D analogs, retinoids, and lasers. These lesions are considered precancerous. There is a 7.5 to 10% risk of malignant transformation to squamous cell carcinoma or basal cell carcinoma.
Disseminated superficial actinic porokeratosis (DSAP) is a disease of disordered keratinization. Disseminated superficial actinic porokeratosis is one of six variants of porokeratosis. It has more extensive involvement than most other variants. These other variants include linear porokeratosis, porokeratosis of Mibelli, punctate porokeratosis, porokeratosis palmaris et plantaris disseminata, and disseminated superficial porokeratosis. The eruptive form of porokeratosis is associated with malignancy, immunosuppression, and a proinflammatory state. Risk factors for porokeratosis include genetics, immunosuppression, and ultraviolet light. The lesions in disseminated superficial actinic porokeratosis start as pink to brown papules and macules with a raised border in sun-exposed areas that can be asymptomatic or slightly pruritic. There are many options for the treatment of disseminated superficial actinic porokeratosis, including topical diclofenac, photodynamic therapy (PDT), 5-fluorouracil (5-FU), imiquimod, vitamin D analogs, retinoids, and lasers. These lesions are considered precancerous. There is a 7.5 to 10% risk of malignant transformation to squamous cell carcinoma or basal cell carcinoma.
Lalaki umur 52 taun, saméméhna séhat, datang kalayan lesi datar berbentuk cincin di ujung jempol kaopat, anu geus aya salami 2 taun tanpa gejala. Lesi ieu mimiti leutik, keras, sarta beuki gedé sapanjang waktos. Sanajan geus dicoba rupa‑rupa perlakuan sapertos cryotherapy, krim, antifungal, jeung antibiotik, lesi teu membaik. Pemeriksaan klinis jeung dermatoskopi némbongkeun kulit garing, pusat beureum kalayan tepi kandel jeung kasar. Sampel kulit leutik dicokot ti ujung lesi némbongkeun pertumbuhan sel abnormal di lapisan epidermis, nu mastikeun diagnosis porokeratosis of Mibelli.
A 52-year-old man with no past medical history presented with an asymptomatic annular atrophic patch on the distal portion of the fourth toe of 2 years’ duration. The lesion began as a small keratotic papule that gradually enlarged centrifugally. He had received multiple treatments including cryotherapy, topical corticosteroids, antifungals, and antibiotics without improvement. Dermoscopic examination revealed a scaly atrophic erythematous central area with a sharply demarcated peripheral hyperkeratotic structure. A skin biopsy of the edge of the lesion revealed a cornoid lamella with a column of parakeratotic cells extending from an invagination of the epidermis with absence of granular layer. The clinicopathologic correlation was consistent with porokeratosis of Mibelli.
A 52-year-old man with no past medical history presented with an asymptomatic annular atrophic patch on the distal portion of the fourth toe of 2 years’ duration. The lesion began as a small keratotic papule that gradually enlarged centrifugally. He had received multiple treatments including cryotherapy, topical corticosteroids, antifungals, and antibiotics without improvement. Dermoscopic examination revealed a scaly atrophic erythematous central area with a sharply demarcated peripheral hyperkeratotic structure. A skin biopsy of the edge of the lesion revealed a cornoid lamella with a column of parakeratotic cells extending from an invagination of the epidermis with absence of granular layer. The clinicopathologic correlation was consistent with porokeratosis of Mibelli.
Mindeng biopsi dipigawé sabab lesi bisa katingali sarupa actinic keratosis atawa carcinoma sél squamous.