Acanthosis nigricans
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References
Acanthosis nigricans är en kutan manifestation av ett underliggande tillstånd. Det uppträder ofta i hudveck som nacke, armhålor och ljumskar, och ser ut som sammetslena mörka fläckar med oklara kanter. Detta tillstånd är vanligtvis kopplat till diabetes och insulinresistens, men i sällsynta fall kan det peka på cancer i kroppen. Det kan också dyka upp på grund av hormonproblem eller från att ta specifika mediciner som steroider och p-piller.
Acanthosis nigricans is a cutaneous manifestation of an underlying condition. It usually develops in skin folds, such as the back of the neck, axilla, and groin, where it presents as velvety hyper-pigmented patches with poorly defined borders. Acanthosis nigricans is most commonly associated with diabetes and insulin resistance, but rarely it can be a sign of internal malignancy. It can also occur with hormone disorders or with the use of certain medications like systemic glucocorticoids and oral contraceptives.
Acanthosis nigricans is a cutaneous manifestation of an underlying condition. It usually develops in skin folds, such as the back of the neck, axilla, and groin, where it presents as velvety hyper-pigmented patches with poorly defined borders. Acanthosis nigricans is most commonly associated with diabetes and insulin resistance, but rarely it can be a sign of internal malignancy. It can also occur with hormone disorders or with the use of certain medications like systemic glucocorticoids and oral contraceptives.
Acanthosis nigricans (AN) är ett vanligt hudtillstånd kopplat till olika hälsoproblem som insulinresistens, diabetes, fetma, vissa cancerformer, hormonella problem och reaktioner på mediciner. Att behandla AN fokuserar på att ta itu med de underliggande hälsoproblemen. Inledningsvis kontrollerar läkare efter tecken på insulinresistenssyndrom, vilket inkluderar fetma, högt kolesterol, högt blodtryck och typ 2-diabetes. Läkare ordinerar ofta topical retinoids som första behandlingsval, vilket kan hjälpa till med förtjockning av huden. Däremot kanske de inte helt åtgärdar mörkare hud. Andra behandlingsalternativ som salicylic acid, podophyllin, urea, and calcipotriol behöver också appliceras ofta.
Acanthosis nigricans (AN) is a common dermatologic manifestation of systemic disease that is associated with insulin resistance, diabetes mellitus, obesity, internal malignancy, endocrine disorders, and drug reactions. Treatment of AN primarily focuses on resolution of the underlying disease processes causing the velvety, hyperpigmented, hyperkeratotic plaques found on the skin. Initial considerations for the AN workup include evaluating patients for insulin resistance syndrome characterized by obesity, dyslipidemia, hypertension, and diabetes mellitus type II. For cosmetic treatment, topical retinoids are considered the first-line therapy for insulin-resistant AN by modifying keratinization rate. However, topical tretinoin requires application for long durations and improves hyperkeratosis, but not hyperpigmentation. Topical salicylic acid, podophyllin, urea, and calcipotriol also require frequent application, while TCA peels may provide a faster and less time-intense burden.
Acanthosis nigricans (AN) is a common dermatologic manifestation of systemic disease that is associated with insulin resistance, diabetes mellitus, obesity, internal malignancy, endocrine disorders, and drug reactions. Treatment of AN primarily focuses on resolution of the underlying disease processes causing the velvety, hyperpigmented, hyperkeratotic plaques found on the skin. Initial considerations for the AN workup include evaluating patients for insulin resistance syndrome characterized by obesity, dyslipidemia, hypertension, and diabetes mellitus type II. For cosmetic treatment, topical retinoids are considered the first-line therapy for insulin-resistant AN by modifying keratinization rate. However, topical tretinoin requires application for long durations and improves hyperkeratosis, but not hyperpigmentation. Topical salicylic acid, podophyllin, urea, and calcipotriol also require frequent application, while TCA peels may provide a faster and less time-intense burden.
○ Orsaker
Det förekommer vanligtvis hos individer yngre än 40 år, kan vara genetiskt ärftligt och är associerat med fetma eller endokrinopatier, såsom hypotyreos, akromegali, polycystisk äggstockssjukdom, insulinresistent diabetes eller Cushings sjukdom.
○ Behandling ― OTC-läkemedel
#40% urea cream