Keratoacanthoma - Keratoakantom
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Typiskt Keratoakantom (Keratoacanthoma)
References
Keratoacanthoma (KA) är en frekvent hudtumör känd för sin snabba tillväxt och potential att regrediera på egen hand. Det förekommer vanligtvis hos äldre, ljushyade män med en historia av solskador. Medan kirurgiskt avlägsnande med excision eller Mohs mikrografisk kirurgi är den vanliga behandlingen, finns det olika andra terapialternativ tillgängliga.
Keratoacanthoma (KA) is a common cutaneous tumor characterized by rapid growth and possible spontaneous regression. It most commonly affects older, fair-skinned males with significantly sun damaged skin. Although surgical removal with excision or Mohs micrographic surgery remains the standard of therapy, there are many alternative therapeutic modalities that can be utilized.
Keratoacanthoma (KA) is a common cutaneous tumor characterized by rapid growth and possible spontaneous regression. It most commonly affects older, fair-skinned males with significantly sun damaged skin. Although surgical removal with excision or Mohs micrographic surgery remains the standard of therapy, there are many alternative therapeutic modalities that can be utilized.
Keratoacanthoma (KA) är en låggradig tumör som börjar i vissa körtlar i huden och ser ut som squamous cell carcinoma (SCC) i mikroskop. Det pågår en debatt om huruvida KA ska klassificeras som en form av invasiv SCC.
Keratoacanthoma (KA) is a comparatively common low-grade tumor that initiates in the pilo-sebaceous glands and pathologically mimics squamous cell carcinoma (SCC). Essentially, strong debates confirm classifying keratoacanthoma as a variant of invasive SCC. The clinical behavior of KA is hardly predictable and the differential diagnosis of keratoacanthoma and other conditions with keratoacanthoma-like pseudocarcinomatous epithelial hyperplasia is challenging, both clinically and histopathologically.
Keratoacanthoma (KA) is a comparatively common low-grade tumor that initiates in the pilo-sebaceous glands and pathologically mimics squamous cell carcinoma (SCC). Essentially, strong debates confirm classifying keratoacanthoma as a variant of invasive SCC. The clinical behavior of KA is hardly predictable and the differential diagnosis of keratoacanthoma and other conditions with keratoacanthoma-like pseudocarcinomatous epithelial hyperplasia is challenging, both clinically and histopathologically.
Cutaneous squamous cell carcinoma (cSCC) är den näst vanligaste cancerformen hos människor, särskilt bland äldre individer. Kirurgi används vanligtvis för att behandla cSCC, men för vissa patienter som inte kan opereras eller väljer att inte göra det, kan andra alternativ som intralesionala behandlingar övervägas. Traditionella intralesionala behandlingar (methotrexate or 5-fluorouracil) har använts, men det pågår forskning om nya metoder som intralesional immunterapi och onkolytisk viroterapi. Här kommer vi att titta på olika intralesionala behandlingar för cSCC, allt från klassiska metoder till banbrytande strategier.
Cutaneous squamous cell carcinoma (cSCC) is the second most frequent cancer in humans, and it is especially common in fragile, elderly people. Surgery is the standard treatment for cSCC but intralesional treatments can be an alternative in those patients who are either not candidates or refuse to undergo surgery. Classic intralesional treatments, including methotrexate or 5-fluorouracil, have been implemented, but there is now a landscape of active research to incorporate intralesional immunotherapy and oncolytic virotherapy into the scene, which might change the way we deal with cSCC in the future. In this review, we focus on intralesional treatments for cSCC (including keratoacanthoma), from classic to very novel strategies.
Cutaneous squamous cell carcinoma (cSCC) is the second most frequent cancer in humans, and it is especially common in fragile, elderly people. Surgery is the standard treatment for cSCC but intralesional treatments can be an alternative in those patients who are either not candidates or refuse to undergo surgery. Classic intralesional treatments, including methotrexate or 5-fluorouracil, have been implemented, but there is now a landscape of active research to incorporate intralesional immunotherapy and oncolytic virotherapy into the scene, which might change the way we deal with cSCC in the future. In this review, we focus on intralesional treatments for cSCC (including keratoacanthoma), from classic to very novel strategies.
Under mikroskopet påminner keratoakantom (keratoacanthoma) mycket om skivepitelcancer. Medan vissa patologer klassificerar keratoakantom (keratoacanthoma) som en distinkt enhet och inte en malignitet, utvecklas ungefär 6 % av de kliniska och histologiska keratoakantom (keratoacanthoma) till invasiva och aggressiva skivepitelcancer.
○ Diagnos och behandling
#Dermoscopy
#Skin biopsy