Lupus erythematosus
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ReferencesAtt identifiera och klassificera cutaneous lupus erythematosus (CLE) innebär diagnostiska utmaningar, vilket skiljer den från systemic lupus erythematosus med hudinblandning. Nyligen genomförda studier belyser de genetiska, miljömässiga och immunologiska faktorer som ligger bakom CLE. Läkemedelsinduktion har särskilt identifierats som en av de viktigaste triggerna för CLE. Behandlingen omfattar både topikala och systemiska terapier, inklusive lovande biologiska läkemedel såsom belimumab, rituximab, ustekinumab, anifrolumab och BIIB059, med påvisad effekt i kliniska prövningar.
Diagnostic challenges exist in better defining cutaneous lupus erythematosus (CLE) as an independent disease distinct from systemic lupus erythematosus with cutaneous features and further classifying CLE based on clinical, histological, and laboratory features. Recent mechanistic studies revealed more genetic variations, environmental triggers, and immunologic dysfunctions that are associated with CLE. Drug induction specifically has emerged as one of the most important triggers for CLE. Treatment options include topical agents and systemic therapies, including newer biologics such as belimumab, rituximab, ustekinumab, anifrolumab, and BIIB059 that have shown good clinical efficacy in trials.
Diagnostic challenges exist in better defining cutaneous lupus erythematosus (CLE) as an independent disease distinct from systemic lupus erythematosus with cutaneous features and further classifying CLE based on clinical, histological, and laboratory features. Recent mechanistic studies revealed more genetic variations, environmental triggers, and immunologic dysfunctions that are associated with CLE. Drug induction specifically has emerged as one of the most important triggers for CLE. Treatment options include topical agents and systemic therapies, including newer biologics such as belimumab, rituximab, ustekinumab, anifrolumab, and BIIB059 that have shown good clinical efficacy in trials.
Cutaneous lupus erythematosus (CLE) omfattar olika hudproblem, varav några kan vara kopplade till andra hälsoproblem. Tillståndet delas in i flera typer, till exempel akut CLE (ACLE), subakut CLE (SCLE) och kronisk CLE (CCLE). CCLE inkluderar discoid lupus erythematosus (DLE), LE profundus (LEP), chilblain cutaneous lupus och lupus tumidus.
Cutaneous lupus erythematosus (CLE) encompasses a wide range of dermatologic manifestations, which may or may not be associated with the development of systemic disease. Cutaneous lupus is divided into several sub-types, including acute CLE (ACLE), sub-acute CLE (SCLE) and chronic CLE (CCLE). CCLE includes discoid lupus erythematosus (DLE), LE profundus (LEP), chilblain cutaneous lupus and lupus tumidus.
Cutaneous lupus erythematosus (CLE) encompasses a wide range of dermatologic manifestations, which may or may not be associated with the development of systemic disease. Cutaneous lupus is divided into several sub-types, including acute CLE (ACLE), sub-acute CLE (SCLE) and chronic CLE (CCLE). CCLE includes discoid lupus erythematosus (DLE), LE profundus (LEP), chilblain cutaneous lupus and lupus tumidus.
Lupus erythematosus är en grupp autoimmuna sjukdomar som kan påverka olika delar av kroppen. Vissa typer, som systemic lupus erythematosus (SLE), påverkar flera organ, medan andra, som cutaneous lupus erythematosus (CLE), främst påverkar huden. Vi kategoriserar olika typer av CLE baserat på en kombination av kliniska tecken, vävnadsundersökning och blodprover, men det finns stor variation mellan individer. Hudproblem utvecklas ofta på grund av faktorer som exponering för solljus, rökning eller vissa mediciner.
Lupus erythematosus comprises a spectrum of autoimmune diseases that may affect various organs (systemic lupus erythematosus [SLE]) or the skin only (cutaneous lupus erythematosus [CLE]). Typical combinations of clinical, histological and serological findings define clinical subtypes of CLE, yet there is high interindividual variation. Skin lesions arise in the course of triggers such as ultraviolet (UV) light exposure, smoking or drugs
Lupus erythematosus comprises a spectrum of autoimmune diseases that may affect various organs (systemic lupus erythematosus [SLE]) or the skin only (cutaneous lupus erythematosus [CLE]). Typical combinations of clinical, histological and serological findings define clinical subtypes of CLE, yet there is high interindividual variation. Skin lesions arise in the course of triggers such as ultraviolet (UV) light exposure, smoking or drugs
Orsaken till lupus erythematosus är oklar. Bland enäggstvillingar finns en 24 % risk att den andra också blir drabbad om den ena har sjukdomen. Kvinnliga könshormoner, solljus, rökning, D‑vitaminbrist och vissa infektioner tros också öka risken.
Behandling kan bestå av NSAID, kortikosteroider, immunsuppressiva medel, hydroxychloroquine och methotrexate. Även om kortikosteroider är effektiva, kan långvarig användning ge biverkningar.