Porokeratosis - Porokeratos
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I Stiftung Warentest-resultaten 2022 från Tyskland var konsumentnöjdheten med ModelDerm bara något lägre än med betalda telemedicinkonsultationer.
I Stiftung Warentest-resultaten 2022 från Tyskland var konsumentnöjdheten med ModelDerm bara något lägre än med betalda telemedicinkonsultationer.
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ReferencesPorokeratosis är ett sällsynt hudtillstånd som kännetecknas av keratiniseringsproblem, vilket resulterar i upphöjda, ringformade fläckar eller grova knölar på huden. Dess avgörande särdrag under mikroskopet är närvaron av cornoidlamella, ett specifikt arrangemang av celler i hudens översta lager. Porokeratosis finns i olika former, till exempel disseminated superficial actinic porokeratosis, classical porokeratosis of Mibelli, porokeratosis palmaris plantaris et disseminatum, and linear porokeratosis. Det är viktigt att notera att porokeratosis potentiellt kan utvecklas till hudcancer. Det bästa sättet att diagnostisera porokeratosis är genom en biopsi av den upphöjda kanten, även om det för närvarande inte finns något standardbehandlingsprotokoll.
Porokeratosis is an uncommon dermatologic disorder. It is a disorder of keratinization that presents with keratotic papules or annular plaques with an elevated border. It has a distinct histologic hallmark of cornoid lamella, which is a column of tightly fitted parakeratotic cells in the upper epidermis. There are multiple clinical variants of porokeratosis, including disseminated superficial actinic porokeratosis, classical porokeratosis of Mibelli, porokeratosis palmaris plantaris et disseminatum, and linear porokeratosis. Porokeratosis is a precancerous lesion that can undergo malignant transformation. Evaluation of porokeratosis is best with a biopsy of the elevated border. There are no standard guidelines for treatment.
Porokeratosis is an uncommon dermatologic disorder. It is a disorder of keratinization that presents with keratotic papules or annular plaques with an elevated border. It has a distinct histologic hallmark of cornoid lamella, which is a column of tightly fitted parakeratotic cells in the upper epidermis. There are multiple clinical variants of porokeratosis, including disseminated superficial actinic porokeratosis, classical porokeratosis of Mibelli, porokeratosis palmaris plantaris et disseminatum, and linear porokeratosis. Porokeratosis is a precancerous lesion that can undergo malignant transformation. Evaluation of porokeratosis is best with a biopsy of the elevated border. There are no standard guidelines for treatment.
Disseminated superficial actinic porokeratosis (DSAP) är en sjukdom med störd keratinisering. Det är en av sex typer av porokeratosis, och den drabbar vanligtvis större områden jämfört med de andra (linear porokeratosis (linear), porokeratosis of Mibelli (Mibelli's), punctate porokeratosis (punctate), porokeratosis palmaris et plantaris disseminata (palmoplantar disseminated) och disseminated superficial porokeratosis (superficial porokeratosis)). Den eruptiva typen av porokeratosis länkar ofta till cancer, försvagad immunitet eller inflammation. Riskfaktorer involverar genetik, immundämpning och solexponering. DSAP börjar som rosa eller bruna knölar med upphöda kanter i solexponerade områden, vilket ibland orsakar lätt klåda. Behandlingarna varierar och kan inkludera aktuella krämer, ljusterapi eller mediciner som 5-fluorouracil eller retinoider. Dessa lesioner anses vara precancerösa, med en 7.5‑10 % chans att förvandlas till skivepitelcancer eller basalcellscancer.
Disseminated superficial actinic porokeratosis (DSAP) is a disease of disordered keratinization. Disseminated superficial actinic porokeratosis is one of six variants of porokeratosis. It has more extensive involvement than most other variants. These other variants include linear porokeratosis, porokeratosis of Mibelli, punctate porokeratosis, porokeratosis palmaris et plantaris disseminata, and disseminated superficial porokeratosis. The eruptive form of porokeratosis is associated with malignancy, immunosuppression, and a proinflammatory state. Risk factors for porokeratosis include genetics, immunosuppression, and ultraviolet light. The lesions in disseminated superficial actinic porokeratosis start as pink to brown papules and macules with a raised border in sun-exposed areas that can be asymptomatic or slightly pruritic. There are many options for the treatment of disseminated superficial actinic porokeratosis, including topical diclofenac, photodynamic therapy (PDT), 5-fluorouracil (5-FU), imiquimod, vitamin D analogs, retinoids, and lasers. These lesions are considered precancerous. There is a 7.5 to 10% risk of malignant transformation to squamous cell carcinoma or basal cell carcinoma.
Disseminated superficial actinic porokeratosis (DSAP) is a disease of disordered keratinization. Disseminated superficial actinic porokeratosis is one of six variants of porokeratosis. It has more extensive involvement than most other variants. These other variants include linear porokeratosis, porokeratosis of Mibelli, punctate porokeratosis, porokeratosis palmaris et plantaris disseminata, and disseminated superficial porokeratosis. The eruptive form of porokeratosis is associated with malignancy, immunosuppression, and a proinflammatory state. Risk factors for porokeratosis include genetics, immunosuppression, and ultraviolet light. The lesions in disseminated superficial actinic porokeratosis start as pink to brown papules and macules with a raised border in sun-exposed areas that can be asymptomatic or slightly pruritic. There are many options for the treatment of disseminated superficial actinic porokeratosis, including topical diclofenac, photodynamic therapy (PDT), 5-fluorouracil (5-FU), imiquimod, vitamin D analogs, retinoids, and lasers. These lesions are considered precancerous. There is a 7.5 to 10% risk of malignant transformation to squamous cell carcinoma or basal cell carcinoma.
En 52-årig man, tidigare frisk, kom in med en platt, ringformad lapp på den distala delen av den fjärde tån, som hade legat där i 2 år utan att ge några symtom. Det började som en liten keratinös papul som växte centrifugalt med tiden. Trots att man provat olika behandlingar som kryoterapi, topikala kortikosteroider, antifungala medel och antibiotika, blev lesionen inte bättre. En noggrann undersökning med dermoskopi visade ett fjälligt, atrofiskt, erytroft centralt område med en skarpt avgränsad periferiell hyperkeratotisk struktur. En hudbiopsi från lesionens kant avslöjade en cornoid lamella med en kolumn av parakeratotiska celler som sträcker sig från en invagination i epidermis med avsaknad av det granulerade lagret, vilket bekräftar diagnosen porokeratosis of Mibelli.
A 52-year-old man with no past medical history presented with an asymptomatic annular atrophic patch on the distal portion of the fourth toe of 2 years’ duration. The lesion began as a small keratotic papule that gradually enlarged centrifugally. He had received multiple treatments including cryotherapy, topical corticosteroids, antifungals, and antibiotics without improvement. Dermoscopic examination revealed a scaly atrophic erythematous central area with a sharply demarcated peripheral hyperkeratotic structure. A skin biopsy of the edge of the lesion revealed a cornoid lamella with a column of parakeratotic cells extending from an invagination of the epidermis with absence of granular layer. The clinicopathologic correlation was consistent with porokeratosis of Mibelli.
A 52-year-old man with no past medical history presented with an asymptomatic annular atrophic patch on the distal portion of the fourth toe of 2 years’ duration. The lesion began as a small keratotic papule that gradually enlarged centrifugally. He had received multiple treatments including cryotherapy, topical corticosteroids, antifungals, and antibiotics without improvement. Dermoscopic examination revealed a scaly atrophic erythematous central area with a sharply demarcated peripheral hyperkeratotic structure. A skin biopsy of the edge of the lesion revealed a cornoid lamella with a column of parakeratotic cells extending from an invagination of the epidermis with absence of granular layer. The clinicopathologic correlation was consistent with porokeratosis of Mibelli.
Ofta görs en biopsi eftersom den kan se ut som aktinisk keratos eller skivepitelcancer.