Acute generalized exanthematous pustulosis
Acute generalized exanthematous pustulosis (AGEP) ni mmenyuko wa nadra wa ngozi ambao katika 90% ya kesi unahusiana na utumiaji wa dawa. Acute generalized exanthematous pustulosis ina sifa ya milipuko ya ghafla ya ngozi ambayo hutokea kwa wastani siku tano baada ya kuanza kwa dawa. Milipuko hii ni pustules, i.e. mlipuko mdogo nyekundu nyeupe au nyekundu ya ngozi ambayo ina mawingu au purulent nyenzo (usaha). Vidonda vya ngozi kawaida huisha ndani ya siku 1-3 baada ya kusimamishwa kwa dawa.
☆ Katika matokeo ya 2022 ya Stiftung Warentest kutoka Ujerumani, kuridhika kwa watumiaji na ModelDerm kulikuwa chini kidogo kuliko na mashauriano ya matibabu ya simu yanayolipishwa.
Vidonda vilivyoenea na erythema na pustules huonekana ghafla.
References
Acute generalized exanthematous pustulosis (AGEP) ni mmenyuko wa ngozi unaoonyeshwa na matuta madogo yaliyojaa usaha kwenye msingi wa ngozi nyekundu. Kwa kawaida hutokea mtu anapotumia dawa fulani, kama vile viuavijasumu, na kusambaa kwa haraka kwenye mwili wote. Baada ya kuacha dawa ya kuchochea, dalili kawaida hupotea ndani ya wiki mbili, mara nyingi huacha kumwaga kwa ngozi. Ingawa kwa kawaida si mbaya na pekee kwenye ngozi, kesi kali zinaweza kuainishwa pamoja na athari nyingine mbaya za ngozi kama vile Stevens-Johnson syndrome au toxic epidermal necrolysis. Matibabu kimsingi ni huduma ya kuunga mkono, na ubashiri wa utatuzi kamili wa ugonjwa kawaida ni bora.
Acute generalized exanthematous pustulosis (AGEP) is an adverse cutaneous reaction characterized by sterile pinpoint nonfollicular pustules atop an erythematous background. Symptoms most often occur in the setting of medication exposure, such as systemic antibiotics, rapidly become generalized, followed by desquamation and resolution within about two weeks of discontinuing the offending trigger. Although mostly self-limited without systemic involvement, severe cases are classified alongside other cutaneous adverse reactions such as Stevens-Johnson syndrome, toxic epidermal necrolysis, and drug reaction with eosinophilia and systemic symptoms. Treatment is primarily supportive, and the prognosis for complete resolution is excellent.
Acute generalized exanthematous pustulosis (AGEP) is an adverse cutaneous reaction characterized by sterile pinpoint nonfollicular pustules atop an erythematous background. Symptoms most often occur in the setting of medication exposure, such as systemic antibiotics, rapidly become generalized, followed by desquamation and resolution within about two weeks of discontinuing the offending trigger. Although mostly self-limited without systemic involvement, severe cases are classified alongside other cutaneous adverse reactions such as Stevens-Johnson syndrome, toxic epidermal necrolysis, and drug reaction with eosinophilia and systemic symptoms. Treatment is primarily supportive, and the prognosis for complete resolution is excellent.
Recent experimental data reviewed herein are supportive of an early role of drug-induced innate immune activation and innate cytokines such as interleukin (IL)-1, IL-36, and IL-17 in the pathogenesis of AGEP. This explains the rapid onset and neutrophilic character of the cutaneous inflammation.
Mzee wa miaka 76 alifika kwenye chumba cha dharura kwa sababu ngozi yake ilikuwa imebadilika kwa siku mbili zilizopita. Madaktari walipata mabaka mekundu na kuinua maeneo kwenye shina na mikono na miguu. Kadiri muda ulivyosonga, mabaka haya yaliungana, na akapata matuta kama chunusi kwenye maeneo mekundu. Uchunguzi ulionyesha hesabu ya juu ya seli nyeupe za damu na aina nyingi zinazoitwa neutrophils, na viwango vilivyoongezeka vya C-reactive protein.
A 76-year-old male patient presented as an emergency due to a 2-day history of skin changes. Physical examination revealed disseminated erythematous macules and plaques on the trunk and extremities. In the further course, confluence of the macules and non-follicular pustulosis developed in the area of erythema. Laboratory tests revealed leukocytosis with neutrophils and elevated C-reactive protein.
A 76-year-old male patient presented as an emergency due to a 2-day history of skin changes. Physical examination revealed disseminated erythematous macules and plaques on the trunk and extremities. In the further course, confluence of the macules and non-follicular pustulosis developed in the area of erythema. Laboratory tests revealed leukocytosis with neutrophils and elevated C-reactive protein.
