Taarifa zaidi ― Kiswahili

Mwanamke mwenye umri wa miaka 26 alikuja kwenye kliniki yetu akilalamika kuhusu upele unaowasha kwenye miguu yake ambao amekuwa nao kwa miaka 10. Licha ya kutumia krimu za steroid na cream ya tazarotene, upele haukuwa bora. Hakuwa na historia yoyote ya familia husika. Tulipomchunguza, tuligundua mabaka yameinuliwa, makali kwenye sehemu ya mbele ya miguu yake, ambayo yalifanana na ugonjwa uitwao lichen amyloidosis.
A 26-year-old woman presented to our clinic with an itchy rash on her legs that had persisted for 10 years. The rash had previously been treated with topical steroids and tazarotene cream, with no improvement. The patient’s family history was noncontributory. A physical examination showed discrete and coalescing hyperkeratotic tan-brown papules on the pretibial surfaces, consistent with lichen amyloidosis.

Lichen Amyloidosis ni hali ya nadra ya ngozi inayohusishwa na kuwashwa mara kwa mara kwa sababu isiyojulikana. Kwa kawaida huonekana kama makundi ya mabaka yaliyoinuliwa, yaliyobadilika rangi kwenye nyuso za nje za ngozi. Lichen Amyloidosis kawaida huonekana kwa watu wenye umri wa miaka 50 hadi 60 na kwa bahati mbaya, hakuna tiba yake. Matibabu yanayopatikana sasa kwa kawaida hayafanyi kazi vizuri.
Lichen Amyloidosis (LA) is an uncommon, primary cutaneous amyloidosis associated with chronic, idiopathic pruritus. Clinical presentation of LA includes skin colored to hyperpigmented, papules coalescing into plaques with a rippled appearance on the extensors.1 LA most commonly presents in the fifth to sixth decade of life and has no curative treatments. Overall response to current therapies is poor.

Lichen amyloidosis ni hali ya ngozi kuwashwa kwa muda mrefu. Inajulikana kwa makundi ya matuta mazito yanayopatikana hasa mgongoni, mapajani, mapajani na mikononi. Inapochunguzwa kwa darubini, Lichen amyloidosis inaonyesha mkusanyiko wa amiloidi kwenye safu ya juu ya ngozi pamoja na unene na upanuzi wa safu ya nje ya ngozi. Ingawa sababu kamili ya Lichen amyloidosis bado haijaeleweka kikamilifu, tafiti za awali zimeihusisha na mambo kama vile kusugua au msuguano kwenye ngozi, kifo cha seli, maambukizi ya virusi, miongoni mwa mengine. Lichen amyloidosis inaonekana kuhusishwa na hali zingine kadhaa za ngozi (atopic dermatitis, lichen planus, mycosis fungoides) .
Lichen amyloidosis (LA) is a chronic pruritic skin disorder characterized by multiple grouped hyperkeratotic papules, predominantly located on the back, shins, thighs, and arms. Histological analysis of LA shows amyloid deposition in the papillary dermis and hyperkeratosis and acanthosis of the epidermis. The exact pathogenesis of LA has not yet been elucidated; however, prior reports have implicated frictional epidermal damage, apoptosis, viral infection, and many other triggers. LA is reportedly associated with several skin disorders, including atopic dermatitis (AD), lichen planus, and mycosis fungoides.