Intraepithelial carcinoma (Bowen disease) - Intraepithelial Carcinoma (Ugonjwa Wa Bowen)https://en.wikipedia.org/wiki/Squamous_cell_skin_cancer
Intraepithelial Carcinoma (Ugonjwa Wa Bowen) (Intraepithelial carcinoma (Bowen disease)) inaonyesha ukuaji wa seli za squamous zisizo za kawaida katika unene wote wa epidermis. Tumor nzima imefungwa kwenye epidermis na haijapita ndani ya dermis. Ugonjwa huu, ingawa unachukuliwa kama saratani, hausambaa kama saratani za kawaida (yaani ni saratani yenye tabia ya kupungua).

Kawaida huonekana kama eneo lenye rangi nyekundu, magamba au ukoko popote kwenye mwili. Eneo linaloathiriwa zaidi ni miguu ya chini.

Inatibiwa kwa njia mbalimbali za matibabu kama vile cryotherapy, curettage, cautery, photodynamic therapy, au upasuaji.

○ Uchunguzi na Tiba
#Dermoscopy
#Skin biopsy
#Mohs surgery
#Photodynamic therapy
☆ AI Dermatology — Free Service
Katika matokeo ya 2022 ya Stiftung Warentest kutoka Ujerumani, kuridhika kwa watumiaji na ModelDerm kulikuwa chini kidogo kuliko na mashauriano ya matibabu ya simu yanayolipishwa.
  • Kesi ya kawaida — Intraepithelial Carcinoma (Ugonjwa wa Bowen) (Intraepithelial carcinoma (Bowen disease)) inaweza kutambuliwa kimakosa kama ukurutu wa muda mrefu usio na mwasho.
  • Cutaneous horn ― Tofauti na warts, hujidhihirisha kama kinundu kigumu, na biopsy ni muhimu ili kuwatofautisha na ugonjwa mbaya.
  • Ikiwa jeraha litaendelea kwa muda mrefu, saratani ya ngozi inapaswa kuzingatiwa.
  • Intraepithelial Carcinoma (Ugonjwa wa Bowen) (Intraepithelial carcinoma (Bowen disease)) — kesi ya kawaida.
  • Katika kesi hii, Irritated seborrheic keratosis inaweza pia kuchukuliwa kama utambuzi wa uwezekano wa kutofautisha.
  • Mara nyingi hukosa ugonjwa wa mzio (kwa mfano, nummular eczema).
  • Intraepithelial Carcinoma (Ugonjwa wa Bowen) (Intraepithelial carcinoma (Bowen disease)) – kesi ya kawaida.
  • Kesi nyingine ya kawaida ina sifa sawa za kimolojia kwa hali ya mzio.
References Bowen's Disease 35287414 
NIH
Bowen's disease (BD) ni aina ya saratani ya ngozi inayotokea kwenye tabaka la nje la ngozi (epidermis). Ni zaidi ya kawaida katika watu wa Caucasus na mara nyingi hutokea katika maeneo yenye mwanga wa jua, ingawa inaweza kuonekana sehemu nyingine pia. BD kawaida huonekana kama kidonda kimoja. BD mara nyingi ni ishara ya onyo kabla ya saratani ya ngozi ya aina mbaya zaidi kutokea. Ili kugundua BD, madaktari kwa kawaida hutegemea uchunguzi wa sampuli za tishu chini ya darubini (biopsy).
Bowen's disease (BD) is an in-situ squamous cell carcinoma of epidermis. The etiology of BD is multifactorial with high incidence among Caucasians. BD is common in photo-exposed areas of skin, but other sites can also be involved. Lesions are usually solitary. The morphology of BD differs based on age of the lesion, site of origin, and the degree of keratinization. BD is considered as the lull before the storm, which precedes an overt squamous cell carcinoma. Histopathology is the gold standard diagnostic modality to confirm the diagnosis.
 Bowen disease - Case reports 17001052 
NIH
Bowen's disease huathiri zaidi watu weupe wenye umri wa zaidi ya miaka 60. Sababu kuu za hatari ni pamoja na kupigwa na jua kwa muda mrefu, udhoofikaji wa mfumo wa kinga, mfiduo wa arseniki, na maambukizi ya HPV ya ngozi. Aina za HPV 16, 18, 34, na 48 zinahusishwa na Bowen's disease katika maeneo ya siri. Uhusika wa HPV katika kesi zisizo za uzazi bado haijulikani vizuri.
Bowen disease is most commonly found in white patients over 60 years old. Other risk factors include chronic sun exposure, immunosuppression, arsenic exposure and cutaneous human papillomavirus (HPV) infection. HPV types 16, 18, 34 and 48 cause Bowen disease at genital sites; the role of HPV in nongenital cases of Bowen disease is less well defined. HPV types 2, 16, 34 and 35 have been rarely identified within nongenital lesions.