Prurigo nodularis
☆ Katika matokeo ya 2022 ya Stiftung Warentest kutoka Ujerumani, kuridhika kwa watumiaji na ModelDerm kulikuwa chini kidogo kuliko na mashauriano ya matibabu ya simu yanayolipishwa.
References
Prurigo nodularis ni hali ya ngozi ya muda mrefu inayojulikana na matuta na vinundu vingi thabiti, kwa kawaida hupatikana kwenye sehemu za nje za mikono na miguu. Matuta haya yanaweza kutofautiana kwa rangi kutoka kwa rangi ya nyama hadi ya waridi na huwashwa sana. Wanaweza kuathiri watu wa umri wowote na mara nyingi huhusishwa na magonjwa mengine ya ngozi ambayo husababisha kuwasha kwa muda mrefu, kama ugonjwa wa atopiki. Chaguzi za matibabu ni pamoja na dawa kali za kuzuia kuwasha, dawa zinazoathiri mfumo wa kinga, na dawa zinazolenga mfumo wa neva. Kusimamia prurigo nodularis kawaida huhusisha tiba ya muda mrefu.
Prurigo nodularis is a chronic disorder of the skin that is classically seen as multiple, firm, flesh to pink colored papules, plaques and nodules commonly located on the extensor surfaces of the extremities. The lesions are very pruritic and can occur in any age group. It is commonly associated with another disease such as atopic dermatitis or any dermatoses associated with chronic pruritus. The therapeutic approach is wide-arrayed ranging from treatments that act as - potent antipruritics, immunomodulators, and neuromodulators. Treatment in an established case is prolonged and improving patient compliance with education and counseling is important.
Prurigo nodularis is a chronic disorder of the skin that is classically seen as multiple, firm, flesh to pink colored papules, plaques and nodules commonly located on the extensor surfaces of the extremities. The lesions are very pruritic and can occur in any age group. It is commonly associated with another disease such as atopic dermatitis or any dermatoses associated with chronic pruritus. The therapeutic approach is wide-arrayed ranging from treatments that act as - potent antipruritics, immunomodulators, and neuromodulators. Treatment in an established case is prolonged and improving patient compliance with education and counseling is important.
Matibabu kawaida huhusisha kutumia krimu au sindano za steroids kwenye eneo lililoathirika. Katika visa vikali zaidi au vya ukaidi, matibabu kama vile tiba nyepesi au dawa zinazokandamiza mfumo wa kinga zinaweza kuhitajika. Thalidomide na lenalidomide ni chaguo kwa kesi kali, lakini zinaweza kuwa na madhara makubwa. Matibabu mapya zaidi (opioid receptor antagonists, neurokinin-1 receptor antagonists) yanaonyesha ahadi katika kutibu prurigo nodularis yenye madhara machache ikilinganishwa na thalidomide au lenalidomide.
Treatment typically relies on the use of topical or intralesional steroids, though more severe or recalcitrant cases often necessitate the use of phototherapy or systemic immunosuppressives. Thalidomide and lenalidomide can both be used in severe cases; however, their toxicity profile makes them less favorable. Opioid receptor antagonists and neurokinin-1 receptor antagonists represent two novel families of therapeutic agents which may effectively treat PN with a lower toxicity profile than thalidomide or lenalidomide.
Treatment typically relies on the use of topical or intralesional steroids, though more severe or recalcitrant cases often necessitate the use of phototherapy or systemic immunosuppressives. Thalidomide and lenalidomide can both be used in severe cases; however, their toxicity profile makes them less favorable. Opioid receptor antagonists and neurokinin-1 receptor antagonists represent two novel families of therapeutic agents which may effectively treat PN with a lower toxicity profile than thalidomide or lenalidomide.
Chronic prurigo ni hali ya ngozi inayojulikana na kuwashwa kwa muda mrefu (hudumu zaidi ya wiki 6) , vidonda vya ngozi vinavyohusiana na mikwaruzo, na historia ya kukwaruza mara kwa mara. Inahusisha neuroinflammation na fibrosis kwenye ngozi.
Chronic prurigo (CPG) is a neuroinflammatory, fibrotic dermatosis that is defined by the presence of chronic pruritus (itch lasting longer than 6 weeks), scratch-associated pruriginous skin lesions and history of repeated scratching.
Chronic prurigo (CPG) is a neuroinflammatory, fibrotic dermatosis that is defined by the presence of chronic pruritus (itch lasting longer than 6 weeks), scratch-associated pruriginous skin lesions and history of repeated scratching.
Prurigo nodularis ni tatizo la ngozi la muda mrefu linalojulikana na vinundu kuwasha. Hatujui hasa ni nini husababisha, lakini inaonekana kwamba masuala ya kinga na mishipa huchukua jukumu katika mzunguko wa kuwasha. Kwa sasa, hakuna matibabu yoyote yaliyoidhinishwa na FDA ya Marekani mahususi kwa prurigo nodularis.
Prurigo nodularis is a long-lasting skin problem marked by itchy nodules. We don't know exactly what causes it, but it seems that immune and nerve issues play a role in the itch-scratch cycle. Right now, there aren't any treatments approved by the US FDA specifically for prurigo nodularis.
Prurigo nodularis is a long-lasting skin problem marked by itchy nodules. We don't know exactly what causes it, but it seems that immune and nerve issues play a role in the itch-scratch cycle. Right now, there aren't any treatments approved by the US FDA specifically for prurigo nodularis.
○ Matibabu - Dawa za OTC
Kuosha eneo la vidonda na sabuni haisaidii kabisa na inaweza kuwa mbaya zaidi. Mafuta ya OTC steroid yanaweza kusaidia kupunguza dalili, lakini kwa kawaida yanahitaji kutumika kwa wiki kadhaa ili kuboresha. Kuendelea kuchukua antihistamines pia husaidia kupunguza kuwasha.
#OTC steroid ointment
#OTC antihistamine
○ Matibabu
#Intralesional triamcinolone injection