Amyloidosis - Амилоидоз
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Хусусиятҳои чеҳраи классикии Амилоидоз (Amyloidosis)
References
Духтари 26-сола ба клиникаи мо бо шикояти хориш дар пояш омад, ки 10 сол боз дошт. Сарфи назар аз истифодаи кремҳои стероидӣ ва креми тазаротен, доғ беҳтар нашуд. Вай таърихи оилавии дахлдор надошт. Вақте ки мо ӯро муоина кардем, дар пеши пойҳояш часбҳои баланд ва дағал пайдо кардем, ки ба бемории lichen amyloidosis мувофиқат мекарданд.
A 26-year-old woman presented to our clinic with an itchy rash on her legs that had persisted for 10 years. The rash had previously been treated with topical steroids and tazarotene cream, with no improvement. The patient’s family history was noncontributory. A physical examination showed discrete and coalescing hyperkeratotic tan-brown papules on the pretibial surfaces, consistent with lichen amyloidosis.
A 26-year-old woman presented to our clinic with an itchy rash on her legs that had persisted for 10 years. The rash had previously been treated with topical steroids and tazarotene cream, with no improvement. The patient’s family history was noncontributory. A physical examination showed discrete and coalescing hyperkeratotic tan-brown papules on the pretibial surfaces, consistent with lichen amyloidosis.
Lichen Amyloidosis як ҳолати нодири пӯст аст, ки бо хориши доимии сабабҳои номаълум алоқаманд аст. Он одатан ҳамчун кластерҳои часпакҳои баландшуда ва рангоранг дар сатҳи берунии пӯст зоҳир мешавад. Lichen Amyloidosis одатан дар одамони синнашон аз 50 то 60-сола пайдо мешавад ва мутаассифона, табобате нест. Табобатҳое, ки ҳоло дастрасанд, одатан хуб кор намекунанд.
Lichen Amyloidosis (LA) is an uncommon, primary cutaneous amyloidosis associated with chronic, idiopathic pruritus. Clinical presentation of LA includes skin colored to hyperpigmented, papules coalescing into plaques with a rippled appearance on the extensors.1 LA most commonly presents in the fifth to sixth decade of life and has no curative treatments. Overall response to current therapies is poor.
Lichen Amyloidosis (LA) is an uncommon, primary cutaneous amyloidosis associated with chronic, idiopathic pruritus. Clinical presentation of LA includes skin colored to hyperpigmented, papules coalescing into plaques with a rippled appearance on the extensors.1 LA most commonly presents in the fifth to sixth decade of life and has no curative treatments. Overall response to current therapies is poor.
Lichen amyloidosis як ҳолати хориши пӯсти дарозмуддат аст. Он барои кластерҳои ғафсшуда маълум аст, ки асосан дар пушт, шинҳо, ронҳо ва дастҳо пайдо мешаванд. Вақте ки дар зери микроскоп муоина карда мешавад, Lichen amyloidosis ҷамъшавии амилоидро дар қабати болоии пӯст дар баробари ғафс ва васеъшавии қабати берунии пӯст нишон медиҳад. Гарчанде ки сабаби дақиқи Lichen amyloidosis ҳанӯз пурра фаҳмида нашудааст, таҳқиқоти қаблӣ онро бо омилҳо ба монанди молиш ё сурхшавӣ дар пӯст, марги ҳуҷайраҳо, сироятҳои вирусӣ ва ғайра алоқаманд кардаанд. Lichen amyloidosis Чунин ба назар мерасад, ки бо якчанд шароити дигари пӯст алоқаманд аст (atopic dermatitis, lichen planus, mycosis fungoides) .
Lichen amyloidosis (LA) is a chronic pruritic skin disorder characterized by multiple grouped hyperkeratotic papules, predominantly located on the back, shins, thighs, and arms. Histological analysis of LA shows amyloid deposition in the papillary dermis and hyperkeratosis and acanthosis of the epidermis. The exact pathogenesis of LA has not yet been elucidated; however, prior reports have implicated frictional epidermal damage, apoptosis, viral infection, and many other triggers. LA is reportedly associated with several skin disorders, including atopic dermatitis (AD), lichen planus, and mycosis fungoides.
Lichen amyloidosis (LA) is a chronic pruritic skin disorder characterized by multiple grouped hyperkeratotic papules, predominantly located on the back, shins, thighs, and arms. Histological analysis of LA shows amyloid deposition in the papillary dermis and hyperkeratosis and acanthosis of the epidermis. The exact pathogenesis of LA has not yet been elucidated; however, prior reports have implicated frictional epidermal damage, apoptosis, viral infection, and many other triggers. LA is reportedly associated with several skin disorders, including atopic dermatitis (AD), lichen planus, and mycosis fungoides.
○ Ташхис ва табобат
#Electrophoresis of blood or urine
#Skin biopsy