Livedoid vasculitis - Васкулитҳои Livedoid
Васкулитҳои Livedoid (Livedoid vasculitis) як бемории музмӣ (хронич) пӯст аст, ки асосан дар занони ҷавони то миёнасол мушоҳида мешавад. Як мухтасар, ки барои тавсифи хусусиятҳои он истифода мешавад, «Захми пурпурии дарднок бо шакли ретикулярии узвҳои поёнӣ» (PURPLE) мебошад. Он бо як қатор бемориҳо, аз ҷумла гипертонияи венаҳои музмӣ ва варикозҳо, алоқаманд аст.
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Дар натиҷаҳои соли 2022 Stiftung Warentest аз Олмон, қаноатмандии истеъмолкунандагон аз ModelDerm нисбат ба машваратҳои пулакии телетиб танҳо каме пасттар буд.
Дар натиҷаҳои соли 2022 Stiftung Warentest аз Олмон, қаноатмандии истеъмолкунандагон аз ModelDerm нисбат ба машваратҳои пулакии телетиб танҳо каме пасттар буд.
Он метавонад бо дард ҳамроҳӣ кунад.
relevance score : -100.0%
ReferencesLivedoid vasculopathy — як ҳолати нодири пӯст аст, ки бо захмҳои дардовар, ки дар пойҳои поён бармегарданд, тавсиф мешавад.
Livedoid vasculopathy (LV) is a rare thrombotic vasculopathy of the dermis characterized by painful, relapsing ulcers over the lower extremities. Diagnosis is challenging due to the overlap in clinical appearance and nomenclature with other skin disorders. Treatment selection is complicated by poor understanding of the pathogenesis of LV and lack of robust clinical trials evaluating therapy efficacy. The terminology and pathophysiology of LV are reviewed here, along with its epidemiology, clinical and histologic features, and treatment options. A diagnostic pathway is suggested to guide providers in evaluating for comorbidities, referring to appropriate specialists, and choosing from the available classes of therapy.
Livedoid vasculopathy (LV) is a rare thrombotic vasculopathy of the dermis characterized by painful, relapsing ulcers over the lower extremities. Diagnosis is challenging due to the overlap in clinical appearance and nomenclature with other skin disorders. Treatment selection is complicated by poor understanding of the pathogenesis of LV and lack of robust clinical trials evaluating therapy efficacy. The terminology and pathophysiology of LV are reviewed here, along with its epidemiology, clinical and histologic features, and treatment options. A diagnostic pathway is suggested to guide providers in evaluating for comorbidities, referring to appropriate specialists, and choosing from the available classes of therapy.
Livedoid vasculopathy — як бемории нодири пӯст аст, ки боиси пайдоиши захмҳои такроршаванда дар пойҳои поён мегардад ва дар натиҷа захмҳои саманд, ки бо номи атрофии бланш маъруфанд, боқӣ мемонанд. Гарчанде ки сабаби дақиқ то ҳол номаълум аст, боварӣ дорад, ки афзоиши лахташавии хун (hypercoagulability) омили асосӣ ва илтиҳоб нақши дуюмдараҷа мебозад. Омилҳое, ки ба лахташавӣ мусоидат мекунанд, инҳоянд: deficiencies in proteins C and S, genetic mutations like factor V Leiden, antithrombin III deficiency, prothrombin gene mutations, high levels of homocysteine. Дар биопсия, ин ҳолат лахтаҳои хун дар дохили рагҳо, ғислшавии деворҳои рагҳо ва ҷароҳатҳоро нишон медиҳад. Табобат як равиши бисёрҷанба дар бар мегирад, ки ба пешгирии лахтаҳои хун бо доруҳо, ба монанди доруҳои зидди тромбоситҳо, лоғарҳои хун ва терапияи фибринолитикӣ тамаркуз мекунад. Барои ин ҳолати пӯст, истифодаи доруҳои гуногун мумкин аст, аз ҷумла colchicine ва hydroxychloroquine, vasodilators, immunosuppressants.
Livedoid vasculopathy is a rare skin condition that causes recurring ulcers on the lower legs, leaving behind pale scars known as atrophie blanche. While the exact cause is still unclear, it's believed that increased blood clotting (hypercoagulability) is the main factor, with inflammation playing a secondary role. Factors contributing to clotting include as follows - deficiencies in proteins C and S, genetic mutations like factor V Leiden, antithrombin III deficiency, prothrombin gene mutations, high levels of homocysteine. In biopsies, the condition shows blood clots inside vessels, thickening of vessel walls, and scarring. Treatment involves a multi-pronged approach focusing on preventing blood clots with medications like anti-platelet drugs, blood thinners, and fibrinolytic therapy. Various drugs can be used for this skin condition - colchicine and hydroxychloroquine, vasodilators, immunosuppressants.
Livedoid vasculopathy is a rare skin condition that causes recurring ulcers on the lower legs, leaving behind pale scars known as atrophie blanche. While the exact cause is still unclear, it's believed that increased blood clotting (hypercoagulability) is the main factor, with inflammation playing a secondary role. Factors contributing to clotting include as follows - deficiencies in proteins C and S, genetic mutations like factor V Leiden, antithrombin III deficiency, prothrombin gene mutations, high levels of homocysteine. In biopsies, the condition shows blood clots inside vessels, thickening of vessel walls, and scarring. Treatment involves a multi-pronged approach focusing on preventing blood clots with medications like anti-platelet drugs, blood thinners, and fibrinolytic therapy. Various drugs can be used for this skin condition - colchicine and hydroxychloroquine, vasodilators, immunosuppressants.
Livedoid vasculopathy як ҳолати нодир аст, ки дар ҳар ду по захмҳо пайдо мешавад. Ташаккули лахтаҳои хун дар рагҳои хурди хун аз сабаби зиёд шудани лахташавӣ ва коҳиши шикасти лахта дар баробари осеби пӯшиши рагҳо ба вуҷуд омадааст. Ин ҳолат бештар дар духтарон, махсусан дар синни 15 то 50 сол, маъмул аст. Даст кашидан аз тамокукашӣ, нигоҳубини захмҳо ва истифодаи доруҳо ба монанди blood thinner (лоғаркунандаи хун) ва antithrombotic drugs (дорухҳои зидди тромбоситҳо) самаранок мебошад.
Livedoid vasculopathy is a rare vasculopathy that is typically characterized by bilateral lower limb lesions. Increased thrombotic activity and decreased fibrinolytic activity along with endothelial damage are believed to be the cause of thrombus formation in the capillary vasculature. It is 3 times more common in females than in males, especially in patients between the ages of 15 to 50 years. There is no definite first-line treatment, but general measures like smoking cessation, wound care, and pharmacological measures like anticoagulants and antiplatelets have shown good results.
Livedoid vasculopathy is a rare vasculopathy that is typically characterized by bilateral lower limb lesions. Increased thrombotic activity and decreased fibrinolytic activity along with endothelial damage are believed to be the cause of thrombus formation in the capillary vasculature. It is 3 times more common in females than in males, especially in patients between the ages of 15 to 50 years. There is no definite first-line treatment, but general measures like smoking cessation, wound care, and pharmacological measures like anticoagulants and antiplatelets have shown good results.
