Porokeratosis - Порокератоз
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Дар натиҷаҳои соли 2022 Stiftung Warentest аз Олмон, қаноатмандии истеъмолкунандагон аз ModelDerm нисбат ба машваратҳои пулакии телетиб танҳо каме пасттар буд.
Дар натиҷаҳои соли 2022 Stiftung Warentest аз Олмон, қаноатмандии истеъмолкунандагон аз ModelDerm нисбат ба машваратҳои пулакии телетиб танҳо каме пасттар буд.
Кунҷҳои барҷастаи сахт характеристикӣ мебошанд.
relevance score : -100.0%
ReferencesPorokeratosis як ҳолати нодири пӯст аст, ки бо мушкилоти кератинизатсия тавсиф мешавад, ки дар натиҷа папулҳои хурд ва қаҳваранг, ҳалқашакл ё зардаҳои монанди зара пайдо мешаванд. Хусусияти муайянкунандаи он дар назди микроскоп мавҷудияти ламеллаи корноид, сохтори мушаххаси ҳуҷайраҳо дар қабати болоии пӯст мебошад. Porokeratosis дар шаклҳои гуногун меояд (disseminated superficial actinic porokeratosis, classical porokeratosis of Mibelli, porokeratosis palmaris plantaris et disseminatum, linear porokeratosis). Бояд қайд кард, ки porokeratosis метавонад ба саратони пӯст табдил ёбад. Беҳтарин роҳи ташхис porokeratosis ин тавассути биопсияи сарҳади баланд аст, гарчанде ки дар айни замон протоколи стандартии табобат вуҷуд надорад.
Porokeratosis is an uncommon dermatologic disorder. It is a disorder of keratinization that presents with keratotic papules or annular plaques with an elevated border. It has a distinct histologic hallmark of cornoid lamella, which is a column of tightly fitted parakeratotic cells in the upper epidermis. There are multiple clinical variants of porokeratosis, including disseminated superficial actinic porokeratosis, classical porokeratosis of Mibelli, porokeratosis palmaris plantaris et disseminatum, and linear porokeratosis. Porokeratosis is a precancerous lesion that can undergo malignant transformation. Evaluation of porokeratosis is best with a biopsy of the elevated border. There are no standard guidelines for treatment.
Porokeratosis is an uncommon dermatologic disorder. It is a disorder of keratinization that presents with keratotic papules or annular plaques with an elevated border. It has a distinct histologic hallmark of cornoid lamella, which is a column of tightly fitted parakeratotic cells in the upper epidermis. There are multiple clinical variants of porokeratosis, including disseminated superficial actinic porokeratosis, classical porokeratosis of Mibelli, porokeratosis palmaris plantaris et disseminatum, and linear porokeratosis. Porokeratosis is a precancerous lesion that can undergo malignant transformation. Evaluation of porokeratosis is best with a biopsy of the elevated border. There are no standard guidelines for treatment.
Disseminated superficial actinic porokeratosis (DSAP) бемории кератинизатсияи вайроншуда мебошад. Ин яке аз шаш намуди порокератоз аст ва он одатан нисбат ба дигар вариантҳои калонтар таъсир мерасонад (linear porokeratosis, porokeratosis of Mibelli, punctate porokeratosis, порокератозис палмарис эт плантарис дисизиматеда (porokeratosis palmaris et plantaris disseminata), disseminated superficial porokeratosis). Шакли эритиви порокератоз аксар вақт ба саратон, иммуносупрессия ва илтиҳоб алоқаманд аст. Омилҳои хавф аз генетика, иммуносупрессия ва таъсири нурҳои ультрафиолетӣ иборатанд. DSAP ҳамчун доғҳои гулобӣ ё қаҳваранг бо кунҷҳои баланд дар минтақаҳои офтобӣ оғоз меёбад, ки баъзан боиси хориши каме мегардад. Табобатҳо гуногунанд ва метавонанд кремҳои маҳаллӣ, терапияи рӯшноӣ ё доруҳо ба монанди 5‑фторурасил ё ретиноидҳоро дар бар гиранд. Ин захмҳо пеш аз саратон ҳисобида мешаванд ва 7.5‑10 % имкони мубаддал шудан ба карциномаҳои ҳуҷайраҳои сквамозӣ ё ҳуҷайраҳои базавӣ доранд.
Disseminated superficial actinic porokeratosis (DSAP) is a disease of disordered keratinization. Disseminated superficial actinic porokeratosis is one of six variants of porokeratosis. It has more extensive involvement than most other variants. These other variants include linear porokeratosis, porokeratosis of Mibelli, punctate porokeratosis, porokeratosis palmaris et plantaris disseminata, and disseminated superficial porokeratosis. The eruptive form of porokeratosis is associated with malignancy, immunosuppression, and a proinflammatory state. Risk factors for porokeratosis include genetics, immunosuppression, and ultraviolet light. The lesions in disseminated superficial actinic porokeratosis start as pink to brown papules and macules with a raised border in sun-exposed areas that can be asymptomatic or slightly pruritic. There are many options for the treatment of disseminated superficial actinic porokeratosis, including topical diclofenac, photodynamic therapy (PDT), 5-fluorouracil (5-FU), imiquimod, vitamin D analogs, retinoids, and lasers. These lesions are considered precancerous. There is a 7.5 to 10% risk of malignant transformation to squamous cell carcinoma or basal cell carcinoma.
Disseminated superficial actinic porokeratosis (DSAP) is a disease of disordered keratinization. Disseminated superficial actinic porokeratosis is one of six variants of porokeratosis. It has more extensive involvement than most other variants. These other variants include linear porokeratosis, porokeratosis of Mibelli, punctate porokeratosis, porokeratosis palmaris et plantaris disseminata, and disseminated superficial porokeratosis. The eruptive form of porokeratosis is associated with malignancy, immunosuppression, and a proinflammatory state. Risk factors for porokeratosis include genetics, immunosuppression, and ultraviolet light. The lesions in disseminated superficial actinic porokeratosis start as pink to brown papules and macules with a raised border in sun-exposed areas that can be asymptomatic or slightly pruritic. There are many options for the treatment of disseminated superficial actinic porokeratosis, including topical diclofenac, photodynamic therapy (PDT), 5-fluorouracil (5-FU), imiquimod, vitamin D analogs, retinoids, and lasers. These lesions are considered precancerous. There is a 7.5 to 10% risk of malignant transformation to squamous cell carcinoma or basal cell carcinoma.
Марди 52-сола, ки қаблан солим буд, бо патч атрофӣ дар қисми дилататсияи дурдасти ангушти чорум, ки 2 сол давом дошт, муаррифӣ шуд. Ин дард ҳамчун папулаи кератотик хурд оғоз ёфт ва бо гузашти вақт ба таври марказӣ калон шуд. Ӯ дар давраи табобат ба криотерапия, кортикостероидҳои топикӣ, антифунгҳо ва антибиотикҳо муроҷиат кард, вале бе таъсир монд. Тасвири дермоскопӣ нишон дод, ки марҳилаи марказӣ сухт ва атрофӣ сурх аст, бо марзи периферӣ гиперкератотик, ки ба таври тоза ҷудо шудааст. Биопсияи пӯст аз канори патч нишон дод, ки корноид ламелла бо сутуни ҳуҷайраҳои паракератотик аз инвагинацияи эпидермис, бе қабати грануларӣ, мавҷуд аст. Ин кортизонҳои клиникӣ‑патологӣ мувофиқ бо порокератозиси Мибелли (porokeratosis of Mibelli) буд.
A 52-year-old man with no past medical history presented with an asymptomatic annular atrophic patch on the distal portion of the fourth toe of 2 years’ duration. The lesion began as a small keratotic papule that gradually enlarged centrifugally. He had received multiple treatments including cryotherapy, topical corticosteroids, antifungals, and antibiotics without improvement. Dermoscopic examination revealed a scaly atrophic erythematous central area with a sharply demarcated peripheral hyperkeratotic structure. A skin biopsy of the edge of the lesion revealed a cornoid lamella with a column of parakeratotic cells extending from an invagination of the epidermis with absence of granular layer. The clinicopathologic correlation was consistent with porokeratosis of Mibelli.
A 52-year-old man with no past medical history presented with an asymptomatic annular atrophic patch on the distal portion of the fourth toe of 2 years’ duration. The lesion began as a small keratotic papule that gradually enlarged centrifugally. He had received multiple treatments including cryotherapy, topical corticosteroids, antifungals, and antibiotics without improvement. Dermoscopic examination revealed a scaly atrophic erythematous central area with a sharply demarcated peripheral hyperkeratotic structure. A skin biopsy of the edge of the lesion revealed a cornoid lamella with a column of parakeratotic cells extending from an invagination of the epidermis with absence of granular layer. The clinicopathologic correlation was consistent with porokeratosis of Mibelli.
Аксар вақт биопсия анҷом дода мешавад, зеро он метавонад ба кератози актинӣ ё карциномаҳои ҳуҷайраҳои сквамӣ монанд бошад.