Drug eruption
☆ Sa 2022 na mga resulta ng Stiftung Warentest mula sa Germany, ang kasiyahan ng consumer sa ModelDerm ay bahagyang mas mababa kaysa sa mga bayad na konsultasyon sa telemedicine.
Ang Drug eruption ay nailalarawan sa pamamagitan ng pag-apekto sa buong katawan.
relevance score : -100.0%
ReferencesAng mga reaksyon sa balat na dulot ng gamot, na kilala bilang pagputok ng droga, ay maaaring malubha kung minsan. Ang mga malubhang reaksyong ito, na tinatawag na severe cutaneous adverse drug reactions (SCARs), ay itinuturing na nagbabanta sa buhay. Kasama sa mga ito ang mga kundisyon tulad ng Stevens-Johnson syndrome (SJS), toxic epidermal necrolysis (TEN), acute generalized exanthematous pustulosis (AGEP), at drug reaction with eosinophilia and systemic symptoms (DRESS). Bagamat bihira ang SCARs, humigit-kumulang 2% ng mga pasyenteng naospital ang nakakaranas nito.
Adverse drug reactions involving the skin are commonly known as drug eruptions. Severe drug eruption may cause severe cutaneous adverse drug reactions (SCARs), which are considered to be fatal and life-threatening, including Stevens-Johnson syndrome (SJS), toxic epidermal necrolysis (TEN), acute generalized exanthematous pustulosis (AGEP), and drug reaction with eosinophilia and systemic symptoms (DRESS). Although cases are relatively rare, approximately 2% of hospitalized patients are affected by SCARs.
Adverse drug reactions involving the skin are commonly known as drug eruptions. Severe drug eruption may cause severe cutaneous adverse drug reactions (SCARs), which are considered to be fatal and life-threatening, including Stevens-Johnson syndrome (SJS), toxic epidermal necrolysis (TEN), acute generalized exanthematous pustulosis (AGEP), and drug reaction with eosinophilia and systemic symptoms (DRESS). Although cases are relatively rare, approximately 2% of hospitalized patients are affected by SCARs.
Isang 31-anyos na babae ang bumisita sa dermatology department dahil sa pulang patch sa tuktok ng kanyang kanang paa. Uminom siya ng isang dosis ng doxycycline (100 mg) noong nakaraang araw, kasunod ng picosecond laser treatment para sa acne scars. Noong nakaraang taon, naranasan niya ang katulad na problema sa parehong lugar matapos uminom ng parehong dosis ng doxycycline pagkatapos ng laser treatment. Wala siyang makabuluhang medikal na kasaysayan at wala ring iba pang mga sintomas, tulad ng lagnat, sa lokal o sa buong katawan.
A 31-year-old woman presented to the dermatology department with an asymptomatic erythematous patch on the dorsum of her right foot. She had taken 1 dose of doxycycline (100 mg) the previous day as empirical treatment after picosecond laser treatment for acne scars. She had had a similar episode the previous year on the same site, after taking the same dose of doxycycline after laser treatment. She had no notable medical history, and no other local or systemic symptoms, including fever.
A 31-year-old woman presented to the dermatology department with an asymptomatic erythematous patch on the dorsum of her right foot. She had taken 1 dose of doxycycline (100 mg) the previous day as empirical treatment after picosecond laser treatment for acne scars. She had had a similar episode the previous year on the same site, after taking the same dose of doxycycline after laser treatment. She had no notable medical history, and no other local or systemic symptoms, including fever.
Ang Stevens-Johnson syndrome (SJS) at toxic epidermal necrolysis (TEN) ay dalawang anyo ng malubhang reaksyon sa balat na naiiba sa iba pang mga kondisyon tulad ng erythema multiforme major at staphylococcal scalded skin syndrome, pati na rin sa mga reaksyon sa droga. Ang SJS/TEN ay isang bihira at malubhang reaksyon na nagdudulot ng malawak na pinsala sa balat at mucous membrane, kadalasan ay may mga systemic na sintomas. Sa mahigit 80% ng mga kaso, gamot ang sanhi.
Stevens-Johnson syndrome (SJS), and toxic epidermal necrolysis (TEN) are variants of the same condition and are distinct from erythema multiforme major staphylococcal scalded skin syndrome, and other drug eruptions. Stevens-Johnson syndrome/toxic epidermal necrolysis is a rare, acute, serious, and potentially fatal skin reaction in which there are sheet-like skin and mucosal loss accompanied by systemic symptoms. Medications are causative in over 80% of cases.
Stevens-Johnson syndrome (SJS), and toxic epidermal necrolysis (TEN) are variants of the same condition and are distinct from erythema multiforme major staphylococcal scalded skin syndrome, and other drug eruptions. Stevens-Johnson syndrome/toxic epidermal necrolysis is a rare, acute, serious, and potentially fatal skin reaction in which there are sheet-like skin and mucosal loss accompanied by systemic symptoms. Medications are causative in over 80% of cases.
Ang diagnosis ng drug eruption ay pangunahing nakabatay sa medikal na kasaysayan at klinikal na pagsusuri. Ang biopsy ng balat, mga pagsusuri sa dugo, o mga immunological test ay maaari ding makatulong.
Karaniwang mga gamot na nagdudulot ng drug eruption ay mga antibiotic at iba pang antimicrobial na gamot, sulfa drug, nonsteroidal anti-inflammatory drugs (NSAIDs), chemotherapy agents para sa malignancies, anticonvulsant, at psychotropic na gamot.
○ Diagnosis at Paggamot
Kung mayroon kang lagnat (tumaas na temperatura ng katawan), dapat kang humingi ng medikal na atensyon agad. Ang pinaghihinalaang gamot ay dapat itigil (hal. antibiotics, non‑steroidal anti‑inflammatory drugs). Bago pumunta sa ospital, ang mga oral antihistamine tulad ng cetirizine o loratadine ay maaaring makatulong sa pangangati at pantal.
#Cetirizine [Zytec]
#LevoCetirizine [Xyzal]
#Loratadine [Claritin]
Pagsusuri ng dugo (CBC, LFT, eosinophil count)
Mga oral steroid at antihistamine na may reseta ng doktor