Drug eruption
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Ang Drug eruption ay nailalarawan sa pamamagitan ng pag-apekto sa buong katawan.
References
Ang mga reaksyon sa balat na dulot ng gamot, na kilala bilang pagputok ng droga, ay maaaring malubha kung minsan. Ang mga malubhang reaksyong ito, na tinatawag na severe cutaneous adverse drug reactions (SCARs) , ay itinuturing na nagbabanta sa buhay. Kasama sa mga ito ang mga kundisyon tulad ng Stevens-Johnson syndrome (SJS) , toxic epidermal necrolysis (TEN) , acute generalized exanthematous pustulosis (AGEP) , and drug reaction with eosinophilia and systemic symptoms (DRESS) . Bagama't bihira ang SCARs , humigit-kumulang 2% ng mga pasyenteng naospital ang nakakaranas nito.
Adverse drug reactions involving the skin are commonly known as drug eruptions. Severe drug eruption may cause severe cutaneous adverse drug reactions (SCARs), which are considered to be fatal and life-threatening, including Stevens-Johnson syndrome (SJS), toxic epidermal necrolysis (TEN), acute generalized exanthematous pustulosis (AGEP), and drug reaction with eosinophilia and systemic symptoms (DRESS). Although cases are relatively rare, approximately 2% of hospitalized patients are affected by SCARs.
Adverse drug reactions involving the skin are commonly known as drug eruptions. Severe drug eruption may cause severe cutaneous adverse drug reactions (SCARs), which are considered to be fatal and life-threatening, including Stevens-Johnson syndrome (SJS), toxic epidermal necrolysis (TEN), acute generalized exanthematous pustulosis (AGEP), and drug reaction with eosinophilia and systemic symptoms (DRESS). Although cases are relatively rare, approximately 2% of hospitalized patients are affected by SCARs.
Isang 31-anyos na babae ang bumisita sa dermatology department na may walang sakit na pulang patch sa tuktok ng kanyang kanang paa. Uminom siya ng isang dosis ng doxycycline (100 mg) noong nakaraang araw, kasunod ng picosecond laser treatment para sa acne scars. Noong nakaraang taon, nakaranas siya ng katulad na isyu sa parehong lugar pagkatapos kumuha ng parehong dosis ng doxycycline post-laser treatment. Wala siyang makabuluhang medikal na kasaysayan at walang iba pang mga sintomas, tulad ng lagnat, sa lokal o sa buong katawan niya.
A 31-year-old woman presented to the dermatology department with an asymptomatic erythematous patch on the dorsum of her right foot. She had taken 1 dose of doxycycline (100 mg) the previous day as empirical treatment after picosecond laser treatment for acne scars. She had had a similar episode the previous year on the same site, after taking the same dose of doxycycline after laser treatment. She had no notable medical history, and no other local or systemic symptoms, including fever.
A 31-year-old woman presented to the dermatology department with an asymptomatic erythematous patch on the dorsum of her right foot. She had taken 1 dose of doxycycline (100 mg) the previous day as empirical treatment after picosecond laser treatment for acne scars. She had had a similar episode the previous year on the same site, after taking the same dose of doxycycline after laser treatment. She had no notable medical history, and no other local or systemic symptoms, including fever.
Ang Stevens-Johnson syndrome (SJS) at toxic epidermal necrolysis (TEN) ay dalawang anyo ng malubhang reaksyon sa balat, naiiba sa iba pang mga kondisyon ng balat tulad ng erythema multiforme major at staphylococcal scalded skin syndrome, pati na rin ang mga reaksyon sa droga. Ang SJS/TEN ay isang bihira at malubhang reaksyon na nagdudulot ng malawakang pinsala sa balat at mucous membrane, kadalasang may mga systemic na sintomas. Sa mahigit 80% ng mga kaso, gamot ang dahilan.
Stevens-Johnson syndrome (SJS), and toxic epidermal necrolysis (TEN) are variants of the same condition and are distinct from erythema multiforme major staphylococcal scalded skin syndrome, and other drug eruptions. Stevens-Johnson syndrome/toxic epidermal necrolysis is a rare, acute, serious, and potentially fatal skin reaction in which there are sheet-like skin and mucosal loss accompanied by systemic symptoms. Medications are causative in over 80% of cases.
Stevens-Johnson syndrome (SJS), and toxic epidermal necrolysis (TEN) are variants of the same condition and are distinct from erythema multiforme major staphylococcal scalded skin syndrome, and other drug eruptions. Stevens-Johnson syndrome/toxic epidermal necrolysis is a rare, acute, serious, and potentially fatal skin reaction in which there are sheet-like skin and mucosal loss accompanied by systemic symptoms. Medications are causative in over 80% of cases.
Ang mga pagsabog ng droga ay pangunahing nasuri mula sa medikal na kasaysayan at klinikal na pagsusuri. Ang isang biopsy sa balat, mga pagsusuri sa dugo o mga pagsusuri sa immunological ay maaari ding maging kapaki-pakinabang.
Ang mga halimbawa ng mga karaniwang gamot na nagdudulot ng pagsabog ay mga antibiotic at iba pang antimicrobial na gamot, sulfa na gamot, nonsteroidal anti-inflammatory drugs (NSAIDs), chemotherapy agent para sa malignancies, anticonvulsant at psychotropic na gamot.
○ Diagnosis at Paggamot
Kung mayroon kang lagnat (tumaas na temperatura ng katawan), dapat kang humingi ng medikal na atensyon sa lalong madaling panahon. Ang pinaghihinalaang gamot ay dapat na ihinto (hal. antibiotics, non-steroidal anti-inflammatory drugs). Bago bumisita sa ospital, ang mga oral antihistamine tulad ng cetirizine o loratadine ay maaaring makatulong para sa pangangati at pantal.
#Cetirizine [Zytec]
#LevoCetirizine [Xyzal]
#Loratadine [Claritin]
Pagsusuri ng dugo (CBC, LFT, eosinophil count)
Mga oral steroid at antihistamine na may reseta ng doktor