Intraepithelial carcinoma (Bowen disease) - Intraepithelial Carcinoma (Sakit Sa Bowen)
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Karaniwang kaso ― Intraepithelial Carcinoma (Sakit Sa Bowen) (Intraepithelial carcinoma (Bowen disease)) ay maaaring ma-misdiagnose bilang isang pangmatagalan, hindi makati na eksema.
References
Ang Bowen's disease (BD) ay isang uri ng kanser sa balat na nagsisimula sa panlabas na layer ng balat (epidermis) . Ito ay mas karaniwan sa mga Caucasians at madalas na nangyayari sa mga lugar na nakalantad sa sikat ng araw, ngunit maaari rin itong lumitaw sa ibang lugar. Karaniwang lumalabas ang BD bilang isang solong sugat. Ang BD ay madalas na nakikita bilang isang senyales ng babala bago magkaroon ng mas malubhang uri ng kanser sa balat. Upang masuri ang BD, karaniwang umaasa ang mga doktor sa pagsusuri ng mga sample ng tissue sa ilalim ng mikroskopyo (biopsy) .
Bowen's disease (BD) is an in-situ squamous cell carcinoma of epidermis. The etiology of BD is multifactorial with high incidence among Caucasians. BD is common in photo-exposed areas of skin, but other sites can also be involved. Lesions are usually solitary. The morphology of BD differs based on age of the lesion, site of origin, and the degree of keratinization. BD is considered as the lull before the storm, which precedes an overt squamous cell carcinoma. Histopathology is the gold standard diagnostic modality to confirm the diagnosis.
Bowen's disease (BD) is an in-situ squamous cell carcinoma of epidermis. The etiology of BD is multifactorial with high incidence among Caucasians. BD is common in photo-exposed areas of skin, but other sites can also be involved. Lesions are usually solitary. The morphology of BD differs based on age of the lesion, site of origin, and the degree of keratinization. BD is considered as the lull before the storm, which precedes an overt squamous cell carcinoma. Histopathology is the gold standard diagnostic modality to confirm the diagnosis.
Bowen's disease kadalasang nakakaapekto sa mga puting indibidwal na may edad na higit sa 60. Kabilang sa mga pangunahing salik sa panganib ang pangmatagalang pagkakalantad sa araw, humina ang immune system, pagkakalantad sa arsenic, at impeksyon sa HPV sa balat. Ang mga strain ng HPV 16, 18, 34, at 48 ay nauugnay sa sakit na Bowen sa mga bahagi ng ari. Hindi gaanong malinaw ang pagkakasangkot ng HPV sa mga non-genital cases.
Bowen disease is most commonly found in white patients over 60 years old. Other risk factors include chronic sun exposure, immunosuppression, arsenic exposure and cutaneous human papillomavirus (HPV) infection. HPV types 16, 18, 34 and 48 cause Bowen disease at genital sites; the role of HPV in nongenital cases of Bowen disease is less well defined. HPV types 2, 16, 34 and 35 have been rarely identified within nongenital lesions.
Bowen disease is most commonly found in white patients over 60 years old. Other risk factors include chronic sun exposure, immunosuppression, arsenic exposure and cutaneous human papillomavirus (HPV) infection. HPV types 16, 18, 34 and 48 cause Bowen disease at genital sites; the role of HPV in nongenital cases of Bowen disease is less well defined. HPV types 2, 16, 34 and 35 have been rarely identified within nongenital lesions.
Karaniwan itong lumilitaw bilang isang erythematous, scaly o crusty na lugar kahit saan sa katawan. Ang pinakakaraniwang lokasyon ay mas mababang mga binti.
Ito ay nalulunasan ng iba't ibang opsyon sa paggamot gaya ng cryotherapy, curettage, cautery, photodynamic therapy, o excision ng lesyon.
○ Diagnosis at Paggamot
#Dermoscopy
#Skin biopsy
#Mohs surgery
#Photodynamic therapy