Keratoacanthoma
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Karaniwang Keratoacanthoma
References
Ang Keratoacanthoma (KA) ay isang madalas na tumor sa balat na kilala sa mabilis na paglaki nito at potensyal na mag-regress nang mag-isa. Karaniwang nangyayari ito sa mas matanda, maputi ang balat na mga lalaki na may kasaysayan ng pinsala sa araw. Habang ang surgical removal gamit ang excision o Mohs micrographic surgery ay ang karaniwang paggamot, mayroong iba't ibang opsyon sa therapy na magagamit.
Keratoacanthoma (KA) is a common cutaneous tumor characterized by rapid growth and possible spontaneous regression. It most commonly affects older, fair-skinned males with significantly sun damaged skin. Although surgical removal with excision or Mohs micrographic surgery remains the standard of therapy, there are many alternative therapeutic modalities that can be utilized.
Keratoacanthoma (KA) is a common cutaneous tumor characterized by rapid growth and possible spontaneous regression. It most commonly affects older, fair-skinned males with significantly sun damaged skin. Although surgical removal with excision or Mohs micrographic surgery remains the standard of therapy, there are many alternative therapeutic modalities that can be utilized.
Ang Keratoacanthoma (KA) ay isang mababang uri ng tumor na nagsisimula sa ilang mga glandula sa balat at mukhang katulad ng squamous cell carcinoma (SCC) sa ilalim ng mikroskopyo. Mayroong patuloy na debate tungkol sa kung dapat bang uriin ang KA bilang isang anyo ng invasive na SCC.
Keratoacanthoma (KA) is a comparatively common low-grade tumor that initiates in the pilo-sebaceous glands and pathologically mimics squamous cell carcinoma (SCC). Essentially, strong debates confirm classifying keratoacanthoma as a variant of invasive SCC. The clinical behavior of KA is hardly predictable and the differential diagnosis of keratoacanthoma and other conditions with keratoacanthoma-like pseudocarcinomatous epithelial hyperplasia is challenging, both clinically and histopathologically.
Keratoacanthoma (KA) is a comparatively common low-grade tumor that initiates in the pilo-sebaceous glands and pathologically mimics squamous cell carcinoma (SCC). Essentially, strong debates confirm classifying keratoacanthoma as a variant of invasive SCC. The clinical behavior of KA is hardly predictable and the differential diagnosis of keratoacanthoma and other conditions with keratoacanthoma-like pseudocarcinomatous epithelial hyperplasia is challenging, both clinically and histopathologically.
Ang Cutaneous squamous cell carcinoma (cSCC) ay ang pangalawang pinakakaraniwang uri ng kanser sa mga tao, lalo na sa mga matatandang indibidwal. Karaniwang ginagamit ang operasyon upang gamutin ang cSCC, ngunit para sa ilang mga pasyente na hindi maaaring magpaopera o pumili ng hindi, maaaring isaalang-alang ang iba pang mga opsyon tulad ng mga intralesional na paggamot. Ginamit ang mga tradisyunal na intralesional na paggamot (methotrexate or 5-fluorouracil) , ngunit may patuloy na pananaliksik sa mga bagong diskarte tulad ng intralesional immunotherapy at oncolytic virotherapy. Dito, titingnan natin ang iba't ibang intralesional na paggamot para sa cSCC, mula sa mga klasikong pamamaraan hanggang sa mga makabagong diskarte.
Cutaneous squamous cell carcinoma (cSCC) is the second most frequent cancer in humans, and it is especially common in fragile, elderly people. Surgery is the standard treatment for cSCC but intralesional treatments can be an alternative in those patients who are either not candidates or refuse to undergo surgery. Classic intralesional treatments, including methotrexate or 5-fluorouracil, have been implemented, but there is now a landscape of active research to incorporate intralesional immunotherapy and oncolytic virotherapy into the scene, which might change the way we deal with cSCC in the future. In this review, we focus on intralesional treatments for cSCC (including keratoacanthoma), from classic to very novel strategies.
Cutaneous squamous cell carcinoma (cSCC) is the second most frequent cancer in humans, and it is especially common in fragile, elderly people. Surgery is the standard treatment for cSCC but intralesional treatments can be an alternative in those patients who are either not candidates or refuse to undergo surgery. Classic intralesional treatments, including methotrexate or 5-fluorouracil, have been implemented, but there is now a landscape of active research to incorporate intralesional immunotherapy and oncolytic virotherapy into the scene, which might change the way we deal with cSCC in the future. In this review, we focus on intralesional treatments for cSCC (including keratoacanthoma), from classic to very novel strategies.
Sa ilalim ng mikroskopyo, ang keratoacanthoma ay napakalapit na kahawig ng squamous cell carcinoma. Habang inuuri ng ilang pathologist ang keratoacanthoma bilang isang natatanging entity at hindi isang malignancy, humigit-kumulang 6% ng clinical at histological keratoacanthoma ang umuunlad sa invasive at agresibong squamous cell cancers.
○ Diagnosis at Paggamot
#Dermoscopy
#Skin biopsy