Livedoid vasculitis
Ang Livedoid vasculitis ay isang talamak na sakit sa balat na kadalasang nakikita sa kabataan hanggang sa nasa katanghaliang-gulang na mga kababaihan. Ang isang acronym na ginamit upang ilarawan ang mga tampok nito ay "Masakit na purpuric ulcers na may reticular pattern ng lower extremities" (PURPLE). Ito ay nauugnay sa isang bilang ng mga sakit, kabilang ang talamak na venous hypertension at varicosities.
☆ Sa 2022 na mga resulta ng Stiftung Warentest mula sa Germany, ang kasiyahan ng consumer sa ModelDerm ay bahagyang mas mababa kaysa sa mga bayad na konsultasyon sa telemedicine.
Ito ay maaaring sinamahan ng sakit.
References
Ang Livedoid vasculopathy ay isang bihirang kondisyon ng balat na nailalarawan ng mga masakit na ulser na patuloy na bumabalik sa ibabang mga binti.
Livedoid vasculopathy (LV) is a rare thrombotic vasculopathy of the dermis characterized by painful, relapsing ulcers over the lower extremities. Diagnosis is challenging due to the overlap in clinical appearance and nomenclature with other skin disorders. Treatment selection is complicated by poor understanding of the pathogenesis of LV and lack of robust clinical trials evaluating therapy efficacy. The terminology and pathophysiology of LV are reviewed here, along with its epidemiology, clinical and histologic features, and treatment options. A diagnostic pathway is suggested to guide providers in evaluating for comorbidities, referring to appropriate specialists, and choosing from the available classes of therapy.
Livedoid vasculopathy (LV) is a rare thrombotic vasculopathy of the dermis characterized by painful, relapsing ulcers over the lower extremities. Diagnosis is challenging due to the overlap in clinical appearance and nomenclature with other skin disorders. Treatment selection is complicated by poor understanding of the pathogenesis of LV and lack of robust clinical trials evaluating therapy efficacy. The terminology and pathophysiology of LV are reviewed here, along with its epidemiology, clinical and histologic features, and treatment options. A diagnostic pathway is suggested to guide providers in evaluating for comorbidities, referring to appropriate specialists, and choosing from the available classes of therapy.
Ang Livedoid vasculopathy ay isang bihirang kondisyon ng balat na nagdudulot ng mga paulit-ulit na ulser sa ibabang binti, na nag-iiwan ng maputlang peklat na kilala bilang atrophie blanche. Bagama't hindi pa malinaw ang eksaktong dahilan, pinaniniwalaan na ang pagtaas ng pamumuo ng dugo (hypercoagulability) ang pangunahing salik, na may pangalawang papel na ginagampanan ng pamamaga. Ang mga salik na nag-aambag sa pamumuo ay kinabibilangan ng mga sumusunod - deficiencies in proteins C and S, genetic mutations like factor V Leiden, antithrombin III deficiency, prothrombin gene mutations, high levels of homocysteine. Sa mga biopsy, ang kondisyon ay nagpapakita ng mga namuong dugo sa loob ng mga sisidlan, pampalapot ng mga pader ng sisidlan, at pagkakapilat. Ang paggamot ay nagsasangkot ng isang multi-pronged na diskarte na nakatuon sa pagpigil sa mga pamumuo ng dugo gamit ang mga gamot tulad ng mga anti-platelet na gamot, pampalabnaw ng dugo, at fibrinolytic therapy. Maaaring gamitin ang iba't ibang gamot para sa kondisyon ng balat na ito - colchicine and hydroxychloroquine, vasodilators, immunosuppressants.
Livedoid vasculopathy is a rare skin condition that causes recurring ulcers on the lower legs, leaving behind pale scars known as atrophie blanche. While the exact cause is still unclear, it's believed that increased blood clotting (hypercoagulability) is the main factor, with inflammation playing a secondary role. Factors contributing to clotting include as follows - deficiencies in proteins C and S, genetic mutations like factor V Leiden, antithrombin III deficiency, prothrombin gene mutations, high levels of homocysteine. In biopsies, the condition shows blood clots inside vessels, thickening of vessel walls, and scarring. Treatment involves a multi-pronged approach focusing on preventing blood clots with medications like anti-platelet drugs, blood thinners, and fibrinolytic therapy. Various drugs can be used for this skin condition - colchicine and hydroxychloroquine, vasodilators, immunosuppressants.
Livedoid vasculopathy is a rare skin condition that causes recurring ulcers on the lower legs, leaving behind pale scars known as atrophie blanche. While the exact cause is still unclear, it's believed that increased blood clotting (hypercoagulability) is the main factor, with inflammation playing a secondary role. Factors contributing to clotting include as follows - deficiencies in proteins C and S, genetic mutations like factor V Leiden, antithrombin III deficiency, prothrombin gene mutations, high levels of homocysteine. In biopsies, the condition shows blood clots inside vessels, thickening of vessel walls, and scarring. Treatment involves a multi-pronged approach focusing on preventing blood clots with medications like anti-platelet drugs, blood thinners, and fibrinolytic therapy. Various drugs can be used for this skin condition - colchicine and hydroxychloroquine, vasodilators, immunosuppressants.
Ang Livedoid vasculopathy ay isang bihirang kondisyon kung saan ang mga sugat ay nangyayari sa magkabilang binti. Ang pagbuo ng mga namuong dugo sa maliliit na daluyan ng dugo ay pinaniniwalaang sanhi ng pagtaas ng pamumuo at pagbawas ng pagkasira ng namuong dugo, kasama ng pinsala sa lining ng daluyan. Ito ay mas karaniwan sa mga babae, lalo na sa pagitan ng edad na 15 at 50. Ang pagtigil sa paninigarilyo, pag-aalaga ng mga sugat, at paggamit ng mga gamot tulad ng mga blood thinner at antiplatelet na gamot ay naging epektibo.
Livedoid vasculopathy is a rare vasculopathy that is typically characterized by bilateral lower limb lesions. Increased thrombotic activity and decreased fibrinolytic activity along with endothelial damage are believed to be the cause of thrombus formation in the capillary vasculature. It is 3 times more common in females than in males, especially in patients between the ages of 15 to 50 years. There is no definite first-line treatment, but general measures like smoking cessation, wound care, and pharmacological measures like anticoagulants and antiplatelets have shown good results.
Livedoid vasculopathy is a rare vasculopathy that is typically characterized by bilateral lower limb lesions. Increased thrombotic activity and decreased fibrinolytic activity along with endothelial damage are believed to be the cause of thrombus formation in the capillary vasculature. It is 3 times more common in females than in males, especially in patients between the ages of 15 to 50 years. There is no definite first-line treatment, but general measures like smoking cessation, wound care, and pharmacological measures like anticoagulants and antiplatelets have shown good results.
