Lymphangioma
Ang Lymphangioma ay mga malformations ng lymphatic system na nailalarawan sa pamamagitan ng mga sugat na manipis na pader na mga cyst. Ang mga malformation na ito ay maaaring mangyari sa anumang edad at maaaring may kinalaman sa anumang bahagi ng katawan, ngunit 90% ay nangyayari sa mga batang wala pang 2 taong gulang at kinasasangkutan ng ulo at leeg. Ang mga lymphangiomas ay karaniwang sinusuri bago ipanganak gamit ang fetal ultrasonography. Ang mga nakuhang lymphangiomas ay maaaring magresulta mula sa trauma, pamamaga, o lymphatic obstruction. Dahil wala silang pagkakataon na maging malignant, ang mga lymphangiomas ay kadalasang ginagamot para sa mga kadahilanang kosmetiko lamang.
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References
Ang Lymphangioma ay kilala rin bilang lymphatic malformation (LM) . Ito ay isang vascular disorder na naroroon mula sa kapanganakan. Ito ay nailalarawan sa pamamagitan ng abnormal na paglaki ng lymphatic tissue bago at pagkatapos ng kapanganakan. Ang Lymphangioma ay nakakaapekto sa humigit-kumulang 1 sa 2000 hanggang 4000 na tao, na walang makabuluhang pagkakaiba sa pagitan ng mga kasarian o lahi. Karamihan sa mga kaso (80–90%) ay nasuri bago ang edad na dalawa. Ang mga sintomas ay malawak na nag-iiba, mula sa naisalokal na pamamaga hanggang sa malawak na abnormalidad sa mga lymphatic channel, kung minsan ay humahantong sa matinding pamamaga na kilala bilang elephantiasis. Halimbawa, ang lymphangioma sa leeg at mukha ay maaaring magdulot ng pamamaga ng mukha, at sa malalang kaso, pagkasira ng anyo. Kapag naapektuhan nito ang dila, maaari itong humantong sa paglaki ng panga at hindi pagkakapantay-pantay ng mga ngipin. Sa bibig at leeg, maaari itong magdulot ng mga problema sa paghinga at mga emergency na nagbabanta sa buhay. Sa mga mata, maaari itong maging sanhi ng pagkawala ng paningin, limitadong paggalaw ng mata, paglaylay ng talukap ng mata, at pag-umbok ng mga mata. Ang pagkakasangkot sa paa ay maaaring magdulot ng pamamaga at abnormal na paglaki ng mga tisyu at buto. Karaniwang dahan-dahang lumalaki ang tumor na ito, ngunit ang mga impeksyon, pagbabago sa hormonal, o pinsala ay maaaring magdulot ng mabilis na paglaki, na naghahatid ng mga panganib na nagbabanta sa buhay na nangangailangan ng agarang paggamot.
Lymphangioma (lymphatic malformation, LM), a congenital vascular disease, is a low-flow vascular abnormality in lymphatic diseases that is characterized by excessive growth of lymphatic tissue during prenatal and postpartum development. The incidence rate of LM is ~1:2000–4000, with no variation between genders and races. Most patients (80–90%) are diagnosed before the age of two. The clinical manifestations of lymphangioma are quite different among patients, varying from local swelling leading to superficial mass to a large area of diffuse infiltrating lymphatic channel abnormalities resulting in elephantiasis. Cervicofacial LM can cause facial elephantiasis, and in some severe cases, it can lead to serious disfigurement of the face. Tongue LM can lead to mandibular overgrowth and occlusal asymmetry, and oral and cervical LM can cause obstructive acute respiratory distress and life-threatening situations. Orbital LM may lead to decreased vision, decreased extraocular muscle movement, ptosis and exophthalmos. LM of the extremities can trigger swelling or gigantism, accompanied by overgrowth of soft tissue and bones. LM usually grows slowly and steadily, but under certain conditions, such as infection, hormonal changes or trauma, it can grow explosively and become a life-threatening disease requiring immediate treatment.
Lymphangioma (lymphatic malformation, LM), a congenital vascular disease, is a low-flow vascular abnormality in lymphatic diseases that is characterized by excessive growth of lymphatic tissue during prenatal and postpartum development. The incidence rate of LM is ~1:2000–4000, with no variation between genders and races. Most patients (80–90%) are diagnosed before the age of two. The clinical manifestations of lymphangioma are quite different among patients, varying from local swelling leading to superficial mass to a large area of diffuse infiltrating lymphatic channel abnormalities resulting in elephantiasis. Cervicofacial LM can cause facial elephantiasis, and in some severe cases, it can lead to serious disfigurement of the face. Tongue LM can lead to mandibular overgrowth and occlusal asymmetry, and oral and cervical LM can cause obstructive acute respiratory distress and life-threatening situations. Orbital LM may lead to decreased vision, decreased extraocular muscle movement, ptosis and exophthalmos. LM of the extremities can trigger swelling or gigantism, accompanied by overgrowth of soft tissue and bones. LM usually grows slowly and steadily, but under certain conditions, such as infection, hormonal changes or trauma, it can grow explosively and become a life-threatening disease requiring immediate treatment.
Sa retrospective na pag-aaral na ito, sinuri namin ang 24 na bata na nagkaroon ng lymphangioma at nagamot sa pamamagitan ng mga iniksyon ng bleomycin solution mula Enero 1999 hanggang Disyembre 2004. Karamihan sa mga sugat (63%) ay ganap na nawala, 21% ang nakakuha ng magandang tugon, at 16% hindi nakasagot ng maayos. Dalawang pasyente ang bumalik pagkatapos ng tumor, at dalawang iba pa ang nagkaroon ng abscesses kung saan sila nagpa-iniksyon. Sa kabutihang palad, wala kaming nakitang iba pang malalaking problema o epekto.
This is a retrospective study of 24 children diagnosed with lymphangioma and treated with intralesional injection of bleomycin aqueous solution from January 1999 to December 2004. Complete resolution was seen in 63% (15/24) of lesions, 21% (5/24) had good response and 16% (4/24) had poor response. The tumour recurred in 2 patients. Two other patients had abscess formation at the site of injection. No other serious complications or side effects were observed.
This is a retrospective study of 24 children diagnosed with lymphangioma and treated with intralesional injection of bleomycin aqueous solution from January 1999 to December 2004. Complete resolution was seen in 63% (15/24) of lesions, 21% (5/24) had good response and 16% (4/24) had poor response. The tumour recurred in 2 patients. Two other patients had abscess formation at the site of injection. No other serious complications or side effects were observed.
Ang mga pangunahing uri ng lymphangioma ay ang mga sumusunod - lymphangioma circumscriptum, cavernous lymphangioma, cystic hygroma, lymphangioendothelioma. Ang mga ito ay bumubuo sa humigit-kumulang 26% ng mga benign vascular tumor sa mga bata ngunit hindi gaanong karaniwan sa mga matatanda. Ang lymphangioma circumscriptum , ang pinakamadalas na uri, ay nagpapakita ng mga lymphatic duct na nakausli sa balat, na bumubuo ng malinaw na mga vesicle na puno ng likido na katulad ng frog spawn, kasama ng tissue swelling. Karaniwan itong lumilitaw sa mga lugar na may masaganang lymphatic network tulad ng mga limbs, trunk, at armpits. Isang 71-taong-gulang na babae ang pumunta sa aming klinika na may patuloy na pamamaga ng binti, kulay-rosas na bukol sa kanyang ari, pangangati, at pagtagas ng lymph fluid. Inalis namin ang lahat ng bukol sa pamamagitan ng operasyon na tinatawag na bilateral major labiectomy, huminto sa antas ng fascia ni Colles, habang pinapanatili ang klitoris at fourchette.
The predominant types of lymphangioma are lymphangioma circumscriptum (LC), cavernous lymphangioma, cystic hygroma, and lymphangioendothelioma. These entities account for approximately 26% of benign vascular tumors in children but are rarer in adults. LC is the most common form of cutaneous lymphangioma and is characterized by superficial lymphatic ducts protruding through the epidermis. This condition results in clusters of clear fluid-filled vesicles resembling frog spawn and associated tissue edema. It is usually found on the proximal extremity, trunk, and axilla, which has an abundant lymphatic system. A 71-year-old female presented to our outpatient clinic with persistent edema of both lower limbs, clusters of pink labial papules, pruritus, and watery lymph oozing. We removed all the papules by performing bilateral major labiectomy down to the level of Colles' fascia, sparing the clitoris and fourchette.
The predominant types of lymphangioma are lymphangioma circumscriptum (LC), cavernous lymphangioma, cystic hygroma, and lymphangioendothelioma. These entities account for approximately 26% of benign vascular tumors in children but are rarer in adults. LC is the most common form of cutaneous lymphangioma and is characterized by superficial lymphatic ducts protruding through the epidermis. This condition results in clusters of clear fluid-filled vesicles resembling frog spawn and associated tissue edema. It is usually found on the proximal extremity, trunk, and axilla, which has an abundant lymphatic system. A 71-year-old female presented to our outpatient clinic with persistent edema of both lower limbs, clusters of pink labial papules, pruritus, and watery lymph oozing. We removed all the papules by performing bilateral major labiectomy down to the level of Colles' fascia, sparing the clitoris and fourchette.
