Panniculitis
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References
Erythema nodosum is the most common form of panniculitis and is characterized by tender erythematous nodules mainly in the lower limbs on the pretibial area. The exact cause of erythema nodosum is unknown, although it appears to be a hypersensitivity response to a variety of antigenic stimuli. Although the etiology is mostly idiopathic, ruling out an underlying disease is imperative before diagnosing primary erythema nodosum. Erythema nodosum can be the first sign of a systemic disease that is triggered by a large group of processes, such as infections, inflammatory diseases, neoplasia, and/or drugs. The most common identifiable causes are streptococcal infections, primary tuberculosis, sarcoidosis, Behçet disease, inflammatory bowel disease, drugs, and pregnancy.
Panniculitis bumuo ng isang heterogenous na grupo ng mga nagpapaalab na sakit na kinasasangkutan ng subcutaneous adipose tissue. Ang mga karamdaman na ito ay bihira sa mga bata. Ang panniculitis ay maaaring ang pangunahing proseso sa isang systemic disorder o isang pangalawang proseso na nagreresulta mula sa impeksyon, trauma o pagkakalantad sa gamot. Karamihan sa mga uri ng panniculitis ay may parehong klinikal na presentasyon (anuman ang etiology) , na may malambot, erythematous subcutaneous nodules.
Panniculitides form a heterogenous group of inflammatory diseases that involve the subcutaneous adipose tissue. These disorders are rare in children and have many aetiologies. As in adults, the panniculitis can be the primary process in a systemic disorder or a secondary process that results from infection, trauma or exposure to medication. Some types of panniculitis are seen more commonly or exclusively in children, and several new entities have been described in recent years. Most types of panniculitis have the same clinical presentation (regardless of the aetiology), with tender, erythematous subcutaneous nodules.
Panniculitides form a heterogenous group of inflammatory diseases that involve the subcutaneous adipose tissue. These disorders are rare in children and have many aetiologies. As in adults, the panniculitis can be the primary process in a systemic disorder or a secondary process that results from infection, trauma or exposure to medication. Some types of panniculitis are seen more commonly or exclusively in children, and several new entities have been described in recent years. Most types of panniculitis have the same clinical presentation (regardless of the aetiology), with tender, erythematous subcutaneous nodules.
Panniculitis , pamamaga ng subcutaneous fat, kadalasang nagpapakita ng mga inflammatory nodules. Ang Erythema nodosum (EN) ay ang klinikal na pinakamadalas na anyo ng panniculitis. Habang hanggang sa 55% ng EN ay itinuturing na idiopathic, ang mga pinakakaraniwang sanhi ay kinabibilangan ng mga impeksyon, droga, mga sistemang sakit gaya ng sarcoidosis at inflammatory bowel disease, pagbubuntis, at malignancy. Karaniwang makikita ang EN sa mga kabataan at 20s, at mas madalas na nakikita sa mga babae. Madalas itong nauuna ng isang hindi partikular na prodrome ng isa hanggang tatlong linggo, na maaaring may kasamang lagnat, karamdaman, at mga sintomas ng impeksyon sa upper respiratory tract. Pagkatapos ay kasunod ang mga sugat sa balat, karaniwang naka-localize sa extensor na aspeto ng mga limbs. Ang mga sugat ay masakit na bilugan o hugis-itlog, bahagyang nakataas, di-ulcerative na pulang nodules. Ang eksaktong pathogenesis ng EN ay hindi nauunawaan, bagama't pinaniniwalaang nagreresulta mula sa pagtitiwalag ng mga immune complex sa mga venules ng septae sa subcutaneous fat, na nagdudulot ng neutrophilic panniculitis. Kahit na walang partikular na therapy para sa isang sanhi ng kondisyon, ang EN ay lumulutas nang walang paggamot sa karamihan ng mga kaso.
Panniculitis, inflammation of the subcutaneous fat, usually presents with inflammatory nodules. Erythema nodosum (EN) is clinically the most frequent form of panniculitis. Whilst up to 55% of EN is considered idiopathic, the most common causes include infections, drugs, systemic illnesses such as sarcoidosis and inflammatory bowel disease, pregnancy, and malignancy. EN typically presents in the teens and 20s, and is seen more commonly in females. It is often preceded by a non-specific prodrome of one to three weeks, which may include fever, malaise, and symptoms of an upper respiratory tract infection. Cutaneous lesions then follow, typically localized on the extensor aspect of the limbs. The lesions are painful rounded or oval, slightly raised, non-ulcerative red nodules. The exact pathogenesis of EN is not understood, although is thought to result from deposition of immune complexes in the venules of the septae in subcutaneous fat, causing a neutrophilic panniculitis. Even without specific therapy for a causative condition, EN resolves without treatment in most cases.
Panniculitis, inflammation of the subcutaneous fat, usually presents with inflammatory nodules. Erythema nodosum (EN) is clinically the most frequent form of panniculitis. Whilst up to 55% of EN is considered idiopathic, the most common causes include infections, drugs, systemic illnesses such as sarcoidosis and inflammatory bowel disease, pregnancy, and malignancy. EN typically presents in the teens and 20s, and is seen more commonly in females. It is often preceded by a non-specific prodrome of one to three weeks, which may include fever, malaise, and symptoms of an upper respiratory tract infection. Cutaneous lesions then follow, typically localized on the extensor aspect of the limbs. The lesions are painful rounded or oval, slightly raised, non-ulcerative red nodules. The exact pathogenesis of EN is not understood, although is thought to result from deposition of immune complexes in the venules of the septae in subcutaneous fat, causing a neutrophilic panniculitis. Even without specific therapy for a causative condition, EN resolves without treatment in most cases.
Ang "Erythema nodosum" ay isang anyo ng panniculitis na nailalarawan ng malalambot na pulang nodule, 1–10 cm, na nauugnay sa mga systemic na sintomas kabilang ang lagnat, karamdaman, at pananakit ng kasukasuan. Maaaring humupa ang mga bukol sa loob ng 2-6 na linggo nang walang ulcer o pagkakapilat. Ang Erythema nodosum ay nauugnay sa mga impeksyon, kabilang ang Hepatitis C, EBV at tuberculosis, pagbubuntis, Non-Hodgkin lymphoma, at pancreatic cancer.