Karagdagang informasiyon ― Filipino

Ang Squamous cell carcinoma (SCC) ay ang pangalawang pinakakaraniwang kanser sa balat sa United States, pagkatapos ng basal cell carcinoma. Karaniwan itong nagsisimula sa mga precancerous na lesyon na tinatawag na actinic keratosis , at maaaring kumalat sa ibang bahagi ng katawan. Ang pangunahing dahilan ay ang pagkakalantad sa ultraviolet (UV) radiation mula sa araw, na naiipon sa paglipas ng panahon. Karaniwang kinasasangkutan ng paggamot ang pag-aalis ng kirurhiko, lalo na para sa SCC sa ulo at leeg. Ang radiation therapy ay isang opsyon para sa mga matatandang pasyente o sa mga hindi maaaring operahan. Ang immunosuppression ay nagpapataas ng panganib ng SCC. Bagama't bihira, maaaring kumalat ang SCC, lalo na sa mga pasyenteng may mahinang immune system. Ang regular na check-up at proteksyon sa araw ay mahalaga para sa mga may SCC.
Squamous cell carcinoma of the skin or cutaneous squamous cell carcinoma is the second most common form of skin cancer in the United States, behind basal cell carcinoma. Squamous cell carcinoma has precursor lesions called actinic keratosis, exhibits tumor progression and has the potential to metastasize in the body. Ultraviolet (UV) solar radiation is the primary risk factor in the development of cutaneous squamous cell carcinoma and the cumulative exposure received over a lifetime plays a major part in the development of this cancer. Surgical excision is the primary treatment modality for cutaneous squamous cell carcinoma, with Mohs micrographic surgery being the preferred excisional technique for squamous cell carcinoma of the head and neck, and in other areas of high risk or squamous cell carcinoma with high-risk characteristics. Radiation therapy is reserved for squamous cell carcinoma in older patients or those who will not tolerate surgery, or when it has not been possible to obtain clear margins surgically. Adjuvant radiotherapy is commonly after surgical treatment in very high tumors. Immunosuppression significantly increases the risk of squamous cell carcinoma over the course of an individual’s life. Metastasis is uncommon for squamous cell carcinomas arising in areas of chronic sun exposure, but it can take place, and the risk is increased in immunosuppressed patients. Patients with cutaneous squamous cell carcinoma should be examined regularly and remember to use measures to protect from UV damage.

Ang Cutaneous squamous cell carcinoma (CSCC) ay ang pangalawa sa pinakakaraniwang cancer sa mga tao, at tumataas ang bilang nito. Bagama't ang CSCC ay karaniwang nagpapakita ng hindi magandang klinikal na pag-uugali, maaari itong kumalat sa parehong lokal at sa iba pang bahagi ng katawan. Natukoy ng mga siyentipiko ang mga partikular na landas na kasangkot sa pagbuo ng CSCC, na humahantong sa mga bagong paggamot. Ang mataas na bilang ng mga mutasyon at mas mataas na panganib sa mga pasyenteng immunosuppressed ay nag-udyok sa pagbuo ng immunotherapy. Tinitingnan ng pagsusuring ito ang mga genetic na ugat ng CSCC at ang pinakabagong mga paggamot na nagta-target sa mga partikular na molekula at immune system.
Cutaneous squamous cell carcinoma (CSCC) is the second most frequent cancer in humans and its incidence continues to rise. Although CSCC usually display a benign clinical behavior, it can be both locally invasive and metastatic. The signaling pathways involved in CSCC development have given rise to targetable molecules in recent decades. In addition, the high mutational burden and increased risk of CSCC in patients under immunosuppression were part of the rationale for developing the immunotherapy for CSCC that has changed the therapeutic landscape. This review focuses on the molecular basis of CSCC and the current biology-based approaches of targeted therapies and immune checkpoint inhibitors