Keratoacanthoma - Keratoakantom
☆ Almanya'daki 2022 Stiftung Warentest sonuçlarında ModelDerm'den tüketici memnuniyeti, ücretli teletıp danışmanlıklarından yalnızca biraz daha düşüktü.
Tipik Keratoakantom (Keratoacanthoma)
References
Keratoacanthoma (KA) hızlı büyümesi ve kendi kendine gerileme potansiyeli ile bilinen, sık görülen bir cilt tümörüdür. Genellikle güneş hasarı öyküsü olan, yaşlı, açık tenli erkeklerde görülür. Eksizyon veya Mohs mikrografik cerrahi kullanılarak cerrahi olarak çıkarılması olağan tedavi olsa da, başka çeşitli tedavi seçenekleri de mevcuttur.
Keratoacanthoma (KA) is a common cutaneous tumor characterized by rapid growth and possible spontaneous regression. It most commonly affects older, fair-skinned males with significantly sun damaged skin. Although surgical removal with excision or Mohs micrographic surgery remains the standard of therapy, there are many alternative therapeutic modalities that can be utilized.
Keratoacanthoma (KA) is a common cutaneous tumor characterized by rapid growth and possible spontaneous regression. It most commonly affects older, fair-skinned males with significantly sun damaged skin. Although surgical removal with excision or Mohs micrographic surgery remains the standard of therapy, there are many alternative therapeutic modalities that can be utilized.
Keratoacanthoma (KA) , derideki belirli bezlerde başlayan ve mikroskop altında squamous cell carcinoma (SCC) 'ya benzeyen düşük dereceli bir tümördür. KA'nın invaziv SCC'nin bir formu olarak sınıflandırılması gerekip gerekmediği konusunda devam eden bir tartışma var.
Keratoacanthoma (KA) is a comparatively common low-grade tumor that initiates in the pilo-sebaceous glands and pathologically mimics squamous cell carcinoma (SCC). Essentially, strong debates confirm classifying keratoacanthoma as a variant of invasive SCC. The clinical behavior of KA is hardly predictable and the differential diagnosis of keratoacanthoma and other conditions with keratoacanthoma-like pseudocarcinomatous epithelial hyperplasia is challenging, both clinically and histopathologically.
Keratoacanthoma (KA) is a comparatively common low-grade tumor that initiates in the pilo-sebaceous glands and pathologically mimics squamous cell carcinoma (SCC). Essentially, strong debates confirm classifying keratoacanthoma as a variant of invasive SCC. The clinical behavior of KA is hardly predictable and the differential diagnosis of keratoacanthoma and other conditions with keratoacanthoma-like pseudocarcinomatous epithelial hyperplasia is challenging, both clinically and histopathologically.
Cutaneous squamous cell carcinoma (cSCC) insanlarda, özellikle yaşlı bireylerde en sık görülen ikinci kanser türüdür. Cerrahi genellikle cSCC'yi tedavi etmek için kullanılır, ancak ameliyat olamayan veya yapmamayı seçen bazı hastalar için intralezyonel tedaviler gibi diğer seçenekler düşünülebilir. Geleneksel lezyon içi tedaviler (methotrexate or 5-fluorouracil) kullanılmıştır, ancak lezyon içi immünoterapi ve onkolitik viroterapi gibi yeni yaklaşımlar üzerinde devam eden araştırmalar vardır. Burada klasik yöntemlerden en ileri stratejilere kadar cSCC'ye yönelik farklı lezyon içi tedavilere bakacağız.
Cutaneous squamous cell carcinoma (cSCC) is the second most frequent cancer in humans, and it is especially common in fragile, elderly people. Surgery is the standard treatment for cSCC but intralesional treatments can be an alternative in those patients who are either not candidates or refuse to undergo surgery. Classic intralesional treatments, including methotrexate or 5-fluorouracil, have been implemented, but there is now a landscape of active research to incorporate intralesional immunotherapy and oncolytic virotherapy into the scene, which might change the way we deal with cSCC in the future. In this review, we focus on intralesional treatments for cSCC (including keratoacanthoma), from classic to very novel strategies.
Cutaneous squamous cell carcinoma (cSCC) is the second most frequent cancer in humans, and it is especially common in fragile, elderly people. Surgery is the standard treatment for cSCC but intralesional treatments can be an alternative in those patients who are either not candidates or refuse to undergo surgery. Classic intralesional treatments, including methotrexate or 5-fluorouracil, have been implemented, but there is now a landscape of active research to incorporate intralesional immunotherapy and oncolytic virotherapy into the scene, which might change the way we deal with cSCC in the future. In this review, we focus on intralesional treatments for cSCC (including keratoacanthoma), from classic to very novel strategies.
Mikroskop altında keratoakantom (keratoacanthoma) skuamöz hücreli karsinoma çok benzer. Bazı patologlar keratoakantom (keratoacanthoma) 'u malignite değil ayrı bir antite olarak sınıflandırırken, klinik ve histolojik keratoakantom (keratoacanthoma) 'ların yaklaşık %6'sı invaziv ve agresif skuamöz hücreli kanserlere doğru ilerlemektedir.
○ Teşhis ve tedavi
#Dermoscopy
#Skin biopsy