Livedoid vasculitis - Livedoid Vaskülit
Livedoid Vaskülit (Livedoid vasculitis) ağırlıklı olarak genç ve orta yaşlı kadınlarda görülen kronik bir kutanöz hastalıktır. Özelliklerini tanımlamak için kullanılan kısaltmalardan biri "Alt ekstremitelerde retiküler desenli ağrılı purpurik ülserler"dir (MOR). Kronik venöz hipertansiyon ve varisler de dahil olmak üzere bir dizi hastalıkla ilişkilidir.
☆ Almanya'daki 2022 Stiftung Warentest sonuçlarında ModelDerm'den tüketici memnuniyeti, ücretli teletıp danışmanlıklarından yalnızca biraz daha düşüktü.
Ağrı eşlik edebilir.
References
Livedoid vasculopathy , alt bacaklarda sürekli tekrarlayan ağrılı ülserlerle karakterize nadir bir cilt rahatsızlığıdır.
Livedoid vasculopathy (LV) is a rare thrombotic vasculopathy of the dermis characterized by painful, relapsing ulcers over the lower extremities. Diagnosis is challenging due to the overlap in clinical appearance and nomenclature with other skin disorders. Treatment selection is complicated by poor understanding of the pathogenesis of LV and lack of robust clinical trials evaluating therapy efficacy. The terminology and pathophysiology of LV are reviewed here, along with its epidemiology, clinical and histologic features, and treatment options. A diagnostic pathway is suggested to guide providers in evaluating for comorbidities, referring to appropriate specialists, and choosing from the available classes of therapy.
Livedoid vasculopathy (LV) is a rare thrombotic vasculopathy of the dermis characterized by painful, relapsing ulcers over the lower extremities. Diagnosis is challenging due to the overlap in clinical appearance and nomenclature with other skin disorders. Treatment selection is complicated by poor understanding of the pathogenesis of LV and lack of robust clinical trials evaluating therapy efficacy. The terminology and pathophysiology of LV are reviewed here, along with its epidemiology, clinical and histologic features, and treatment options. A diagnostic pathway is suggested to guide providers in evaluating for comorbidities, referring to appropriate specialists, and choosing from the available classes of therapy.
Livedoid vasculopathy , alt bacaklarda tekrarlayan ülserlere neden olan ve arkasında atrofi beyazlığı olarak bilinen soluk yara izleri bırakan nadir bir cilt rahatsızlığıdır. Kesin neden hala belirsiz olsa da artan kan pıhtılaşmasının (hypercoagulability) ana faktör olduğuna, iltihaplanmanın ise ikincil bir rol oynadığına inanılıyor. Pıhtılaşmaya katkıda bulunan faktörler arasında aşağıdakiler yer alır - deficiencies in proteins C and S, genetic mutations like factor V Leiden, antithrombin III deficiency, prothrombin gene mutations, high levels of homocysteine. Biyopsilerde bu durum damarların içindeki kan pıhtılarını, damar duvarlarının kalınlaşmasını ve yara izini gösterir. Tedavi, anti-trombosit ilaçlar, kan inceltici ilaçlar ve fibrinolitik tedavi gibi ilaçlarla kan pıhtılarını önlemeye odaklanan çok yönlü bir yaklaşımı içerir. Bu cilt rahatsızlığı için çeşitli ilaçlar kullanılabilir - colchicine and hydroxychloroquine, vasodilators, immunosuppressants.
Livedoid vasculopathy is a rare skin condition that causes recurring ulcers on the lower legs, leaving behind pale scars known as atrophie blanche. While the exact cause is still unclear, it's believed that increased blood clotting (hypercoagulability) is the main factor, with inflammation playing a secondary role. Factors contributing to clotting include as follows - deficiencies in proteins C and S, genetic mutations like factor V Leiden, antithrombin III deficiency, prothrombin gene mutations, high levels of homocysteine. In biopsies, the condition shows blood clots inside vessels, thickening of vessel walls, and scarring. Treatment involves a multi-pronged approach focusing on preventing blood clots with medications like anti-platelet drugs, blood thinners, and fibrinolytic therapy. Various drugs can be used for this skin condition - colchicine and hydroxychloroquine, vasodilators, immunosuppressants.
Livedoid vasculopathy is a rare skin condition that causes recurring ulcers on the lower legs, leaving behind pale scars known as atrophie blanche. While the exact cause is still unclear, it's believed that increased blood clotting (hypercoagulability) is the main factor, with inflammation playing a secondary role. Factors contributing to clotting include as follows - deficiencies in proteins C and S, genetic mutations like factor V Leiden, antithrombin III deficiency, prothrombin gene mutations, high levels of homocysteine. In biopsies, the condition shows blood clots inside vessels, thickening of vessel walls, and scarring. Treatment involves a multi-pronged approach focusing on preventing blood clots with medications like anti-platelet drugs, blood thinners, and fibrinolytic therapy. Various drugs can be used for this skin condition - colchicine and hydroxychloroquine, vasodilators, immunosuppressants.
Livedoid vasculopathy her iki bacakta da lezyonların meydana geldiği nadir bir durumdur. Küçük kan damarlarında kan pıhtılarının oluşmasının, pıhtılaşmanın artması ve pıhtı parçalanmasının azalmasının yanı sıra damar astarındaki hasardan kaynaklandığı düşünülmektedir. Kadınlarda, özellikle 15-50 yaş arası daha sık görülür. Sigarayı bırakmak, yaralara bakım yapmak, kan sulandırıcı ve antitrombosit ilaçlar gibi ilaçlar kullanmak etkili olmuştur.
Livedoid vasculopathy is a rare vasculopathy that is typically characterized by bilateral lower limb lesions. Increased thrombotic activity and decreased fibrinolytic activity along with endothelial damage are believed to be the cause of thrombus formation in the capillary vasculature. It is 3 times more common in females than in males, especially in patients between the ages of 15 to 50 years. There is no definite first-line treatment, but general measures like smoking cessation, wound care, and pharmacological measures like anticoagulants and antiplatelets have shown good results.
Livedoid vasculopathy is a rare vasculopathy that is typically characterized by bilateral lower limb lesions. Increased thrombotic activity and decreased fibrinolytic activity along with endothelial damage are believed to be the cause of thrombus formation in the capillary vasculature. It is 3 times more common in females than in males, especially in patients between the ages of 15 to 50 years. There is no definite first-line treatment, but general measures like smoking cessation, wound care, and pharmacological measures like anticoagulants and antiplatelets have shown good results.
