Amyloidosis - Amiloidoz
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Klassik yuz xususiyatlari Amiloidoz (Amyloidosis)
References
26 yoshli ayol poliklinikamizga oyoqlarida 10 yildan beri davom etayotgan qichima toshmasi shikoyati bilan keldi. Ukol kremlari va tazaroten kremlaridan foydalanishga qaramay, toshma yaxshilanmadi. Uning tegishli oilaviy tarixi yo'q edi. Biz uni tekshirganimizda, biz uning oyoqlari old qismida lichen amyloidosis deb nomlangan kasallikka mos keladigan ko'tarilgan, qo'pol yamoqlarni topdik.
A 26-year-old woman presented to our clinic with an itchy rash on her legs that had persisted for 10 years. The rash had previously been treated with topical steroids and tazarotene cream, with no improvement. The patient’s family history was noncontributory. A physical examination showed discrete and coalescing hyperkeratotic tan-brown papules on the pretibial surfaces, consistent with lichen amyloidosis.
A 26-year-old woman presented to our clinic with an itchy rash on her legs that had persisted for 10 years. The rash had previously been treated with topical steroids and tazarotene cream, with no improvement. The patient’s family history was noncontributory. A physical examination showed discrete and coalescing hyperkeratotic tan-brown papules on the pretibial surfaces, consistent with lichen amyloidosis.
Lichen Amyloidosis - noma'lum sabablarga ko'ra doimiy qichishish bilan bog'liq bo'lgan noyob teri kasalligi. Odatda terining tashqi yuzalarida ko'tarilgan, rangi o'zgargan dog'lar to'plami sifatida namoyon bo'ladi. Lichen Amyloidosis odatda 50 dan 60 yoshgacha bo'lgan odamlarda paydo bo'ladi va afsuski, uni davolab bo'lmaydi. Hozir mavjud muolajalar odatda yaxshi natija bermaydi.
Lichen Amyloidosis (LA) is an uncommon, primary cutaneous amyloidosis associated with chronic, idiopathic pruritus. Clinical presentation of LA includes skin colored to hyperpigmented, papules coalescing into plaques with a rippled appearance on the extensors.1 LA most commonly presents in the fifth to sixth decade of life and has no curative treatments. Overall response to current therapies is poor.
Lichen Amyloidosis (LA) is an uncommon, primary cutaneous amyloidosis associated with chronic, idiopathic pruritus. Clinical presentation of LA includes skin colored to hyperpigmented, papules coalescing into plaques with a rippled appearance on the extensors.1 LA most commonly presents in the fifth to sixth decade of life and has no curative treatments. Overall response to current therapies is poor.
Lichen amyloidosis - terining uzoq davom etadigan qichishi. U asosan orqa, boldirlar, sonlar va qo'llarda joylashgan qalinlashgan bo'rtma to'plamlari bilan mashhur. Mikroskop ostida tekshirilganda, Lichen amyloidosis terining yuqori qatlamida amiloid to'planishi va tashqi teri qatlamining qalinlashishi va kattalashishini ko'rsatadi. Lichen amyloidosis ning aniq sababi hali to'liq tushunilmagan bo'lsa-da, oldingi tadqiqotlar buni teriga ishqalanish yoki ishqalanish, hujayralar o'limi, virusli infektsiyalar va boshqalar bilan bog'lagan. Lichen amyloidosis atopic dermatitis, lichen planus, and mycosis fungoides kabi bir qancha boshqa teri kasalliklari bilan bog'langanga o'xshaydi.
Lichen amyloidosis (LA) is a chronic pruritic skin disorder characterized by multiple grouped hyperkeratotic papules, predominantly located on the back, shins, thighs, and arms. Histological analysis of LA shows amyloid deposition in the papillary dermis and hyperkeratosis and acanthosis of the epidermis. The exact pathogenesis of LA has not yet been elucidated; however, prior reports have implicated frictional epidermal damage, apoptosis, viral infection, and many other triggers. LA is reportedly associated with several skin disorders, including atopic dermatitis (AD), lichen planus, and mycosis fungoides.
Lichen amyloidosis (LA) is a chronic pruritic skin disorder characterized by multiple grouped hyperkeratotic papules, predominantly located on the back, shins, thighs, and arms. Histological analysis of LA shows amyloid deposition in the papillary dermis and hyperkeratosis and acanthosis of the epidermis. The exact pathogenesis of LA has not yet been elucidated; however, prior reports have implicated frictional epidermal damage, apoptosis, viral infection, and many other triggers. LA is reportedly associated with several skin disorders, including atopic dermatitis (AD), lichen planus, and mycosis fungoides.
○ Diagnoz va davolash
#Electrophoresis of blood or urine
#Skin biopsy