Drug eruption
☆ Germaniyaning 2022 yilgi Stiftung Warentest natijalariga ko'ra, iste'molchilarning ModelDermdan qoniqish darajasi pullik teletibbiyot maslahatlariga qaraganda bir oz pastroq bo'lgan.
Drug eruption butun organizmga ta'sir qilish bilan tavsiflanadi.
References
Dori-darmonlardan kelib chiqqan teri reaktsiyalari, ba'zida dori portlashi deb nomlanuvchi, ba'zida og'ir bo'lishi mumkin. Severe cutaneous adverse drug reactions (SCARs) deb nomlangan ushbu og'ir reaktsiyalar hayot uchun xavfli hisoblanadi. Ularga Stevens-Johnson syndrome (SJS) , toxic epidermal necrolysis (TEN) , acute generalized exanthematous pustulosis (AGEP) , and drug reaction with eosinophilia and systemic symptoms (DRESS) kabi shartlar kiradi. SCARs kamdan-kam hollarda bo'lsa-da, kasalxonaga yotqizilgan bemorlarning taxminan 2 foizi ularni boshdan kechiradi.
Adverse drug reactions involving the skin are commonly known as drug eruptions. Severe drug eruption may cause severe cutaneous adverse drug reactions (SCARs), which are considered to be fatal and life-threatening, including Stevens-Johnson syndrome (SJS), toxic epidermal necrolysis (TEN), acute generalized exanthematous pustulosis (AGEP), and drug reaction with eosinophilia and systemic symptoms (DRESS). Although cases are relatively rare, approximately 2% of hospitalized patients are affected by SCARs.
Adverse drug reactions involving the skin are commonly known as drug eruptions. Severe drug eruption may cause severe cutaneous adverse drug reactions (SCARs), which are considered to be fatal and life-threatening, including Stevens-Johnson syndrome (SJS), toxic epidermal necrolysis (TEN), acute generalized exanthematous pustulosis (AGEP), and drug reaction with eosinophilia and systemic symptoms (DRESS). Although cases are relatively rare, approximately 2% of hospitalized patients are affected by SCARs.
31 yoshli ayol dermatologiya bo'limiga o'ng oyog'i tepasida og'riqsiz qizil dog' bilan murojaat qildi. U akne izlari uchun pikosoniyali lazer bilan davolashdan so'ng bir kun oldin bir doza doksisiklin (100 mg) oldi. O'tgan yili u lazerdan keyin bir xil dozada doksisiklinni qabul qilganidan keyin xuddi shu joyda xuddi shunday muammoga duch keldi. Uning jiddiy kasallik tarixi va mahalliy yoki butun tanasida isitma kabi boshqa alomatlari yo'q.
A 31-year-old woman presented to the dermatology department with an asymptomatic erythematous patch on the dorsum of her right foot. She had taken 1 dose of doxycycline (100 mg) the previous day as empirical treatment after picosecond laser treatment for acne scars. She had had a similar episode the previous year on the same site, after taking the same dose of doxycycline after laser treatment. She had no notable medical history, and no other local or systemic symptoms, including fever.
A 31-year-old woman presented to the dermatology department with an asymptomatic erythematous patch on the dorsum of her right foot. She had taken 1 dose of doxycycline (100 mg) the previous day as empirical treatment after picosecond laser treatment for acne scars. She had had a similar episode the previous year on the same site, after taking the same dose of doxycycline after laser treatment. She had no notable medical history, and no other local or systemic symptoms, including fever.
Stevens-Johnson syndrome (SJS) va toxic epidermal necrolysis (TEN) jiddiy teri reaktsiyasining ikkita shakli bo'lib, ular ko'p shaklli eritema va stafilokokk kuygan teri sindromi kabi boshqa teri kasalliklaridan, shuningdek, dori reaktsiyalaridan farq qiladi. SJS/TEN kamdan-kam uchraydigan va og'ir reaktsiya bo'lib, teri va shilliq pardalarning keng tarqalgan shikastlanishiga olib keladi, ko'pincha tizimli alomatlar bilan. 80% hollarda dori-darmonlar sabab bo'ladi.
Stevens-Johnson syndrome (SJS), and toxic epidermal necrolysis (TEN) are variants of the same condition and are distinct from erythema multiforme major staphylococcal scalded skin syndrome, and other drug eruptions. Stevens-Johnson syndrome/toxic epidermal necrolysis is a rare, acute, serious, and potentially fatal skin reaction in which there are sheet-like skin and mucosal loss accompanied by systemic symptoms. Medications are causative in over 80% of cases.
Stevens-Johnson syndrome (SJS), and toxic epidermal necrolysis (TEN) are variants of the same condition and are distinct from erythema multiforme major staphylococcal scalded skin syndrome, and other drug eruptions. Stevens-Johnson syndrome/toxic epidermal necrolysis is a rare, acute, serious, and potentially fatal skin reaction in which there are sheet-like skin and mucosal loss accompanied by systemic symptoms. Medications are causative in over 80% of cases.
Giyohvand moddalarning portlashi asosan kasallik tarixi va klinik tekshiruvdan aniqlanadi. Teri biopsiyasi, qon testlari yoki immunologik testlar ham foydali bo'lishi mumkin.
Antibiotiklar va boshqa mikroblarga qarshi dorilar, sulfa preparatlari, steroid bo'lmagan yallig'lanishga qarshi dorilar (NSAID), malign o'smalarni davolash uchun kimyoterapiya vositalari, antikonvulsanlar va psixotrop dorilar portlashiga olib keladigan keng tarqalgan dori-darmonlarga misol bo'la oladi.
○ Diagnoz va davolash
Agar sizda isitma (tana haroratining ko'tarilishi) bo'lsa, iloji boricha tezroq tibbiy yordamga murojaat qilishingiz kerak. Shubhali preparatni qabul qilishni to'xtatish kerak (masalan, antibiotiklar, steroid bo'lmagan yallig'lanishga qarshi dorilar). Kasalxonaga borishdan oldin, setirizin yoki loratadin kabi og'iz antigistaminlari qichishish va toshmalarga yordam berishi mumkin.
#Cetirizine [Zytec]
#LevoCetirizine [Xyzal]
#Loratadine [Claritin]
Qon testi (CBC, LFT, eozinofillar soni)
Shifokorning retsepti bilan og'iz orqali steroidlar va antigistaminlar