Onychomysosis - Tirnoqlari Qo'Ziqorini
☆ Germaniyaning 2022 yilgi Stiftung Warentest natijalariga ko'ra, iste'molchilarning ModelDermdan qoniqish darajasi pullik teletibbiyot maslahatlariga qaraganda bir oz pastroq bo'lgan.
Tirnoqlari Qo'Ziqorini (Onychomysosis) ta'sirlangan oyoq tirnoq
Terbinafin og'iz dori kursiga o'n hafta qo'ziqorin tirnoq infektsiyasi bilan bir kishining oyog'i. Qolgan infektsiyalangan tirnoqlarning orqasida sog'lom tirnoq o'sishi bandiga e'tibor bering.
References
Tizimli antifungallar eng samarali davolash hisoblanadi. Meta-tahlillar mikotik davolash tezligini quyidagicha ko'rsatadi: terbinafine = 76%, itraconazole with pulse dosing = 63%, itraconazole with continuous dosing = 59%, fluconazole =48% . Tirnoqlarni bir vaqtda tozalash davolash tezligini yanada oshiradi. Ciclopirox bilan topikal terapiya unchalik samarali emas; 60% dan ortiq muvaffaqiyatsizlik darajasiga ega.
Systemic antifungals are the most effective treatment. Meta-analyses shows mycotic cure rates as follows: terbinafine = 76%, itraconazole with pulse dosing = 63%, itraconazole with continuous dosing = 59%, fluconazole =48%. Concomitant nail debridement further increases cure rates. Topical therapy with ciclopirox is less effective; it has a failure rate exceeding 60%.
Systemic antifungals are the most effective treatment. Meta-analyses shows mycotic cure rates as follows: terbinafine = 76%, itraconazole with pulse dosing = 63%, itraconazole with continuous dosing = 59%, fluconazole =48%. Concomitant nail debridement further increases cure rates. Topical therapy with ciclopirox is less effective; it has a failure rate exceeding 60%.
Onikomikoz - bu tirnoqlarga ta'sir qiladigan qo'ziqorin infektsiyasi. Agar dermatofitlar sabab bo'lsa, u tinea unguium deb ataladi. Onikomikozga dermatofitlar, xamirturushlar va mog'or keltirib chiqaradigan infektsiyalar kiradi. Qo'ziqorin infektsiyasidan kelib chiqmagan tirnoq muammosi nail dystrophy deb ataladi. Qo'l va oyoq tirnoqlariga ham ta'sir qilishi mumkin bo'lsa-da, oyoq tirnoqlarining onikomikozi ko'proq uchraydi. Ushbu maqolada oyoq tirnoqlari onikomikozining turli jihatlari, masalan, uning ta'siri, klinik turlari, bosqichlari, tashxisi va davolash usullari muhokama qilinadi. Onikomikoz hayot uchun xavfli bo'lmasa-da, selülit, sepsis, suyak infektsiyasi, to'qimalarning shikastlanishi va tirnoqlarning yo'qolishi kabi jiddiy asoratlarga olib kelishi mumkin.
Onychomycosis is a fungal infection of the nail unit. When dermatophytes cause onychomycosis, this condition is called tinea unguium. The term onychomycosis encompasses the dermatophytes, yeasts, and saprophytic mold infections. An abnormal nail not caused by a fungal infection is a dystrophic nail. Onychomycosis can infect both fingernails and toenails, but onychomycosis of the toenail is much more prevalent. Discussed in detail in this activity are all evolving facets of the topic, including disease burden, clinical types, staging, diagnosis, and management of toenail onychomycosis. While non-life-threatening, onychomycosis can lead to severe complications such as cellulitis, sepsis, osteomyelitis, tissue damage, and nail loss.
Onychomycosis is a fungal infection of the nail unit. When dermatophytes cause onychomycosis, this condition is called tinea unguium. The term onychomycosis encompasses the dermatophytes, yeasts, and saprophytic mold infections. An abnormal nail not caused by a fungal infection is a dystrophic nail. Onychomycosis can infect both fingernails and toenails, but onychomycosis of the toenail is much more prevalent. Discussed in detail in this activity are all evolving facets of the topic, including disease burden, clinical types, staging, diagnosis, and management of toenail onychomycosis. While non-life-threatening, onychomycosis can lead to severe complications such as cellulitis, sepsis, osteomyelitis, tissue damage, and nail loss.
Terbinafine - skualen epoksidazani blokirovka qilish orqali qo'ziqorin infektsiyalariga qarshi kurashadigan dori. Bu teri qo'ziqorinlarining ko'p turlariga qarshi samarali va og'iz orqali qabul qilinganda tirnoq qo'ziqorinlarini davolash uchun tasdiqlangan. Bosh og'rig'i va oshqozon bilan bog'liq muammolar kabi ko'plab nojo'ya ta'sirlar kichik bo'lib, o'z-o'zidan yo'qolsa-da, ta'mdagi o'zgarishlar (disgeuziya) engildan og'irgacha o'zgarishi mumkin, ba'zan esa vazn yo'qotishiga olib keladi. Doimiy ta'm o'zgarishi kamdan-kam uchraydi, ammo ular haqida xabar berilgan.
Terbinafine is an antifungal medication that works through the inhibition of squalene epoxidase. It has activity against most dermatophytes, and it has approval for use as an oral therapy for the treatment of onychomycosis. Although most side effects are mild and self-limited, such as headache and gastrointestinal symptoms, taste disturbances (dysgeusia) can range from mild to severe, resulting in weight loss, and have rarely been reported permanent.
Terbinafine is an antifungal medication that works through the inhibition of squalene epoxidase. It has activity against most dermatophytes, and it has approval for use as an oral therapy for the treatment of onychomycosis. Although most side effects are mild and self-limited, such as headache and gastrointestinal symptoms, taste disturbances (dysgeusia) can range from mild to severe, resulting in weight loss, and have rarely been reported permanent.
Onikomikoz - tirnoqlarga ta'sir qiladigan qo'ziqorin infektsiyasi. Oyoq tirnoqlari infektsiyalarining taxminan 90% va tirnoq infektsiyalarining 75% zamburug'lardan kelib chiqadi (Trichophyton mentagrophytes, Trichophyton rubrum) . Alomatlar orasida tirnoq rangi o'zgarishi, qalinlashishi, tirnoq to'shagidan ajralishi va ortiqcha o'sishi kiradi. Davolash odatda terbinafin yoki itrakonazol kabi og'iz orqali yuboriladigan dori-darmonlarni o'z ichiga oladi, topikal davolash engil va o'rtacha og'irlikdagi holatlar uchun tanlovdir.
Onychomycosis is a fungal infection of the nail unit. Approximately 90% of toenail and 75% of fingernail onychomycosis are caused by dermatophytes, notably Trichophyton mentagrophytes and Trichophyton rubrum. Clinical manifestations include discoloration of the nail, subungual hyperkeratosis, onycholysis, and onychauxis. Currently, oral terbinafine is the treatment of choice, followed by oral itraconazole. In general, topical monotherapy can be considered for mild to moderate onychomycosis.
Onychomycosis is a fungal infection of the nail unit. Approximately 90% of toenail and 75% of fingernail onychomycosis are caused by dermatophytes, notably Trichophyton mentagrophytes and Trichophyton rubrum. Clinical manifestations include discoloration of the nail, subungual hyperkeratosis, onycholysis, and onychauxis. Currently, oral terbinafine is the treatment of choice, followed by oral itraconazole. In general, topical monotherapy can be considered for mild to moderate onychomycosis.
Og'iz orqali qabul qilingan antifungal dori terbinafin eng samarali bo'lib ko'rinadi, ammo terbinafin jigarning yon ta'siri bilan bog'liq.
tirnoqlari qo'ziqorini (onychomysosis) kattalar aholisining taxminan 10 foizida uchraydi, keksa odamlar ko'proq ta'sir qiladi. Erkaklar ayollarga qaraganda tez-tez ta'sirlanadi. tirnoqlari qo'ziqorini (onychomysosis) tirnoq kasalligining yarmini bildiradi. Bu shuni anglatadiki, oyoq tirnoqlarining deformatsiyasi onikomikozdan tashqari boshqa sabablarga ham olib kelishi mumkin.
○ Davolash ― OTC dorilar
Onikomikozni mahalliy dorilar bilan davolash qiyin, chunki dorilar qalinlashgan oyoq tirnoqlariga kirib borishi qiyin.
#Ketoconazole
#Clotrimazole
#Miconazole
#Terbinafine
#Butenafine [Lotrimin]
#Tolnaftate
○ Davolash
Infektsiyalangan tirnoq butunlay olib tashlanmaguncha uzoq muddatli davolanish odatda talab qilinadi.
#Terbinafine (oral)
#Itraconazole
#Efinaconazole lacquer [Jublia]
#Ciclopirox lacquer